ВЛИЯНИЕ ЗАКАЛИВАЮЩИХ ПРОЦЕДУР НА ИММУНОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ И ПОКАЗАТЕЛИ БЕЛОЙ КРОВИ ДЕТЕЙ 4–6 ЛЕТ
Ключевые слова:
закаливание, иммуноглобулины, цитокины, лейкоциты, дети дошкольного возраста
Аннотация
Цель: изучить влияние программы закаливания на иммунологические и лейкоцитарные показатели у дошкольников 4–6 лет в условиях дошкольного образовательного учреждения. Материалы и методы. Исследование проводилось на группе из 81 ребенка дошкольного возраста, разделенных на три экспериментальные группы: группу закаливания (n = 53), группу контраста (n = 12) и контрольную группу (n = 16). Группа закаливания подвергалась систематическим закаливающим процедурам пять раз в неделю по разработанной схеме контрастных температурных воздействий. Группа контраста участвовала в программе закаливания с дополнительными сеансами в сауне. Контрольная группа придерживалась стандартного режима дошкольного учреждения без применения специальных закаливающих мероприятий. Результаты. Закаливающие процедуры не оказывают существенного влияния на содержание иммуноглобулинов и показатели белой крови, но вызывают незначительные изменения содержания цитокинов в крови детей групп закаливания и контраста по сравнению с контрольной группой. Наличие положительной корреляции между содержанием ФНО-α и нейтрофилами в группах контроля и закаливания может указывать на базовую готовность организма к быстрому иммунному ответу. Напротив, в случае отрицательной корреляции между этими показателями в крови детей группы контраста – на изменение реакции иммунной системы под влиянием теплового воздействия. Об этом также свидетельствует наличие положительной корреляции между содержанием ФНО-α и моноцитами в крови детей группы контраста. Заключение. Отсутствие значимых изменений в количестве лейкоцитов и иммуноглобулинов, а также выявленные изменения в уровнях цитокинов, не выходящие за пределы референтных значений у детей групп закаливания и контраста, могут указывать на то, что иммунная система адекватно реагирует на стимулы, связанные с закаливающими процедурами, не переходя в состояние патологической активации.
Литература
1. Гейн, С.В. Влияние холодового стресса на функциональную активность перитонеальных макрофагов в условиях блокады опиатных рецепторов / С.В. Гейн, И.Л. Шаравьева // Мед. иммунология. – 2017. – Т. 19. – С. 21–22.
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3. Фишер, Т.А. Методология закаливания в дошкольном образовательном учреждении / Т.А. Фишер, Е.Л. Дремина, С.С. Бобрешова. – Новосибирск: СО РАН, 2022. – 100 с.
4. Чернова, Е.Д. Значение закаливания для здоровья человека / Е.Д. Чернова // E-SCIO. – 2021. – С. 6–13.
5. A Review on Physiological Changes Associated with Cold Water Exposure / S.Selvasekar, M.Priya, S. Lakshmi, S.Muralidharan // International Journal of Creative Research Thoughts. – 2021. – Vol. 9 (8). – P. 45–53.
6. Banfi, G. Whole-body cryotherapy in athletes / G. Banfi, G. Lombardi, A. Colombini // Sports Medicine. – 2012. – Vol. 40. – P. 509–517. DOI: 10.2165/11531940-0000000000-00000
7. Cytokine-induced Neutrophil-derived I nterleukin-8 / R.M. Strieter, K. Kasahara, R.M. Allen et al. // American Journal of Pathology. – 1992. – Vol. 141 (2). – P. 397–407.
8. Diehl, S. The two faces of IL-6 on Th1/Th2 differentiation / S. Diehl, M. Ricon // Molecular Immunology. – 2002. – Vol. 39 (9). – P. 531–536. DOI: 10.1016/S0161-5890(02)00210-9
9. Dugue, B. Adaptation related to cytokines in man: Effects of regular swimming in ice-cold water / B. Dugue, E. Leppänen // Clinical Physiology. – 2000. – No. 20 (2). – P. 114–121. DOI: 10.1046/j.1365-2281.2000.00235.x
10. Immune system of cold-exposed and cold-adapted humans / L. Jansky, D. Pospilova, S. Honzova et al. // European journal of applied physiology and occupational physiology. – 1996. – No. 72 (5-6). – P. 445–450. DOI: 10.1007/BF00242274
11. Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach / M. Aliyu, F. Zohora, A.U. Anka et al. // International Immunopharmacology. – 2022. – Vol. 111. – P. 109–130. DOI: 10.1016/j.intimp.2022.109130
12. Liu, C. Cytokines: From Clinical Significance to Quantification / C. Liu, D. Chu, K. Kalantar‐Zadeh // Advanced Science. – 2021. – No. 8 (15). – P. 4–32. DOI: 10.1002/advs.202004433
13. Podstawski, R. The influence of extreme thermal stress on the physiological and psychological characteristics of young women who sporadically use the sauna: practical implications for the safe use of the sauna / R. Podstawski, K. Boryslawski, N.M. Jokefacka // Public Health. Environmental health and Exposome. – 2023. – P. 3–15. DOI: 10.3389/fpubh.2023.1303804
14. Residual effects of short-term whole-body cold-water immersion on the cytokine profile, white blood cell count, and blood markers of stress / M. Eimonte, H. Paulauskas, L. Daniuseviciute et al. // International Journal of Hyperthermia. – 2021. – Vol. 38 (1). – P. 696–707. DOI: 10.1080/02656736.2021.1915504
15. The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise / J.M. Peake, L.A. Roberts, V.C. Figueiredo et al. // The journal of physiology. – 2017. – Vol. 595 (3). – P. 695–711. DOI: 10.1113/JP272881
16. Versteeg, N. Effects of 3-week repeated cold water immersion on leukocyte counts and cardio-vascular factors: an exploratory study / N. Versteeg, R. Clijsen, E. Hohenauer // Frontiers in Physiology. – 2023. – Vol. 14. – P. 9. DOI: 10.3389/fphys.2023.1197585
17. Wang, H. Regulation of Energy Balance by Inflammation: Common Theme in Physiology and Pathology / H. Wang, J. Ye // Reviews in endocrine and metabolic disorders. – 2015. – Vol. 16 (1). – P. 47–54. DOI: 10.1007/s11154-014-9306-8
18. White, G. E. The effect of various cold-water immersion protocols on exercise-induced inflammatory response and functional recovery from high-intensity sprint exercise / G.E. White, S.G. Rhind, G.D. Wells // European Journal of Applied Physiology. – 2014. – Vol. 114. – P. 2353–2367. DOI: 10.1007/s00421-014-2954-2
2. Tereshchenko I.V., Kayushev P.E. [Tumor Necrosis Factor α and its Role in Pathology]. Russkiy meditsinskiy zhurnal: Meditsinskoye obozreniye [Russian Medical Journal. Medical Review], 2022, no. 6 (9), pp. 523–527. (in Russ.) DOI: 10.32364/2587-6821-2022-6-9-523-527
3. Fisher T.A. Dremina E.L., Bobreshova S.S. Metodologiya zakalivaniya v doshkolnom obra-zovatelnom uchrezhdenii [The Methodology of Hardening in Preschool Educational Institution]. Novosibirsk, Siberian Branch of the Russian Academy of Sciences Publ., 2022. 100 p.
4. Chernova E.D. Znacheniye zakalivaniya dlya zdorov’ya cheloveka [The Importance of Hardening for Human Health]. E-SCIO Publ., 2021, pp. 6–13.
5. Selvasekar S., Priya M., Lakshmi S., Muralidharan S. A Review on Physiological Changes Associated with Cold Water Exposure. International Journal of Creative Research Thoughts, 2021, vol. 9 (8), pp. 45–53.
6. Banfi G., Lombardi G., Colombini A. Whole-body Cryotherapy in Athletes. Sports Medicine, 2012, vol. 40, pp. 509–517. DOI: 10.2165/11531940-0000000000-00000
7. Strieter R.M., Kasahara K., Allen R.M., Standiford T.J. et al. Cytokine-induced Neutrophil-derived Interleukin-8. American Journal of Pathology, 1992, vol. 141 (2), pp. 397–407.
8. Diehl S., Ricon M. The Two Faces of IL-6 on Th1/Th2 Differentiation. Molecular Immunology, 2002, vol. 39 (9), pp. 531–536. DOI: 10.1016/S0161-5890(02)00210-9
9. Dugue B., Leppänen E. Adaptation Related to Cytokines in Man: Effects of Regular Swimming in Ice-cold Water. Clinical Physiology, 2000, no. 20 (2), pp. 114–121. DOI: 10.1046/j.1365-2281.2000.00235.x
10. Jansky L., Pospilova D., Honzova S., Ulicny B. et al. Immune System of Cold-exposed and Cold-adapted Humans. European Journal of Applied Physiology and Occupational Physiology, 1996, no. 72 (5–6), pp. 445–450. DOI: 10.1007/BF00242274
11. Aliyu M., Zohora F., Anka A.U. et al. Interleukin-6 Cytokine: An Overview of the Immune Regulation, Immune Dysregulation, and Therapeutic Approach. International Immunopharmacology, 2022, vol. 111, pp. 109–130. DOI: 10.1016/j.intimp.2022.109130
12. Liu C., Chu D., Kalantar‐Zadeh K. Cytokines: From Clinical Significance to Quantification. Advanced Science, 2021, no. 8 (15), pp. 4–32. DOI: 10.1002/advs.202004433
13. Podstawski R., Boryslawski K., Jokefacka N.M. The Influence of Extreme Thermal Stress on the Physiological and Psychological Characteristics of Young Women who Sporadically Use the Sauna: Practical Implications for the Safe Use of the Sauna. Public Health. Environmental health and Exposome, 2023, pp. 3–15. DOI: 10.3389/fpubh.2023.1303804
14. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal of Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736.2021.1915504
15. Peake J.M., Roberts L.A., Figueiredo V.C. et al. The Effects of Cold Water Immersion and Active Recovery on Inflammation and Cell Stress Responses in Human Skeletal Muscle After Re-sistance Exercise. The Journal of Physiology, 2017, vol. 595 (3), pp. 695–711. DOI: 10.1113/JP272881
16. Versteeg N., Clijsen R., Hohenauer E. Effects of 3-week Repeated Cold Water Immersion on Leukocyte Counts and Cardiovascular Factors: an Exploratory Study. Frontiers in Physiology, 2023, vol. 14, pp. 8–16. DOI: 10.3389/fphys.2023.1197585
17. Wang H., Ye J. Regulation of Energy Balance by Inflammation: Common Theme in Physiology and Pathology. Reviews in Endocrine and Metabolic Disorders, 2015, vol. 16 (1), pp. 47–54. DOI: 10.1007/s11154-014-9306-8
18. White G.E., Rhind S.G., Wells G.D. The Effect of Various Cold-water Immersion Protocols on Exerciseinduced Inflammatory Response and Functional Recovery from High-intensity Sprint Exercise. European Journal of Applied Physiology, 2014, vol. 114, pp. 2353–2367. DOI: 10.1007/s00421-014-2954-2
2. Терещенко, И.В. Фактор некроза опухоли α и его роль в патологии / И.В. Терещенко, П.Е. Каюшев // Рус. мед. журнал. Мед. обозрение. – 2022. – № 6 (9). – С. 523–527. DOI: 10.32364/2587-6821-2022-6-9-523-527
3. Фишер, Т.А. Методология закаливания в дошкольном образовательном учреждении / Т.А. Фишер, Е.Л. Дремина, С.С. Бобрешова. – Новосибирск: СО РАН, 2022. – 100 с.
4. Чернова, Е.Д. Значение закаливания для здоровья человека / Е.Д. Чернова // E-SCIO. – 2021. – С. 6–13.
5. A Review on Physiological Changes Associated with Cold Water Exposure / S.Selvasekar, M.Priya, S. Lakshmi, S.Muralidharan // International Journal of Creative Research Thoughts. – 2021. – Vol. 9 (8). – P. 45–53.
6. Banfi, G. Whole-body cryotherapy in athletes / G. Banfi, G. Lombardi, A. Colombini // Sports Medicine. – 2012. – Vol. 40. – P. 509–517. DOI: 10.2165/11531940-0000000000-00000
7. Cytokine-induced Neutrophil-derived I nterleukin-8 / R.M. Strieter, K. Kasahara, R.M. Allen et al. // American Journal of Pathology. – 1992. – Vol. 141 (2). – P. 397–407.
8. Diehl, S. The two faces of IL-6 on Th1/Th2 differentiation / S. Diehl, M. Ricon // Molecular Immunology. – 2002. – Vol. 39 (9). – P. 531–536. DOI: 10.1016/S0161-5890(02)00210-9
9. Dugue, B. Adaptation related to cytokines in man: Effects of regular swimming in ice-cold water / B. Dugue, E. Leppänen // Clinical Physiology. – 2000. – No. 20 (2). – P. 114–121. DOI: 10.1046/j.1365-2281.2000.00235.x
10. Immune system of cold-exposed and cold-adapted humans / L. Jansky, D. Pospilova, S. Honzova et al. // European journal of applied physiology and occupational physiology. – 1996. – No. 72 (5-6). – P. 445–450. DOI: 10.1007/BF00242274
11. Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach / M. Aliyu, F. Zohora, A.U. Anka et al. // International Immunopharmacology. – 2022. – Vol. 111. – P. 109–130. DOI: 10.1016/j.intimp.2022.109130
12. Liu, C. Cytokines: From Clinical Significance to Quantification / C. Liu, D. Chu, K. Kalantar‐Zadeh // Advanced Science. – 2021. – No. 8 (15). – P. 4–32. DOI: 10.1002/advs.202004433
13. Podstawski, R. The influence of extreme thermal stress on the physiological and psychological characteristics of young women who sporadically use the sauna: practical implications for the safe use of the sauna / R. Podstawski, K. Boryslawski, N.M. Jokefacka // Public Health. Environmental health and Exposome. – 2023. – P. 3–15. DOI: 10.3389/fpubh.2023.1303804
14. Residual effects of short-term whole-body cold-water immersion on the cytokine profile, white blood cell count, and blood markers of stress / M. Eimonte, H. Paulauskas, L. Daniuseviciute et al. // International Journal of Hyperthermia. – 2021. – Vol. 38 (1). – P. 696–707. DOI: 10.1080/02656736.2021.1915504
15. The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise / J.M. Peake, L.A. Roberts, V.C. Figueiredo et al. // The journal of physiology. – 2017. – Vol. 595 (3). – P. 695–711. DOI: 10.1113/JP272881
16. Versteeg, N. Effects of 3-week repeated cold water immersion on leukocyte counts and cardio-vascular factors: an exploratory study / N. Versteeg, R. Clijsen, E. Hohenauer // Frontiers in Physiology. – 2023. – Vol. 14. – P. 9. DOI: 10.3389/fphys.2023.1197585
17. Wang, H. Regulation of Energy Balance by Inflammation: Common Theme in Physiology and Pathology / H. Wang, J. Ye // Reviews in endocrine and metabolic disorders. – 2015. – Vol. 16 (1). – P. 47–54. DOI: 10.1007/s11154-014-9306-8
18. White, G. E. The effect of various cold-water immersion protocols on exercise-induced inflammatory response and functional recovery from high-intensity sprint exercise / G.E. White, S.G. Rhind, G.D. Wells // European Journal of Applied Physiology. – 2014. – Vol. 114. – P. 2353–2367. DOI: 10.1007/s00421-014-2954-2
References
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3. Fisher T.A. Dremina E.L., Bobreshova S.S. Metodologiya zakalivaniya v doshkolnom obra-zovatelnom uchrezhdenii [The Methodology of Hardening in Preschool Educational Institution]. Novosibirsk, Siberian Branch of the Russian Academy of Sciences Publ., 2022. 100 p.
4. Chernova E.D. Znacheniye zakalivaniya dlya zdorov’ya cheloveka [The Importance of Hardening for Human Health]. E-SCIO Publ., 2021, pp. 6–13.
5. Selvasekar S., Priya M., Lakshmi S., Muralidharan S. A Review on Physiological Changes Associated with Cold Water Exposure. International Journal of Creative Research Thoughts, 2021, vol. 9 (8), pp. 45–53.
6. Banfi G., Lombardi G., Colombini A. Whole-body Cryotherapy in Athletes. Sports Medicine, 2012, vol. 40, pp. 509–517. DOI: 10.2165/11531940-0000000000-00000
7. Strieter R.M., Kasahara K., Allen R.M., Standiford T.J. et al. Cytokine-induced Neutrophil-derived Interleukin-8. American Journal of Pathology, 1992, vol. 141 (2), pp. 397–407.
8. Diehl S., Ricon M. The Two Faces of IL-6 on Th1/Th2 Differentiation. Molecular Immunology, 2002, vol. 39 (9), pp. 531–536. DOI: 10.1016/S0161-5890(02)00210-9
9. Dugue B., Leppänen E. Adaptation Related to Cytokines in Man: Effects of Regular Swimming in Ice-cold Water. Clinical Physiology, 2000, no. 20 (2), pp. 114–121. DOI: 10.1046/j.1365-2281.2000.00235.x
10. Jansky L., Pospilova D., Honzova S., Ulicny B. et al. Immune System of Cold-exposed and Cold-adapted Humans. European Journal of Applied Physiology and Occupational Physiology, 1996, no. 72 (5–6), pp. 445–450. DOI: 10.1007/BF00242274
11. Aliyu M., Zohora F., Anka A.U. et al. Interleukin-6 Cytokine: An Overview of the Immune Regulation, Immune Dysregulation, and Therapeutic Approach. International Immunopharmacology, 2022, vol. 111, pp. 109–130. DOI: 10.1016/j.intimp.2022.109130
12. Liu C., Chu D., Kalantar‐Zadeh K. Cytokines: From Clinical Significance to Quantification. Advanced Science, 2021, no. 8 (15), pp. 4–32. DOI: 10.1002/advs.202004433
13. Podstawski R., Boryslawski K., Jokefacka N.M. The Influence of Extreme Thermal Stress on the Physiological and Psychological Characteristics of Young Women who Sporadically Use the Sauna: Practical Implications for the Safe Use of the Sauna. Public Health. Environmental health and Exposome, 2023, pp. 3–15. DOI: 10.3389/fpubh.2023.1303804
14. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal of Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736.2021.1915504
15. Peake J.M., Roberts L.A., Figueiredo V.C. et al. The Effects of Cold Water Immersion and Active Recovery on Inflammation and Cell Stress Responses in Human Skeletal Muscle After Re-sistance Exercise. The Journal of Physiology, 2017, vol. 595 (3), pp. 695–711. DOI: 10.1113/JP272881
16. Versteeg N., Clijsen R., Hohenauer E. Effects of 3-week Repeated Cold Water Immersion on Leukocyte Counts and Cardiovascular Factors: an Exploratory Study. Frontiers in Physiology, 2023, vol. 14, pp. 8–16. DOI: 10.3389/fphys.2023.1197585
17. Wang H., Ye J. Regulation of Energy Balance by Inflammation: Common Theme in Physiology and Pathology. Reviews in Endocrine and Metabolic Disorders, 2015, vol. 16 (1), pp. 47–54. DOI: 10.1007/s11154-014-9306-8
18. White G.E., Rhind S.G., Wells G.D. The Effect of Various Cold-water Immersion Protocols on Exerciseinduced Inflammatory Response and Functional Recovery from High-intensity Sprint Exercise. European Journal of Applied Physiology, 2014, vol. 114, pp. 2353–2367. DOI: 10.1007/s00421-014-2954-2
Опубликован
2026-01-23
Как цитировать
Булашева, Е., Шалабодов, А., & Ральченко, И. (2026). ВЛИЯНИЕ ЗАКАЛИВАЮЩИХ ПРОЦЕДУР НА ИММУНОЛОГИЧЕСКИЕ ПОКАЗАТЕЛИ И ПОКАЗАТЕЛИ БЕЛОЙ КРОВИ ДЕТЕЙ 4–6 ЛЕТ. Человек. Спорт. Медицина, 25(S2), 38-44. https://doi.org/10.14529/hsm25s205
Выпуск
Раздел
Физиология
