БАЙЕСОВСКИЙ СЕТЕВОЙ МЕТААНАЛИЗ ЭФФЕКТОВ РАЗЛИЧНЫХ ТРЕНИРОВОЧНЫХ ПРОГРАММ НА МЕТАБОЛИЗМ ЖИРОВОЙ ТКАНИ У МЫШЕЙ С ДИАБЕТОМ 2-го ТИПА
Ключевые слова:
физические упражнения, диабет 2-го типа, липидный метаболизм, сетевой метаанализ, инсулинорезистентность
Аннотация
Цель: сравнить влияние различных тренировочных программ на экспрессию ключевых генов метаболизма жировой ткани у мышей с диабетом 2-го типа. Материалы и методы. Проведен систематический поиск в международных базах данных, включая Web of Science. Байесовский сетевой метаанализ выполнен с использованием Stata 16.0. Оценивались уровни экспрессии UCP-1, PGC-1α, PRDM-16, CIDEA и индекс HOMA-IR. Результаты. В анализ включено 24 исследования с участием 526 мышей. Физические нагрузки способствовали активации термогенных и метаболических генов. Длительные регулярные аэробные тренировки приводили к наиболее выраженному увеличению UCP-1 и PGC-1α, что отражает усиление митохондриальной активности. Плавание демонстрировало максимальный эффект на повышение PRDM-16 и снижение HOMA-IR, а высокоинтенсивные интервальные тренировки в большей степени влияли на массу тела. Заключение. Полученные данные подтверждают, что длительные аэробные тренировки, плавание и высокоинтенсивные интервальные нагрузки являются эффективными стратегиями модуляции метаболизма жировой ткани и показателей инсулинорезистентности у мышей с диабетом 2-го типа. Результаты могут служить основой для дальнейших экспериментальных исследований, направленных на уточнение механизмов адаптации жировой ткани к физической нагрузке.
Литература
1. Boström P., Wu J., Jedrychowski M.P. et al. A PGC1-α-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis. Nature, 2012, vol. 481, no. 7382, pp. 463–468. DOI: 10.1038/nature10777
2. Cannon B., Nedergaard J. Brown Adipose Tissue: Function and Physiological Significance. Physiological Reviews, 2004, vol. 84, no. 1, pp. 277–359. DOI: 10.1152/physrev.00015.2003
3. Chen K.Y., Brychta R.J., Abdul Sater Z. et al. Opportunities and Challenges in the Therapeutic Activation of Human Energy Expenditure and Thermogenesis to Manage Obesity. Journal of Biological Chemistry, 2020, vol. 295, no. 7, pp. 1926–1942. DOI: 10.1074/jbc.REV119.007363
4. Chow L.S., Gerszten R.E., Taylor J.M. et al. Exerkines in Health, Resilience and Disease. Nature Reviews Endocrinology, 2022, vol. 18, no. 5, pp. 273–289. DOI: 10.1038/s41574-022-00641-2
5. De Matteis R., Lucertini F., Guescini M. et al. Exercise as a New Physiological Stimulus for Brown Adipose Tissue Activity. Nutrition, Metabolism and Cardiovascular Diseases, 2013, vol. 23, no. 6, pp. 582–590. DOI: 10.1016/j.numecd.2012.01.013
6. Fisher F.M., Kleiner S., Douris N. et al. FGF21 Regulates PGC-1α and Browning of White Adipose Tissues in Adaptive Thermogenesis. Genes & Development, 2012, vol. 26, no. 3, pp. 271–281. DOI: 10.1101/gad.177857.111
7. Ghiasi R., Naderi R., Sheervalilou R., Alipour M.R. Swimming Training by Affecting the Pancreatic Sirtuin1 (SIRT1) and Oxidative Stress, Improves Insulin Sensitivity in Diabetic Male Rats. Hormone and Molecular Biology and Clinical Investigation, 2019, vol. 40, no. 3. DOI: 10.1515/hmbci-2019-0011
8. Ikeda K., Yamada T. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes. Frontiers in Endocrinology, 2020, vol. 11, art. 498. DOI: 10.3389/fendo.2020.00498
9. Kanaley J.A., Colberg S.R., Corcoran M.H. et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 2022, vol. 54, no. 2, pp. 353–368. DOI: 10.1249/mss.0000000000002800
10. Liubaoerjijin Y., Terada T., Fletcher K., Boulé N.G. Effect of Aerobic Exercise Intensity on Glycemic Control in Type 2 Diabetes: a Meta-analysis of Head-to-head Randomized Trials. Acta Diabetologica, 2016, vol. 53, no. 5, pp. 769–781. DOI: 10.1007/s00592-016-0870-0
11. Mirtajaddini-Goki M., Abbaspour M., Kordestani Z., Yeganeh-Hajahmadi M. Effects of Two Types of Exercises on MCT1 and GLUT4 Expression in Visceral White Adipose Tissue in Type I Diabetic Rats. Indian Journal of Experimental Biology, 2024, vol. 62, no. 5. DOI: 10.56042/ijeb.v62i05.1477
12. Motiani P., Virtanen K.A., Motiani K.K. et al. Decreased Insulin-stimulated Brown Adi-pose Tissue Glucose Uptake After Short-term Exercise Training in Healthy Middle-aged Men. Diabetes, Obesity and Metabolism, 2017, vol. 19, no. 10, pp. 1379–1388. DOI: 10.1111/dom.12947
13. Pold R., Jensen L.S., Jessen N. et al. Long-term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats. Diabetes, 2005, vol. 54, no. 4, pp. 928–934. DOI: 10.2337/diabetes.54.4.928
14. Rahman M.M., Kwon H.S., Kim M.J. et al. Melatonin Supplementation Plus Exercise Behavior Ameliorate Insulin Resistance, Hypertension and Fatigue in a Rat Model of Type 2 Diabetes Mellitus. Biomedicine & Pharmacotherapy, 2017, vol. 92, pp. 606–614. DOI: 10.1016/j.biopha.2017.05.035
15. Rajakumari S., Wu J., Ishibashi J. et al. EBF2 Determines and Maintains Brown Adipocyte Identity. Cell Metabolism, 2013, vol. 17, no. 4, pp. 562–574. DOI: 10.1016/j.cmet.2013.01.015
16. Ringholm S., Grunnet Knudsen J., Leick L. et al. PGC-1α is Required for Exercise- and Exercise Training-induced UCP1 Up-regulation in Mouse White Adipose Tissue. PLoS ONE, 2013, vol. 8, no. 5, e64123. DOI: 10.1371/journal.pone.0064123
17. Samsudeen H., Shree Pavithra De Varaj, Kandasamy K. Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus. Current Diabetes Reviews, 2024. DOI: 10.2174/0115733998275876240125064716
18. Schlein C., Talukdar S., Heine M. et al. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metabolism, 2016, vol. 23, no. 3, pp. 441–453. DOI: 10.1016/j.cmet.2016.01.006
19. Seale P., Conroe H.M., Estall J. et al. Prdm16 Determines the Thermogenic Program of Subcutaneous White Adipose Tissue in Mice. Journal of Clinical Investigation, 2011, vol. 121, no. 1, pp. 96–105. DOI: 10.1172/jci44271
20. Teixeira de Lemos E., Pinto R., Oliveira J. et al. Differential Effects of Acute (Extenuat-ing) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation, 2011, vol. 2011, art. 253061. DOI: 10.1155/2011/253061
21. Tjønna A.E., Lee S.J., Rognmo Ø. et al. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: a Pilot Study. Circulation, 2008, vol. 118, no. 4, pp. 346–354. DOI: 10.1161/circulationaha.108.772822
22. Uldry M., Yang W., St-Pierre J. et al. Complementary Action of the PGC-1 Coactivators in Mitochondrial Biogenesis and Brown Fat Differentiation. Cell Metabolism, 2006, vol. 3, no. 5, pp. 333–341. DOI: 10.1016/j.cmet.2006.04.002
23. Wang N., Liu Y., Ma Y., Wen D. High-intensity Interval Versus Moderate-intensity Continuous Training: Superior Metabolic Benefits in Diet-induced Obesity Mice. Life Sciences, 2017, vol. 191, pp. 122–131. DOI: 10.1016/j.lfs.2017.08.023
2. Cannon B., Nedergaard J. Brown Adipose Tissue: Function and Physiological Significance. Physiological Reviews, 2004, vol. 84, no. 1, pp. 277–359. DOI: 10.1152/physrev.00015.2003
3. Chen K.Y., Brychta R.J., Abdul Sater Z. et al. Opportunities and Challenges in the Therapeutic Activation of Human Energy Expenditure and Thermogenesis to Manage Obesity. Journal of Biological Chemistry, 2020, vol. 295, no. 7, pp. 1926–1942. DOI: 10.1074/jbc.REV119.007363
4. Chow L.S., Gerszten R.E., Taylor J.M. et al. Exerkines in Health, Resilience and Disease. Nature Reviews Endocrinology, 2022, vol. 18, no. 5, pp. 273–289. DOI: 10.1038/s41574-022-00641-2
5. De Matteis R., Lucertini F., Guescini M. et al. Exercise as a New Physiological Stimulus for Brown Adipose Tissue Activity. Nutrition, Metabolism and Cardiovascular Diseases, 2013, vol. 23, no. 6, pp. 582–590. DOI: 10.1016/j.numecd.2012.01.013
6. Fisher F.M., Kleiner S., Douris N. et al. FGF21 Regulates PGC-1α and Browning of White Adipose Tissues in Adaptive Thermogenesis. Genes & Development, 2012, vol. 26, no. 3, pp. 271–281. DOI: 10.1101/gad.177857.111
7. Ghiasi R., Naderi R., Sheervalilou R., Alipour M.R. Swimming Training by Affecting the Pancreatic Sirtuin1 (SIRT1) and Oxidative Stress, Improves Insulin Sensitivity in Diabetic Male Rats. Hormone and Molecular Biology and Clinical Investigation, 2019, vol. 40, no. 3. DOI: 10.1515/hmbci-2019-0011
8. Ikeda K., Yamada T. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes. Frontiers in Endocrinology, 2020, vol. 11, art. 498. DOI: 10.3389/fendo.2020.00498
9. Kanaley J.A., Colberg S.R., Corcoran M.H. et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 2022, vol. 54, no. 2, pp. 353–368. DOI: 10.1249/mss.0000000000002800
10. Liubaoerjijin Y., Terada T., Fletcher K., Boulé N.G. Effect of Aerobic Exercise Intensity on Glycemic Control in Type 2 Diabetes: a Meta-analysis of Head-to-head Randomized Trials. Acta Diabetologica, 2016, vol. 53, no. 5, pp. 769–781. DOI: 10.1007/s00592-016-0870-0
11. Mirtajaddini-Goki M., Abbaspour M., Kordestani Z., Yeganeh-Hajahmadi M. Effects of Two Types of Exercises on MCT1 and GLUT4 Expression in Visceral White Adipose Tissue in Type I Diabetic Rats. Indian Journal of Experimental Biology, 2024, vol. 62, no. 5. DOI: 10.56042/ijeb.v62i05.1477
12. Motiani P., Virtanen K.A., Motiani K.K. et al. Decreased Insulin-stimulated Brown Adi-pose Tissue Glucose Uptake After Short-term Exercise Training in Healthy Middle-aged Men. Diabetes, Obesity and Metabolism, 2017, vol. 19, no. 10, pp. 1379–1388. DOI: 10.1111/dom.12947
13. Pold R., Jensen L.S., Jessen N. et al. Long-term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats. Diabetes, 2005, vol. 54, no. 4, pp. 928–934. DOI: 10.2337/diabetes.54.4.928
14. Rahman M.M., Kwon H.S., Kim M.J. et al. Melatonin Supplementation Plus Exercise Behavior Ameliorate Insulin Resistance, Hypertension and Fatigue in a Rat Model of Type 2 Diabetes Mellitus. Biomedicine & Pharmacotherapy, 2017, vol. 92, pp. 606–614. DOI: 10.1016/j.biopha.2017.05.035
15. Rajakumari S., Wu J., Ishibashi J. et al. EBF2 Determines and Maintains Brown Adipocyte Identity. Cell Metabolism, 2013, vol. 17, no. 4, pp. 562–574. DOI: 10.1016/j.cmet.2013.01.015
16. Ringholm S., Grunnet Knudsen J., Leick L. et al. PGC-1α is Required for Exercise- and Exercise Training-induced UCP1 Up-regulation in Mouse White Adipose Tissue. PLoS ONE, 2013, vol. 8, no. 5, e64123. DOI: 10.1371/journal.pone.0064123
17. Samsudeen H., Shree Pavithra De Varaj, Kandasamy K. Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus. Current Diabetes Reviews, 2024. DOI: 10.2174/0115733998275876240125064716
18. Schlein C., Talukdar S., Heine M. et al. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metabolism, 2016, vol. 23, no. 3, pp. 441–453. DOI: 10.1016/j.cmet.2016.01.006
19. Seale P., Conroe H.M., Estall J. et al. Prdm16 Determines the Thermogenic Program of Subcutaneous White Adipose Tissue in Mice. Journal of Clinical Investigation, 2011, vol. 121, no. 1, pp. 96–105. DOI: 10.1172/jci44271
20. Teixeira de Lemos E., Pinto R., Oliveira J. et al. Differential Effects of Acute (Extenuat-ing) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation, 2011, vol. 2011, art. 253061. DOI: 10.1155/2011/253061
21. Tjønna A.E., Lee S.J., Rognmo Ø. et al. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: a Pilot Study. Circulation, 2008, vol. 118, no. 4, pp. 346–354. DOI: 10.1161/circulationaha.108.772822
22. Uldry M., Yang W., St-Pierre J. et al. Complementary Action of the PGC-1 Coactivators in Mitochondrial Biogenesis and Brown Fat Differentiation. Cell Metabolism, 2006, vol. 3, no. 5, pp. 333–341. DOI: 10.1016/j.cmet.2006.04.002
23. Wang N., Liu Y., Ma Y., Wen D. High-intensity Interval Versus Moderate-intensity Continuous Training: Superior Metabolic Benefits in Diet-induced Obesity Mice. Life Sciences, 2017, vol. 191, pp. 122–131. DOI: 10.1016/j.lfs.2017.08.023
2. Cannon B., Nedergaard J. Brown Adipose Tissue: Function and Physiological Significance. Physiological Reviews, 2004, vol. 84, no. 1, pp. 277–359. DOI: 10.1152/physrev.00015.2003
3. Chen K.Y., Brychta R.J., Abdul Sater Z. et al. Opportunities and Challenges in the Therapeutic Activation of Human Energy Expenditure and Thermogenesis to Manage Obesity. Journal of Biological Chemistry, 2020, vol. 295, no. 7, pp. 1926–1942. DOI: 10.1074/jbc.REV119.007363
4. Chow L.S., Gerszten R.E., Taylor J.M. et al. Exerkines in Health, Resilience and Disease. Nature Reviews Endocrinology, 2022, vol. 18, no. 5, pp. 273–289. DOI: 10.1038/s41574-022-00641-2
5. De Matteis R., Lucertini F., Guescini M. et al. Exercise as a New Physiological Stimulus for Brown Adipose Tissue Activity. Nutrition, Metabolism and Cardiovascular Diseases, 2013, vol. 23, no. 6, pp. 582–590. DOI: 10.1016/j.numecd.2012.01.013
6. Fisher F.M., Kleiner S., Douris N. et al. FGF21 Regulates PGC-1α and Browning of White Adipose Tissues in Adaptive Thermogenesis. Genes & Development, 2012, vol. 26, no. 3, pp. 271–281. DOI: 10.1101/gad.177857.111
7. Ghiasi R., Naderi R., Sheervalilou R., Alipour M.R. Swimming Training by Affecting the Pancreatic Sirtuin1 (SIRT1) and Oxidative Stress, Improves Insulin Sensitivity in Diabetic Male Rats. Hormone and Molecular Biology and Clinical Investigation, 2019, vol. 40, no. 3. DOI: 10.1515/hmbci-2019-0011
8. Ikeda K., Yamada T. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes. Frontiers in Endocrinology, 2020, vol. 11, art. 498. DOI: 10.3389/fendo.2020.00498
9. Kanaley J.A., Colberg S.R., Corcoran M.H. et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 2022, vol. 54, no. 2, pp. 353–368. DOI: 10.1249/mss.0000000000002800
10. Liubaoerjijin Y., Terada T., Fletcher K., Boulé N.G. Effect of Aerobic Exercise Intensity on Glycemic Control in Type 2 Diabetes: a Meta-analysis of Head-to-head Randomized Trials. Acta Diabetologica, 2016, vol. 53, no. 5, pp. 769–781. DOI: 10.1007/s00592-016-0870-0
11. Mirtajaddini-Goki M., Abbaspour M., Kordestani Z., Yeganeh-Hajahmadi M. Effects of Two Types of Exercises on MCT1 and GLUT4 Expression in Visceral White Adipose Tissue in Type I Diabetic Rats. Indian Journal of Experimental Biology, 2024, vol. 62, no. 5. DOI: 10.56042/ijeb.v62i05.1477
12. Motiani P., Virtanen K.A., Motiani K.K. et al. Decreased Insulin-stimulated Brown Adi-pose Tissue Glucose Uptake After Short-term Exercise Training in Healthy Middle-aged Men. Diabetes, Obesity and Metabolism, 2017, vol. 19, no. 10, pp. 1379–1388. DOI: 10.1111/dom.12947
13. Pold R., Jensen L.S., Jessen N. et al. Long-term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats. Diabetes, 2005, vol. 54, no. 4, pp. 928–934. DOI: 10.2337/diabetes.54.4.928
14. Rahman M.M., Kwon H.S., Kim M.J. et al. Melatonin Supplementation Plus Exercise Behavior Ameliorate Insulin Resistance, Hypertension and Fatigue in a Rat Model of Type 2 Diabetes Mellitus. Biomedicine & Pharmacotherapy, 2017, vol. 92, pp. 606–614. DOI: 10.1016/j.biopha.2017.05.035
15. Rajakumari S., Wu J., Ishibashi J. et al. EBF2 Determines and Maintains Brown Adipocyte Identity. Cell Metabolism, 2013, vol. 17, no. 4, pp. 562–574. DOI: 10.1016/j.cmet.2013.01.015
16. Ringholm S., Grunnet Knudsen J., Leick L. et al. PGC-1α is Required for Exercise- and Exercise Training-induced UCP1 Up-regulation in Mouse White Adipose Tissue. PLoS ONE, 2013, vol. 8, no. 5, e64123. DOI: 10.1371/journal.pone.0064123
17. Samsudeen H., Shree Pavithra De Varaj, Kandasamy K. Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus. Current Diabetes Reviews, 2024. DOI: 10.2174/0115733998275876240125064716
18. Schlein C., Talukdar S., Heine M. et al. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metabolism, 2016, vol. 23, no. 3, pp. 441–453. DOI: 10.1016/j.cmet.2016.01.006
19. Seale P., Conroe H.M., Estall J. et al. Prdm16 Determines the Thermogenic Program of Subcutaneous White Adipose Tissue in Mice. Journal of Clinical Investigation, 2011, vol. 121, no. 1, pp. 96–105. DOI: 10.1172/jci44271
20. Teixeira de Lemos E., Pinto R., Oliveira J. et al. Differential Effects of Acute (Extenuat-ing) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation, 2011, vol. 2011, art. 253061. DOI: 10.1155/2011/253061
21. Tjønna A.E., Lee S.J., Rognmo Ø. et al. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: a Pilot Study. Circulation, 2008, vol. 118, no. 4, pp. 346–354. DOI: 10.1161/circulationaha.108.772822
22. Uldry M., Yang W., St-Pierre J. et al. Complementary Action of the PGC-1 Coactivators in Mitochondrial Biogenesis and Brown Fat Differentiation. Cell Metabolism, 2006, vol. 3, no. 5, pp. 333–341. DOI: 10.1016/j.cmet.2006.04.002
23. Wang N., Liu Y., Ma Y., Wen D. High-intensity Interval Versus Moderate-intensity Continuous Training: Superior Metabolic Benefits in Diet-induced Obesity Mice. Life Sciences, 2017, vol. 191, pp. 122–131. DOI: 10.1016/j.lfs.2017.08.023
References
1. Boström P., Wu J., Jedrychowski M.P. et al. A PGC1-α-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis. Nature, 2012, vol. 481, no. 7382, pp. 463–468. DOI: 10.1038/nature107772. Cannon B., Nedergaard J. Brown Adipose Tissue: Function and Physiological Significance. Physiological Reviews, 2004, vol. 84, no. 1, pp. 277–359. DOI: 10.1152/physrev.00015.2003
3. Chen K.Y., Brychta R.J., Abdul Sater Z. et al. Opportunities and Challenges in the Therapeutic Activation of Human Energy Expenditure and Thermogenesis to Manage Obesity. Journal of Biological Chemistry, 2020, vol. 295, no. 7, pp. 1926–1942. DOI: 10.1074/jbc.REV119.007363
4. Chow L.S., Gerszten R.E., Taylor J.M. et al. Exerkines in Health, Resilience and Disease. Nature Reviews Endocrinology, 2022, vol. 18, no. 5, pp. 273–289. DOI: 10.1038/s41574-022-00641-2
5. De Matteis R., Lucertini F., Guescini M. et al. Exercise as a New Physiological Stimulus for Brown Adipose Tissue Activity. Nutrition, Metabolism and Cardiovascular Diseases, 2013, vol. 23, no. 6, pp. 582–590. DOI: 10.1016/j.numecd.2012.01.013
6. Fisher F.M., Kleiner S., Douris N. et al. FGF21 Regulates PGC-1α and Browning of White Adipose Tissues in Adaptive Thermogenesis. Genes & Development, 2012, vol. 26, no. 3, pp. 271–281. DOI: 10.1101/gad.177857.111
7. Ghiasi R., Naderi R., Sheervalilou R., Alipour M.R. Swimming Training by Affecting the Pancreatic Sirtuin1 (SIRT1) and Oxidative Stress, Improves Insulin Sensitivity in Diabetic Male Rats. Hormone and Molecular Biology and Clinical Investigation, 2019, vol. 40, no. 3. DOI: 10.1515/hmbci-2019-0011
8. Ikeda K., Yamada T. UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes. Frontiers in Endocrinology, 2020, vol. 11, art. 498. DOI: 10.3389/fendo.2020.00498
9. Kanaley J.A., Colberg S.R., Corcoran M.H. et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 2022, vol. 54, no. 2, pp. 353–368. DOI: 10.1249/mss.0000000000002800
10. Liubaoerjijin Y., Terada T., Fletcher K., Boulé N.G. Effect of Aerobic Exercise Intensity on Glycemic Control in Type 2 Diabetes: a Meta-analysis of Head-to-head Randomized Trials. Acta Diabetologica, 2016, vol. 53, no. 5, pp. 769–781. DOI: 10.1007/s00592-016-0870-0
11. Mirtajaddini-Goki M., Abbaspour M., Kordestani Z., Yeganeh-Hajahmadi M. Effects of Two Types of Exercises on MCT1 and GLUT4 Expression in Visceral White Adipose Tissue in Type I Diabetic Rats. Indian Journal of Experimental Biology, 2024, vol. 62, no. 5. DOI: 10.56042/ijeb.v62i05.1477
12. Motiani P., Virtanen K.A., Motiani K.K. et al. Decreased Insulin-stimulated Brown Adi-pose Tissue Glucose Uptake After Short-term Exercise Training in Healthy Middle-aged Men. Diabetes, Obesity and Metabolism, 2017, vol. 19, no. 10, pp. 1379–1388. DOI: 10.1111/dom.12947
13. Pold R., Jensen L.S., Jessen N. et al. Long-term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats. Diabetes, 2005, vol. 54, no. 4, pp. 928–934. DOI: 10.2337/diabetes.54.4.928
14. Rahman M.M., Kwon H.S., Kim M.J. et al. Melatonin Supplementation Plus Exercise Behavior Ameliorate Insulin Resistance, Hypertension and Fatigue in a Rat Model of Type 2 Diabetes Mellitus. Biomedicine & Pharmacotherapy, 2017, vol. 92, pp. 606–614. DOI: 10.1016/j.biopha.2017.05.035
15. Rajakumari S., Wu J., Ishibashi J. et al. EBF2 Determines and Maintains Brown Adipocyte Identity. Cell Metabolism, 2013, vol. 17, no. 4, pp. 562–574. DOI: 10.1016/j.cmet.2013.01.015
16. Ringholm S., Grunnet Knudsen J., Leick L. et al. PGC-1α is Required for Exercise- and Exercise Training-induced UCP1 Up-regulation in Mouse White Adipose Tissue. PLoS ONE, 2013, vol. 8, no. 5, e64123. DOI: 10.1371/journal.pone.0064123
17. Samsudeen H., Shree Pavithra De Varaj, Kandasamy K. Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus. Current Diabetes Reviews, 2024. DOI: 10.2174/0115733998275876240125064716
18. Schlein C., Talukdar S., Heine M. et al. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metabolism, 2016, vol. 23, no. 3, pp. 441–453. DOI: 10.1016/j.cmet.2016.01.006
19. Seale P., Conroe H.M., Estall J. et al. Prdm16 Determines the Thermogenic Program of Subcutaneous White Adipose Tissue in Mice. Journal of Clinical Investigation, 2011, vol. 121, no. 1, pp. 96–105. DOI: 10.1172/jci44271
20. Teixeira de Lemos E., Pinto R., Oliveira J. et al. Differential Effects of Acute (Extenuat-ing) and Chronic (Training) Exercise on Inflammation and Oxidative Stress Status in an Animal Model of Type 2 Diabetes Mellitus. Mediators of Inflammation, 2011, vol. 2011, art. 253061. DOI: 10.1155/2011/253061
21. Tjønna A.E., Lee S.J., Rognmo Ø. et al. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: a Pilot Study. Circulation, 2008, vol. 118, no. 4, pp. 346–354. DOI: 10.1161/circulationaha.108.772822
22. Uldry M., Yang W., St-Pierre J. et al. Complementary Action of the PGC-1 Coactivators in Mitochondrial Biogenesis and Brown Fat Differentiation. Cell Metabolism, 2006, vol. 3, no. 5, pp. 333–341. DOI: 10.1016/j.cmet.2006.04.002
23. Wang N., Liu Y., Ma Y., Wen D. High-intensity Interval Versus Moderate-intensity Continuous Training: Superior Metabolic Benefits in Diet-induced Obesity Mice. Life Sciences, 2017, vol. 191, pp. 122–131. DOI: 10.1016/j.lfs.2017.08.023
Опубликован
2026-10-07
Как цитировать
Юйфэнь, Ю., Дьякова, Е., Сяньбо, Ц., & Тунянь, Ч. (2026). БАЙЕСОВСКИЙ СЕТЕВОЙ МЕТААНАЛИЗ ЭФФЕКТОВ РАЗЛИЧНЫХ ТРЕНИРОВОЧНЫХ ПРОГРАММ НА МЕТАБОЛИЗМ ЖИРОВОЙ ТКАНИ У МЫШЕЙ С ДИАБЕТОМ 2-го ТИПА. Человек. Спорт. Медицина, 26(3), 24-31. https://doi.org/10.14529/hsm260303
Выпуск
Раздел
Физиология
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