ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ АЛЬФА-1-АДРЕНОРЕЦЕПТОРОВ АРТЕРИЙ К НОРЭПИНЕФРИНУ ПРИ СИМПАТОЛИЗИСЕ НА ФОНЕ 5-ДНЕВНОЙ ХОЛОДОВОЙ АДАПТАЦИИ
Ключевые слова:
кролики, 5-дневная холодовая адаптация, симпатолизис, электростимуляция мышц, норэпинефрин, а1-адренорецепторы артерий
Аннотация
Цель: исследовать механизмы реактивности а1-адренорецепторов артериальных сосудов на норэпинефрин при функциональном симпатолизисе после 5-дневной холодовой адаптации. Материалы и методы. Эксперименты были проведены в четырех группах кроликов. Первая группа – контрольная (n = 20), вторая (n = 15) – кролики с электростимуляцией мышц (симпатолизис), третья (n = 15) – кролики после 5 дней холодовой адаптации, четвертая (n = 15) – кролики с симпатолизисом на фоне 5 дней холодовой адаптации. У всех кроликов вместо сердца мышцы задней конечности перфузировали собственной кровью через бедренную артерию насосом постоянного расхода.
У всех кроликов после введения 8 возрастающих доз норэпинефрина по изменению перфузионного давления в бедренной артерии определяли активность а1-адренорецепторов артерий. Симпатолизис как уменьшение тонуса бедренной артерии при сокращении мышц, моделировали электростимуляцией мышц задней конечности. Полученные данные «доза – эффект» анализировались в двойных обратных координатах Lineweaver–Burk, что позволило определить чувствительность (1/К) а1-адренорецепторов к норэпинефрину и количество активных а1-адренорецепторов (Pm). Результаты. Исследование показало, что после 5 дней холодовой адаптации при симпатолизисе количество активных (Pm) а1-адренорецепторов артерий мышц значительно возросло – на 45,3 %, возросла и их чувствительность (1/К) на 42,8 % по сравнению с симпатолизисом без холода. Заключение. Эти механизмы увеличения количества активных а1-адренорецепторов и их количества позволяют организму после 5 дней холодовой адаптации при сокращении мышц значительно уменьшить в них кровоток, уменьшается прогрев тела и теплоотдача, сохраняется больше тепла при холоде. Но мышечная деятельность становится менее результативной, так как будет уменьшен кровоток в работающих мышцах.
Литература
1. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Значение адренорецепторов артерий при симпатолизисе в регуляции кровотока в работающих мышцах // Человек. Спорт. Медицина. 2023. Т. 23, № 2. С. 61–68. [Ananev V.N., Ananev G.V., Ananeva O.V. The Importance of Arterial Adrenoceptors in Sympatholysis in the Regulation of Blood Flow in Working Muscles. Human. Sport. Medicine, 2023, vol. 23 (2), pp. 61–68. (in Russ.)] DOI: 10.14529/hsm230208
2. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Функциональная регуляция адренорецепторов артерий при симпатолизисе в работающих мышцах на норэпинефрин при холодовой адаптации // Человек. Спорт. Медицина. 2024. Т. 24, № 2. С. 33–40. [Ananev V.N., Ananev G.V., Ananeva O.V. Functional Regulation of Artery Adrenoreceptors in Response to Norepi-nephrine Administration During Sympatholysis Following a 30-day Cold Adaptation in Working Muscles. Human. Sport. Medicine, 2024, vol. 24 (2), pp. 33–40. (in Russ.)] DOI: 10.14529/hsm240204
3. DeLorey D.S. Sympathetic Vasoconstriction in Skeletal Muscle: Modulatory Effects of Aging, Exercise Training, and Sex. Appl. Physiology, Nutr. Metabolism, 2021, vol. 46, pp. 1437–1447. DOI: 10.1139/apnm2021-0399
4. DeLorey D.S., Clifford P.S. Does Sympathetic Vasoconstriction Contribute to Metabolism: Perfusion Matching in Exercising Skeletal Muscle? Front Physiology, 2022, vol. 13, 980524. DOI: 10.3389/fphys.2022.980524
5. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736
6. Elsnicova B., Tibenska V., Galatik F. et al. Continuous Short-term Acclimation to Moderate Cold Elicits Cardioprotection in Rats, and Alters β-adrenergic Signaling and Immune Status. Science Rep., 2023, vol. 13 (1), 18287. DOI: 10.1038/s41598-023-44205-4
7. Gordon K., Blondin D.P., Friesen B.J. et al. Seven Days of Cold Acclimation Substantially Reduces Shivering Intensity and Increases Nonshivering Thermogenesis in Adult Humans. Journal Appl. Physiology, 2019, vol. 126 (6), pp. 1598–1606. DOI: 10.1152/japplphysiol.01133
8. Haman F., Souza S.C.S., Castellani J.W. et al. Human Vulnerability and Variability in the Cold: Establishing Individual Risks for Cold Weather Injuries. Temperature (Austin), 2022, vol. 9 (2), pp. 158–195. DOI: 10.1080/23328940.2022.2044740
9. Heinke L., Javanmardi S., Rappelt L. et al. Comparison of the Effects of Cold Water Immersion and Percussive Massage on the Recovery After Exhausting Eccentric Exercise: A Three-armed Randomized Controlled Trial. Front Physiology, 2024, vol. 15, 1432009. DOI: 10.3389/fphys.2024
10. Kelly K.R., Pautz C.M., Palombo L.J. et al. Altered Sympathoadrenal Activity Following Cold-Water Diving. Journal Spec Oper Med., 2023, vol. 23 (3), pp. 74–81. DOI: 10.55460/T5CZ-JXVK
11. Ni W., Stafoggia M., Zhang S. et al. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal American Coll. Cardiology, 2024, vol. 84 (13), pp. 1149–1159. DOI: 10.1016/j.jacc
12. Notley S.R., Mitchell D., Taylor N.A.S. A Century of Exercise Physiology: Concepts That Ignited the Study of Human Thermoregulation. Part 4: Evolution, Thermal Adaptation and Unsupported Theories of Thermoregulation. European Journal Appl Physiology, 2024, vol. 124 (1), pp. 147–218. DOI: 10.1007/s00421-023-05262-9
13. Tabuchi C., Sul H.S. Signaling Pathways Regulating Thermogenesis. Front Endocrinol (Lausanne), 2021, vol. 12, 595020. DOI: 10.3389/fendo.2021.595020
14. Tibenska V., Benesova A., Vebr P. et al. Gradual Cold Acclimation Induces Cardioprotection Without Affecting β-adrenergic Receptor-mediated Adenylyl Cyclase Signaling. Journal Appl. Physiology, 2020, vol. 128 (4), pp. 1023–1032. DOI: 10.1152/japplphysiol.00511.2019
15. Simpson L.L., Hansen A.B., Moralez G. et al. Adrenergic Control of Skeletal Muscle Blood Flow During Chronic Hypoxia in Healthy Males. American Journal Physiology Regulation Integr. Comp. Physiology, 2023, vol. 324 (4), pp. 457–469. DOI: 10.1152/ajpregu.00230.2022
16. Voronkov N.S., Popov S.V., Naryzhnaya N.V. et al. Effect Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury. Iran Biomed Journal, 2024, vol. 28 (2&3), pp. 59–70. DOI: 10.61186/ibj.3872
17. Yurkevicius B.R., Alba B.K., Seeley A.D., Castellani J.W. Human Cold Habituation: Physiology, Timeline, and Modifiers. Temperature (Austin), 2021, vol. 9 (2), pp. 122–157. DOI: 10.1080/23328940.2021.1903145
2. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Функциональная регуляция адренорецепторов артерий при симпатолизисе в работающих мышцах на норэпинефрин при холодовой адаптации // Человек. Спорт. Медицина. 2024. Т. 24, № 2. С. 33–40. [Ananev V.N., Ananev G.V., Ananeva O.V. Functional Regulation of Artery Adrenoreceptors in Response to Norepi-nephrine Administration During Sympatholysis Following a 30-day Cold Adaptation in Working Muscles. Human. Sport. Medicine, 2024, vol. 24 (2), pp. 33–40. (in Russ.)] DOI: 10.14529/hsm240204
3. DeLorey D.S. Sympathetic Vasoconstriction in Skeletal Muscle: Modulatory Effects of Aging, Exercise Training, and Sex. Appl. Physiology, Nutr. Metabolism, 2021, vol. 46, pp. 1437–1447. DOI: 10.1139/apnm2021-0399
4. DeLorey D.S., Clifford P.S. Does Sympathetic Vasoconstriction Contribute to Metabolism: Perfusion Matching in Exercising Skeletal Muscle? Front Physiology, 2022, vol. 13, 980524. DOI: 10.3389/fphys.2022.980524
5. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736
6. Elsnicova B., Tibenska V., Galatik F. et al. Continuous Short-term Acclimation to Moderate Cold Elicits Cardioprotection in Rats, and Alters β-adrenergic Signaling and Immune Status. Science Rep., 2023, vol. 13 (1), 18287. DOI: 10.1038/s41598-023-44205-4
7. Gordon K., Blondin D.P., Friesen B.J. et al. Seven Days of Cold Acclimation Substantially Reduces Shivering Intensity and Increases Nonshivering Thermogenesis in Adult Humans. Journal Appl. Physiology, 2019, vol. 126 (6), pp. 1598–1606. DOI: 10.1152/japplphysiol.01133
8. Haman F., Souza S.C.S., Castellani J.W. et al. Human Vulnerability and Variability in the Cold: Establishing Individual Risks for Cold Weather Injuries. Temperature (Austin), 2022, vol. 9 (2), pp. 158–195. DOI: 10.1080/23328940.2022.2044740
9. Heinke L., Javanmardi S., Rappelt L. et al. Comparison of the Effects of Cold Water Immersion and Percussive Massage on the Recovery After Exhausting Eccentric Exercise: A Three-armed Randomized Controlled Trial. Front Physiology, 2024, vol. 15, 1432009. DOI: 10.3389/fphys.2024
10. Kelly K.R., Pautz C.M., Palombo L.J. et al. Altered Sympathoadrenal Activity Following Cold-Water Diving. Journal Spec Oper Med., 2023, vol. 23 (3), pp. 74–81. DOI: 10.55460/T5CZ-JXVK
11. Ni W., Stafoggia M., Zhang S. et al. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal American Coll. Cardiology, 2024, vol. 84 (13), pp. 1149–1159. DOI: 10.1016/j.jacc
12. Notley S.R., Mitchell D., Taylor N.A.S. A Century of Exercise Physiology: Concepts That Ignited the Study of Human Thermoregulation. Part 4: Evolution, Thermal Adaptation and Unsupported Theories of Thermoregulation. European Journal Appl Physiology, 2024, vol. 124 (1), pp. 147–218. DOI: 10.1007/s00421-023-05262-9
13. Tabuchi C., Sul H.S. Signaling Pathways Regulating Thermogenesis. Front Endocrinol (Lausanne), 2021, vol. 12, 595020. DOI: 10.3389/fendo.2021.595020
14. Tibenska V., Benesova A., Vebr P. et al. Gradual Cold Acclimation Induces Cardioprotection Without Affecting β-adrenergic Receptor-mediated Adenylyl Cyclase Signaling. Journal Appl. Physiology, 2020, vol. 128 (4), pp. 1023–1032. DOI: 10.1152/japplphysiol.00511.2019
15. Simpson L.L., Hansen A.B., Moralez G. et al. Adrenergic Control of Skeletal Muscle Blood Flow During Chronic Hypoxia in Healthy Males. American Journal Physiology Regulation Integr. Comp. Physiology, 2023, vol. 324 (4), pp. 457–469. DOI: 10.1152/ajpregu.00230.2022
16. Voronkov N.S., Popov S.V., Naryzhnaya N.V. et al. Effect Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury. Iran Biomed Journal, 2024, vol. 28 (2&3), pp. 59–70. DOI: 10.61186/ibj.3872
17. Yurkevicius B.R., Alba B.K., Seeley A.D., Castellani J.W. Human Cold Habituation: Physiology, Timeline, and Modifiers. Temperature (Austin), 2021, vol. 9 (2), pp. 122–157. DOI: 10.1080/23328940.2021.1903145
2. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Функциональная регуляция адренорецепторов артерий при симпатолизисе в работающих мышцах на норэпинефрин при холодовой адаптации // Человек. Спорт. Медицина. 2024. Т. 24, № 2. С. 33–40. [Ananev V.N., Ananev G.V., Ananeva O.V. Functional Regulation of Artery Adrenoreceptors in Response to Norepi-nephrine Administration During Sympatholysis Following a 30-day Cold Adaptation in Working Muscles. Human. Sport. Medicine, 2024, vol. 24 (2), pp. 33–40. (in Russ.)] DOI: 10.14529/hsm240204
3. DeLorey D.S. Sympathetic Vasoconstriction in Skeletal Muscle: Modulatory Effects of Aging, Exercise Training, and Sex. Appl. Physiology, Nutr. Metabolism, 2021, vol. 46, pp. 1437–1447. DOI: 10.1139/apnm2021-0399
4. DeLorey D.S., Clifford P.S. Does Sympathetic Vasoconstriction Contribute to Metabolism: Perfusion Matching in Exercising Skeletal Muscle? Front Physiology, 2022, vol. 13, 980524. DOI: 10.3389/fphys.2022.980524
5. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736
6. Elsnicova B., Tibenska V., Galatik F. et al. Continuous Short-term Acclimation to Moderate Cold Elicits Cardioprotection in Rats, and Alters β-adrenergic Signaling and Immune Status. Science Rep., 2023, vol. 13 (1), 18287. DOI: 10.1038/s41598-023-44205-4
7. Gordon K., Blondin D.P., Friesen B.J. et al. Seven Days of Cold Acclimation Substantially Reduces Shivering Intensity and Increases Nonshivering Thermogenesis in Adult Humans. Journal Appl. Physiology, 2019, vol. 126 (6), pp. 1598–1606. DOI: 10.1152/japplphysiol.01133
8. Haman F., Souza S.C.S., Castellani J.W. et al. Human Vulnerability and Variability in the Cold: Establishing Individual Risks for Cold Weather Injuries. Temperature (Austin), 2022, vol. 9 (2), pp. 158–195. DOI: 10.1080/23328940.2022.2044740
9. Heinke L., Javanmardi S., Rappelt L. et al. Comparison of the Effects of Cold Water Immersion and Percussive Massage on the Recovery After Exhausting Eccentric Exercise: A Three-armed Randomized Controlled Trial. Front Physiology, 2024, vol. 15, 1432009. DOI: 10.3389/fphys.2024
10. Kelly K.R., Pautz C.M., Palombo L.J. et al. Altered Sympathoadrenal Activity Following Cold-Water Diving. Journal Spec Oper Med., 2023, vol. 23 (3), pp. 74–81. DOI: 10.55460/T5CZ-JXVK
11. Ni W., Stafoggia M., Zhang S. et al. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal American Coll. Cardiology, 2024, vol. 84 (13), pp. 1149–1159. DOI: 10.1016/j.jacc
12. Notley S.R., Mitchell D., Taylor N.A.S. A Century of Exercise Physiology: Concepts That Ignited the Study of Human Thermoregulation. Part 4: Evolution, Thermal Adaptation and Unsupported Theories of Thermoregulation. European Journal Appl Physiology, 2024, vol. 124 (1), pp. 147–218. DOI: 10.1007/s00421-023-05262-9
13. Tabuchi C., Sul H.S. Signaling Pathways Regulating Thermogenesis. Front Endocrinol (Lausanne), 2021, vol. 12, 595020. DOI: 10.3389/fendo.2021.595020
14. Tibenska V., Benesova A., Vebr P. et al. Gradual Cold Acclimation Induces Cardioprotection Without Affecting β-adrenergic Receptor-mediated Adenylyl Cyclase Signaling. Journal Appl. Physiology, 2020, vol. 128 (4), pp. 1023–1032. DOI: 10.1152/japplphysiol.00511.2019
15. Simpson L.L., Hansen A.B., Moralez G. et al. Adrenergic Control of Skeletal Muscle Blood Flow During Chronic Hypoxia in Healthy Males. American Journal Physiology Regulation Integr. Comp. Physiology, 2023, vol. 324 (4), pp. 457–469. DOI: 10.1152/ajpregu.00230.2022
16. Voronkov N.S., Popov S.V., Naryzhnaya N.V. et al. Effect Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury. Iran Biomed Journal, 2024, vol. 28 (2&3), pp. 59–70. DOI: 10.61186/ibj.3872
17. Yurkevicius B.R., Alba B.K., Seeley A.D., Castellani J.W. Human Cold Habituation: Physiology, Timeline, and Modifiers. Temperature (Austin), 2021, vol. 9 (2), pp. 122–157. DOI: 10.1080/23328940.2021.1903145
References
1. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Значение адренорецепторов артерий при симпатолизисе в регуляции кровотока в работающих мышцах // Человек. Спорт. Медицина. 2023. Т. 23, № 2. С. 61–68. [Ananev V.N., Ananev G.V., Ananeva O.V. The Importance of Arterial Adrenoceptors in Sympatholysis in the Regulation of Blood Flow in Working Muscles. Human. Sport. Medicine, 2023, vol. 23 (2), pp. 61–68. (in Russ.)] DOI: 10.14529/hsm2302082. Ананьев В.Н., Ананьев Г.В., Ананьева О.В. Функциональная регуляция адренорецепторов артерий при симпатолизисе в работающих мышцах на норэпинефрин при холодовой адаптации // Человек. Спорт. Медицина. 2024. Т. 24, № 2. С. 33–40. [Ananev V.N., Ananev G.V., Ananeva O.V. Functional Regulation of Artery Adrenoreceptors in Response to Norepi-nephrine Administration During Sympatholysis Following a 30-day Cold Adaptation in Working Muscles. Human. Sport. Medicine, 2024, vol. 24 (2), pp. 33–40. (in Russ.)] DOI: 10.14529/hsm240204
3. DeLorey D.S. Sympathetic Vasoconstriction in Skeletal Muscle: Modulatory Effects of Aging, Exercise Training, and Sex. Appl. Physiology, Nutr. Metabolism, 2021, vol. 46, pp. 1437–1447. DOI: 10.1139/apnm2021-0399
4. DeLorey D.S., Clifford P.S. Does Sympathetic Vasoconstriction Contribute to Metabolism: Perfusion Matching in Exercising Skeletal Muscle? Front Physiology, 2022, vol. 13, 980524. DOI: 10.3389/fphys.2022.980524
5. Eimonte M., Paulauskas H., Daniuseviciute L. et al. Residual Effects of Short-term Whole-body Cold-water Immersion on the Cytokine Profile, White Blood Cell Count, and Blood Markers of Stress. International Journal Hyperthermia, 2021, vol. 38 (1), pp. 696–707. DOI: 10.1080/02656736
6. Elsnicova B., Tibenska V., Galatik F. et al. Continuous Short-term Acclimation to Moderate Cold Elicits Cardioprotection in Rats, and Alters β-adrenergic Signaling and Immune Status. Science Rep., 2023, vol. 13 (1), 18287. DOI: 10.1038/s41598-023-44205-4
7. Gordon K., Blondin D.P., Friesen B.J. et al. Seven Days of Cold Acclimation Substantially Reduces Shivering Intensity and Increases Nonshivering Thermogenesis in Adult Humans. Journal Appl. Physiology, 2019, vol. 126 (6), pp. 1598–1606. DOI: 10.1152/japplphysiol.01133
8. Haman F., Souza S.C.S., Castellani J.W. et al. Human Vulnerability and Variability in the Cold: Establishing Individual Risks for Cold Weather Injuries. Temperature (Austin), 2022, vol. 9 (2), pp. 158–195. DOI: 10.1080/23328940.2022.2044740
9. Heinke L., Javanmardi S., Rappelt L. et al. Comparison of the Effects of Cold Water Immersion and Percussive Massage on the Recovery After Exhausting Eccentric Exercise: A Three-armed Randomized Controlled Trial. Front Physiology, 2024, vol. 15, 1432009. DOI: 10.3389/fphys.2024
10. Kelly K.R., Pautz C.M., Palombo L.J. et al. Altered Sympathoadrenal Activity Following Cold-Water Diving. Journal Spec Oper Med., 2023, vol. 23 (3), pp. 74–81. DOI: 10.55460/T5CZ-JXVK
11. Ni W., Stafoggia M., Zhang S. et al. Short-Term Effects of Lower Air Temperature and Cold Spells on Myocardial Infarction Hospitalizations in Sweden. Journal American Coll. Cardiology, 2024, vol. 84 (13), pp. 1149–1159. DOI: 10.1016/j.jacc
12. Notley S.R., Mitchell D., Taylor N.A.S. A Century of Exercise Physiology: Concepts That Ignited the Study of Human Thermoregulation. Part 4: Evolution, Thermal Adaptation and Unsupported Theories of Thermoregulation. European Journal Appl Physiology, 2024, vol. 124 (1), pp. 147–218. DOI: 10.1007/s00421-023-05262-9
13. Tabuchi C., Sul H.S. Signaling Pathways Regulating Thermogenesis. Front Endocrinol (Lausanne), 2021, vol. 12, 595020. DOI: 10.3389/fendo.2021.595020
14. Tibenska V., Benesova A., Vebr P. et al. Gradual Cold Acclimation Induces Cardioprotection Without Affecting β-adrenergic Receptor-mediated Adenylyl Cyclase Signaling. Journal Appl. Physiology, 2020, vol. 128 (4), pp. 1023–1032. DOI: 10.1152/japplphysiol.00511.2019
15. Simpson L.L., Hansen A.B., Moralez G. et al. Adrenergic Control of Skeletal Muscle Blood Flow During Chronic Hypoxia in Healthy Males. American Journal Physiology Regulation Integr. Comp. Physiology, 2023, vol. 324 (4), pp. 457–469. DOI: 10.1152/ajpregu.00230.2022
16. Voronkov N.S., Popov S.V., Naryzhnaya N.V. et al. Effect Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury. Iran Biomed Journal, 2024, vol. 28 (2&3), pp. 59–70. DOI: 10.61186/ibj.3872
17. Yurkevicius B.R., Alba B.K., Seeley A.D., Castellani J.W. Human Cold Habituation: Physiology, Timeline, and Modifiers. Temperature (Austin), 2021, vol. 9 (2), pp. 122–157. DOI: 10.1080/23328940.2021.1903145
Опубликован
2025-07-04
Как цитировать
Ананьев, В., Ананьев, Г., & Ананьева, О. (2025). ФИЗИОЛОГИЧЕСКИЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ АЛЬФА-1-АДРЕНОРЕЦЕПТОРОВ АРТЕРИЙ К НОРЭПИНЕФРИНУ ПРИ СИМПАТОЛИЗИСЕ НА ФОНЕ 5-ДНЕВНОЙ ХОЛОДОВОЙ АДАПТАЦИИ. Человек. Спорт. Медицина, 25(2), 7-14. https://doi.org/10.14529/hsm250201
Выпуск
Раздел
Физиология
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