ВЛИЯНИЕ УПОТРЕБЛЕНИЯ ЗИЗИФУСА НАСТОЯЩЕГО НА ПРО- И АНТИАПОПТОТИЧЕСКУЮ ЭКСПРЕССИЮ БЕЛКА В НЕЙТРОФИЛАХ ПОСЛЕ СИЛОВЫХ УПРАЖНЕНИЙ
Ключевые слова:
добавка зизифуса, силовые упражнения, апоптоз нейтрофилов, ось [Ca2 ]i-кальпастатин-кальпаин, каспаза-3, Х-связанный ингибитор белка апоптоза
Аннотация
Считается, что зизифус способен оказывать положительное воздействие на иммунные расстройства, вызванные физической нагрузкой, в частности, речь идет о регуляции апоптоза нейтрофилов, однако ее внутриклеточный механизм все еще остается неизученным. Цель. Цель данного исследования – изучить мгновенный эффект от употребления зизифуса настоящего на про- и антиапоптотический уровни белка в нейтрофилах человека в ответ на сеанс круговой тренировки. Материалы и методы. Участники завершили круговую тренировку (75 %, 1ПМ, 9 упражнений, 3 подхода). Пока одна группа получала плацебо, другая группа ежедневно употребляла зизифус (0,5 г/кг веса тела в 2,5 см3 дистиллированной воды) за час до тренировки. Результаты. У участников группы, получавшей плацебо, повысился уровень нейтрофилов [Ca2+]i, кальпаина-1 и каспазы-3 (p < 0,05) при одновременном снижении уровня кальпастатина и Х-связанного ингибитора белка апоптоза (p < 0,05). В свою очередь зизифус либо подавлял [Ca2+]i, либо реверсировал ответы на кальпастатин, кальпаин-1, Х-связанный ингибитор белка апоптоза и каспазу-3 (p < 0,01). Заключение. Данные показывают, что один сеанс интенсивной круговой тренировки индуцировал апоптотическую передачу сигналов в нейтрофилах человека с участием оси [Ca2+]i-кальпастатин-кальпаин, расположенной выше каспазы-3. Однократный прием раствора зизифуса перед тренировкой ослабил эти эффекты, вероятно, за счет обеспечения источников энергии для нейтрофилов или за счет функционирования в качестве антиоксидантов.
Литература
1. Afzalpour M.E., Abtahi Eivari H., Rezazadeh A., Soluki A. Effect of Ziziphus jujuba Supplementation before One Session of Acute Resistance Exercise on the Serum Glutathione Peroxidase and Superoxide Dismutase Activity. Q Horiz Med Sci, 2015, vol. 21 (2), pp. 97–104. DOI: 10.18869/acadpub.hms.21.2.97
2. Afzalpour M.E., Rezazadeh A., Abtahi S.H. Effects of Jujube Fruit on Total Antioxidant Capacity and Lipid Peroxidation in Young Women After an Intensive Resistance Exercise Session. Sport Biomot Sci, 2014, vol. 6 (11), pp. 16–26.
3. Altznauer F., Conus S., Cavalli A. et al. Calpain-1 Regulates Bax and Subsequent Smac-Dependent Caspase-3 Activation in Neutrophil Apoptosis. J Biol Chem, 2004, vol. 279 (7), pp. 5947–5957. DOI: 10.1074/jbc.M308576200
4. Cheng D., Zhu C., Cao J., Jiang W. The Protective Effects of Polyphenols from Jujube Peel (Ziziphus Jujube Mill) on Isoproterenol-Induced Myocardial Ischemia and Aluminum-Induced Oxidative Damage in Rats. Food Chem Toxicol, 2012, vol. 50 (5), pp. 1302–1308. DOI: 10.1016/j.fct.2012.01.026
5. Choi S.H., Ahn J.B., Kozukue N. et al. Distribution of Free Amino Acids, Flavonoids, Total Phenolics, and Antioxidative Activities of Jujube (Ziziphus Jujuba) Fruits and Seeds Harvested from Plants Grown in Korea. J Agric Food Chem, 2011, vol. 59 (12), pp. 6594–6604. DOI: 10.1021/jf200371r
6. Curi T.C., De Melo M.P., De Azeve-do R.B. et al. Glutamine Utilization by Rat Neutrophils: Presence of Phosphate-Dependent Glutaminase. Am J Physiol, 1997, vol. 273 (4 Pt 1), pp. 1124–1129. DOI: 10.1152/ajpcell.1997.273. 4.C1124
7. Cury-Boaventura M.F., Levada-Pires A.C., Folador A. et al. Effects of Exercise on Leukocyte Death: Prevention by Hydrolyzed whey Protein Enriched with Glutamine Dipeptide. Eur J Appl Physiol, 2008, vol. 103 (3), pp. 289–294. DOI: 10.1007/s00421-008-0702-1
8. Gao Q.-H., Wu P.-T., Liu J.-R. et al. Physico-Chemical Properties and Antioxidant Capacity of Different Jujube (Ziziphus jujuba Mill.) Cultivars Grown in Loess Plateau of China. Sci Hortic, 2011, vol. 130 (1), pp. 67–72. DOI: 10.1016/j.scienta.2011.06.005
9. Geering B., Simon H.U. Peculiarities of Сell Death Mechanisms in Neutrophils. Cell Death Differ, 2011, vol. 18 (9), pp. 1457–1469. DOI: 10.1038/cdd.2011.75
10. Ghanbari Niaki A., Mohammadi Joojadeh F., Zare Kookandeh N. et al. Liver and Plasma Nesfatin-1 Responses to 6 Weeks of Treadmill Running with or without Zizyphus Jujuba Liquid Extract in Female Rat. Int J Endocrinol Metab, 2013, vol. 11 (2), pp. 95–101. DOI: 10.5812/ijem.8438
11. Guo S., Duan J.-A., Tang Y. et al. High-Performance Liquid Chromatography – Two Wavelength Detection of Triterpenoid Acids from the Fruits of Ziziphus Jujuba Containing Various Cultivars in Different Regions and Classification Using Chemometric Analysis. J Pharm Biomed Anal, 2009, vol. 49 (5), pp. 1296–1302. DOI: 10.1016/j.jpba.2009.03.006
12. Hamedi S., Arian A.A., Farzaei M.H. Gastroprotective Effect of Aqueous Stem Bark Extract of Ziziphus Jujuba L. Against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. J Tradit Chin Med, 2015, vol. 35 (6), pp. 666–670. DOI: 10.1016/S0254-6272(15)30157-6
13. Huang Y.L., Yen G.C., Sheu F., Chau C.F. Effects of Water-Soluble Carbohydrate Concentrate from Chinese Jujube on Different Intestinal and Fecal Indices. J Agric Food Chem, 2008, vol. 56 (5), pp. 1734–1739. DOI: 10.1021/ jf072664z
14. Kroemer G., Dallaporta B., Resche-Rigon M. The Mitochondrial Death/Life Regulator in Apoptosis and Necrosis. Annu Rev Physiol, 1998, vol. 60, pp. 619–642. DOI: 10.1146/ annurev.physiol.60.1.619
15. Lagranha C.J., deLima T.M., Senna S.M. et al. The Effect of Glutamine Supplementation on the Function of Neutrophils From Exercised Rats. Cell Biochem Funct, 2005, vol. 23 (2), pp. 101–107. DOI: 10.1002/cbf.1192
16. Lagranha C.J., Hirabara S.M., Curi R., Pithon-Curi T.C. Glutamine Supplementation Prevents Exercise-Induced Neutrophil Apoptosis and Reduces p38 MAPK and JNK Phosphorylation and p53 and Caspase 3 Expression. Cell Biochem Funct, 2007, vol. 25 (5), pp. 563–569. DOI: 10.1002/cbf.1421
17. Lagranha C.J., Levada-Pires A.C., Sellitti D.F. et al. The Effect of Glutamine Supplementation and Physical Exercise on Neutrophil Function. Amino Acids, 2008, vol. 34 (3), pp. 337–346. DOI: 10.1007/s00726-007-0560-x
18. Lagranha C.J., Senna S.M., De Lima T.M. et al. Beneficial Effect of Glutamine on Exercise-Induced Apoptosis of Rat Neutrophils. Med Sci Sports Exerc, 2004, vol. 36 (2), pp. 210–217. DOI: 10.1249/01.MSS.0000113490.98089.B1
19. Li J.-W., Fan L.-P., Ding S.-D., Ding X.-L. Nutritional Composition of Five Cultivars of Chinese Jujube. Food Chemistry, 2007, vol. 103 (2), pp. 454–460. DOI: 10.1016/j. foodchem.2006.08.016
20. Li J., Shan L., Liu Y., Fan L., Ai L. Screening of a Functional Polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its Property. Int J Biol Macromol, 2011, vol. 49 (3), pp. 255–259. DOI: 10.1016/j.ijbiomac.2011.04.006
21. Liang S., Juan J. Effect of Jujube Extract on Oxidative Injury in Heart Muscles of Exhausted Training Rats. Afr J Microbiol Res, 2011, vol. 5 (14), pp. 1896–1899. DOI: 10.5897/ AJMR11.447
22. Liu R., Fan W., Kruger K., et al. Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc, 2017, vol. 49 (1), pp. 29–39. DOI: 10.1249/mss.0000000000001080
23. Mooren F.C., Völker K., Klocke R., et al. Exercise Delays Neutrophil Apoptosis by a G-CSF-Dependent Mechanism. J Appl Physiol, 2012, vol. 113 (7), pp. 1082–1090. DOI: 10.1152/japplphysiol.00797.2012
24. Nieper A. Nutritional Supplement Practices in UK Junior National Track and Field Athletes. Br J Sports Med, 2005, vol. 39 (9), pp. 645–649. DOI: 10.1136/bjsm.2004.015842
25. Pawlowska A.M., Camangi F., Bader A., Braca A. Flavonoids of Zizyphus jujuba L. and Zizyphus spina-christi (L.) Willd (Rhamnaceae) fruits. Food Chem, 2009, vol. 112 (4), pp. 858–862. DOI: 10.1016/j.foodchem.2008.06.053
26. Plastina P., Bonofiglio D., Vizza D. et al. Identification of Bioactive Constituents of Ziziphus Jujube Fruit Extracts Exerting Anti-proliferative and Apoptotic Effects in Human Breast Cancer Cells. J Ethnopharmacol, 2012, vol. 140 (2), pp. 325–332. DOI: 10.1016/j.jep.2012.01.022
27. Rodríguez Villanueva J., Rodríguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phyto-therapy Res, 2017, n/a-n/a. DOI: 10.1002/ptr.5759
28. Sabzghabaee A.M., Khayam I., Keli-shadi R. et al. Effect of Zizyphus Jujuba Fruits on Dyslipidemia in Obese Adolescents: a Triple-Masked Randomized Controlled Clinical Trial. Med Arch, 2013, vol. 67 (3), pp. 156–159. DOI: 10.5455/medarh.2013.67.156-160
29. Shen X., Tang Y., Yang R. et al. The Protective Effect of Zizyphus Jujube Fruit on Carbon Tetrachloride-Induced Hepatic Injury in Mice by Anti-Oxidative Activities. J Ethnopharmacol, 2009, vol. 122 (3), pp. 555–560. DOI: 10.1016/j.jep.2009.01.027
30. Striegel H., Simon P., Wurster C. et al. The Use of Nutritional Supplements Among Master Athletes. Int J Sports Med, 2006, vol. 27 (3), pp. 236–241. DOI: 10.1055/s-2005-865648
31. Syu G.D., Chen H.I., Jen C.J. Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox Status. PLoS One, 2011, vol. 6 (9), e24385. DOI: 10.1371/journal.pone.0024385
32. Taati M., Alirezaei M., Meshkatalsadat M.H. et al. Antioxidant Effects of Aqueous Fruit Extract of Ziziphus Jujuba on Ethanol-Induced Oxidative Stress in the Rat Testes. Iran J Vet Res, 2011, vol. 12 (1), pp. 39–45.
33. Tayebi S.M., Saeidi A., Gharahcholo L. et al. Acute and Short-Term Effects of Oral Jujube Solution on White Blood Cell and its Differential count in Response to Circuit Re-sistance Exercise. International Journal of Applied Exercise Physiology, 2016, vol. 5 (2), pp. 1–10.
34. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Acute Effects of Jujube Ziziphus Solution Feeding before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Journal of Applied Exercise Physiology, 2017, vol. 13 (25), pp. 97–114. DOI: 10.22080/jaep.2017.1591
35. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Short-Term Effects of Oral Feeding Jujube Ziziphus Solution before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Ann Appl Sport Sci, 2014, vol. 2 (1), pp. 53–68. DOI: 10.18869/acadpub.aassjournal.2.1.53
36. Tayebi S.M., Saeidi A., Mahmoudi A.A. et al. Acute and Short-Term Effects of Oral Feeding of Jujube Solution on Blood Platelets and its Morphological Indices in Response to a Circuit Resistance Exercise. Annals of Applied Sport Science, 2015, vol. 3 (3), pp. 67–82. DOI: 10.18869/acadpub.aassjournal.3.3.67
37. Vahedi F., Fathi Najafi M., Bozari K. Evaluation of Inhibitory Effect and Apoptosis Induction of Zyzyphus Jujube on Tumor Cell Lines, an in Vitro Preliminary Study. Cytotechnol, 2008, vol. 56 (2), pp. 105–111. DOI: 10.1007/s10616-008-9131-6
38. van Raam B.J., Drewniak A., Groenewold V. et al. Granulocyte Colony-Stimulating Factor Delays Neutrophil Apoptosis by Inhibition of Calpains Upstream of Caspase-3. Blood, 2008, vol. 112 (5), pp. 2046–2054. DOI: 10.1182/blood-2008-04-149575
39. Xue Z., Feng W., Cao J. et al. Antioxidant Activity and Total Phenolic Contents in Peel and Pulp of Chinese Jujube (Ziziphus Jujuba Mill) Fruits. J Food Biochem, 2009, vol. 33 (5), pp. 613–629. DOI: 10.1111/j.1745-4514.2009.00241.x
40. Yoo K.Y., Li H., Hwang I.K. et al. Zizyphus Attenuates Ischemic Damage in the Gerbil Hippocampus via its Antioxidant Effect. J Med Food, 2010, vol. 13 (3), pp. 557–563. DOI: 10.1089/jmf.2009.1254
41. Yu L., Jiang B.P., Luo D. et al. Bioactive Components in the Fruits of Ziziphus Jujuba Mill. Against the Inflammatory Irritant Action of Euphorbia Plants. Phytomed, 2012, vol. 19 (3–4), pp. 239–244. DOI: 10.1016/j. phymed.2011.09.071
2. Afzalpour M.E., Rezazadeh A., Abtahi S.H. Effects of Jujube Fruit on Total Antioxidant Capacity and Lipid Peroxidation in Young Women After an Intensive Resistance Exercise Session. Sport Biomot Sci, 2014, vol. 6 (11), pp. 16–26.
3. Altznauer F., Conus S., Cavalli A. et al. Calpain-1 Regulates Bax and Subsequent Smac-Dependent Caspase-3 Activation in Neutrophil Apoptosis. J Biol Chem, 2004, vol. 279 (7), pp. 5947–5957. DOI: 10.1074/jbc.M308576200
4. Cheng D., Zhu C., Cao J., Jiang W. The Protective Effects of Polyphenols from Jujube Peel (Ziziphus Jujube Mill) on Isoproterenol-Induced Myocardial Ischemia and Aluminum-Induced Oxidative Damage in Rats. Food Chem Toxicol, 2012, vol. 50 (5), pp. 1302–1308. DOI: 10.1016/j.fct.2012.01.026
5. Choi S.H., Ahn J.B., Kozukue N. et al. Distribution of Free Amino Acids, Flavonoids, Total Phenolics, and Antioxidative Activities of Jujube (Ziziphus Jujuba) Fruits and Seeds Harvested from Plants Grown in Korea. J Agric Food Chem, 2011, vol. 59 (12), pp. 6594–6604. DOI: 10.1021/jf200371r
6. Curi T.C., De Melo M.P., De Azeve-do R.B. et al. Glutamine Utilization by Rat Neutrophils: Presence of Phosphate-Dependent Glutaminase. Am J Physiol, 1997, vol. 273 (4 Pt 1), pp. 1124–1129. DOI: 10.1152/ajpcell.1997.273. 4.C1124
7. Cury-Boaventura M.F., Levada-Pires A.C., Folador A. et al. Effects of Exercise on Leukocyte Death: Prevention by Hydrolyzed whey Protein Enriched with Glutamine Dipeptide. Eur J Appl Physiol, 2008, vol. 103 (3), pp. 289–294. DOI: 10.1007/s00421-008-0702-1
8. Gao Q.-H., Wu P.-T., Liu J.-R. et al. Physico-Chemical Properties and Antioxidant Capacity of Different Jujube (Ziziphus jujuba Mill.) Cultivars Grown in Loess Plateau of China. Sci Hortic, 2011, vol. 130 (1), pp. 67–72. DOI: 10.1016/j.scienta.2011.06.005
9. Geering B., Simon H.U. Peculiarities of Сell Death Mechanisms in Neutrophils. Cell Death Differ, 2011, vol. 18 (9), pp. 1457–1469. DOI: 10.1038/cdd.2011.75
10. Ghanbari Niaki A., Mohammadi Joojadeh F., Zare Kookandeh N. et al. Liver and Plasma Nesfatin-1 Responses to 6 Weeks of Treadmill Running with or without Zizyphus Jujuba Liquid Extract in Female Rat. Int J Endocrinol Metab, 2013, vol. 11 (2), pp. 95–101. DOI: 10.5812/ijem.8438
11. Guo S., Duan J.-A., Tang Y. et al. High-Performance Liquid Chromatography – Two Wavelength Detection of Triterpenoid Acids from the Fruits of Ziziphus Jujuba Containing Various Cultivars in Different Regions and Classification Using Chemometric Analysis. J Pharm Biomed Anal, 2009, vol. 49 (5), pp. 1296–1302. DOI: 10.1016/j.jpba.2009.03.006
12. Hamedi S., Arian A.A., Farzaei M.H. Gastroprotective Effect of Aqueous Stem Bark Extract of Ziziphus Jujuba L. Against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. J Tradit Chin Med, 2015, vol. 35 (6), pp. 666–670. DOI: 10.1016/S0254-6272(15)30157-6
13. Huang Y.L., Yen G.C., Sheu F., Chau C.F. Effects of Water-Soluble Carbohydrate Concentrate from Chinese Jujube on Different Intestinal and Fecal Indices. J Agric Food Chem, 2008, vol. 56 (5), pp. 1734–1739. DOI: 10.1021/ jf072664z
14. Kroemer G., Dallaporta B., Resche-Rigon M. The Mitochondrial Death/Life Regulator in Apoptosis and Necrosis. Annu Rev Physiol, 1998, vol. 60, pp. 619–642. DOI: 10.1146/ annurev.physiol.60.1.619
15. Lagranha C.J., deLima T.M., Senna S.M. et al. The Effect of Glutamine Supplementation on the Function of Neutrophils From Exercised Rats. Cell Biochem Funct, 2005, vol. 23 (2), pp. 101–107. DOI: 10.1002/cbf.1192
16. Lagranha C.J., Hirabara S.M., Curi R., Pithon-Curi T.C. Glutamine Supplementation Prevents Exercise-Induced Neutrophil Apoptosis and Reduces p38 MAPK and JNK Phosphorylation and p53 and Caspase 3 Expression. Cell Biochem Funct, 2007, vol. 25 (5), pp. 563–569. DOI: 10.1002/cbf.1421
17. Lagranha C.J., Levada-Pires A.C., Sellitti D.F. et al. The Effect of Glutamine Supplementation and Physical Exercise on Neutrophil Function. Amino Acids, 2008, vol. 34 (3), pp. 337–346. DOI: 10.1007/s00726-007-0560-x
18. Lagranha C.J., Senna S.M., De Lima T.M. et al. Beneficial Effect of Glutamine on Exercise-Induced Apoptosis of Rat Neutrophils. Med Sci Sports Exerc, 2004, vol. 36 (2), pp. 210–217. DOI: 10.1249/01.MSS.0000113490.98089.B1
19. Li J.-W., Fan L.-P., Ding S.-D., Ding X.-L. Nutritional Composition of Five Cultivars of Chinese Jujube. Food Chemistry, 2007, vol. 103 (2), pp. 454–460. DOI: 10.1016/j. foodchem.2006.08.016
20. Li J., Shan L., Liu Y., Fan L., Ai L. Screening of a Functional Polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its Property. Int J Biol Macromol, 2011, vol. 49 (3), pp. 255–259. DOI: 10.1016/j.ijbiomac.2011.04.006
21. Liang S., Juan J. Effect of Jujube Extract on Oxidative Injury in Heart Muscles of Exhausted Training Rats. Afr J Microbiol Res, 2011, vol. 5 (14), pp. 1896–1899. DOI: 10.5897/ AJMR11.447
22. Liu R., Fan W., Kruger K., et al. Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc, 2017, vol. 49 (1), pp. 29–39. DOI: 10.1249/mss.0000000000001080
23. Mooren F.C., Völker K., Klocke R., et al. Exercise Delays Neutrophil Apoptosis by a G-CSF-Dependent Mechanism. J Appl Physiol, 2012, vol. 113 (7), pp. 1082–1090. DOI: 10.1152/japplphysiol.00797.2012
24. Nieper A. Nutritional Supplement Practices in UK Junior National Track and Field Athletes. Br J Sports Med, 2005, vol. 39 (9), pp. 645–649. DOI: 10.1136/bjsm.2004.015842
25. Pawlowska A.M., Camangi F., Bader A., Braca A. Flavonoids of Zizyphus jujuba L. and Zizyphus spina-christi (L.) Willd (Rhamnaceae) fruits. Food Chem, 2009, vol. 112 (4), pp. 858–862. DOI: 10.1016/j.foodchem.2008.06.053
26. Plastina P., Bonofiglio D., Vizza D. et al. Identification of Bioactive Constituents of Ziziphus Jujube Fruit Extracts Exerting Anti-proliferative and Apoptotic Effects in Human Breast Cancer Cells. J Ethnopharmacol, 2012, vol. 140 (2), pp. 325–332. DOI: 10.1016/j.jep.2012.01.022
27. Rodríguez Villanueva J., Rodríguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phyto-therapy Res, 2017, n/a-n/a. DOI: 10.1002/ptr.5759
28. Sabzghabaee A.M., Khayam I., Keli-shadi R. et al. Effect of Zizyphus Jujuba Fruits on Dyslipidemia in Obese Adolescents: a Triple-Masked Randomized Controlled Clinical Trial. Med Arch, 2013, vol. 67 (3), pp. 156–159. DOI: 10.5455/medarh.2013.67.156-160
29. Shen X., Tang Y., Yang R. et al. The Protective Effect of Zizyphus Jujube Fruit on Carbon Tetrachloride-Induced Hepatic Injury in Mice by Anti-Oxidative Activities. J Ethnopharmacol, 2009, vol. 122 (3), pp. 555–560. DOI: 10.1016/j.jep.2009.01.027
30. Striegel H., Simon P., Wurster C. et al. The Use of Nutritional Supplements Among Master Athletes. Int J Sports Med, 2006, vol. 27 (3), pp. 236–241. DOI: 10.1055/s-2005-865648
31. Syu G.D., Chen H.I., Jen C.J. Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox Status. PLoS One, 2011, vol. 6 (9), e24385. DOI: 10.1371/journal.pone.0024385
32. Taati M., Alirezaei M., Meshkatalsadat M.H. et al. Antioxidant Effects of Aqueous Fruit Extract of Ziziphus Jujuba on Ethanol-Induced Oxidative Stress in the Rat Testes. Iran J Vet Res, 2011, vol. 12 (1), pp. 39–45.
33. Tayebi S.M., Saeidi A., Gharahcholo L. et al. Acute and Short-Term Effects of Oral Jujube Solution on White Blood Cell and its Differential count in Response to Circuit Re-sistance Exercise. International Journal of Applied Exercise Physiology, 2016, vol. 5 (2), pp. 1–10.
34. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Acute Effects of Jujube Ziziphus Solution Feeding before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Journal of Applied Exercise Physiology, 2017, vol. 13 (25), pp. 97–114. DOI: 10.22080/jaep.2017.1591
35. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Short-Term Effects of Oral Feeding Jujube Ziziphus Solution before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Ann Appl Sport Sci, 2014, vol. 2 (1), pp. 53–68. DOI: 10.18869/acadpub.aassjournal.2.1.53
36. Tayebi S.M., Saeidi A., Mahmoudi A.A. et al. Acute and Short-Term Effects of Oral Feeding of Jujube Solution on Blood Platelets and its Morphological Indices in Response to a Circuit Resistance Exercise. Annals of Applied Sport Science, 2015, vol. 3 (3), pp. 67–82. DOI: 10.18869/acadpub.aassjournal.3.3.67
37. Vahedi F., Fathi Najafi M., Bozari K. Evaluation of Inhibitory Effect and Apoptosis Induction of Zyzyphus Jujube on Tumor Cell Lines, an in Vitro Preliminary Study. Cytotechnol, 2008, vol. 56 (2), pp. 105–111. DOI: 10.1007/s10616-008-9131-6
38. van Raam B.J., Drewniak A., Groenewold V. et al. Granulocyte Colony-Stimulating Factor Delays Neutrophil Apoptosis by Inhibition of Calpains Upstream of Caspase-3. Blood, 2008, vol. 112 (5), pp. 2046–2054. DOI: 10.1182/blood-2008-04-149575
39. Xue Z., Feng W., Cao J. et al. Antioxidant Activity and Total Phenolic Contents in Peel and Pulp of Chinese Jujube (Ziziphus Jujuba Mill) Fruits. J Food Biochem, 2009, vol. 33 (5), pp. 613–629. DOI: 10.1111/j.1745-4514.2009.00241.x
40. Yoo K.Y., Li H., Hwang I.K. et al. Zizyphus Attenuates Ischemic Damage in the Gerbil Hippocampus via its Antioxidant Effect. J Med Food, 2010, vol. 13 (3), pp. 557–563. DOI: 10.1089/jmf.2009.1254
41. Yu L., Jiang B.P., Luo D. et al. Bioactive Components in the Fruits of Ziziphus Jujuba Mill. Against the Inflammatory Irritant Action of Euphorbia Plants. Phytomed, 2012, vol. 19 (3–4), pp. 239–244. DOI: 10.1016/j. phymed.2011.09.071
2. Afzalpour M.E., Rezazadeh A., Abtahi S.H. Effects of Jujube Fruit on Total Antioxidant Capacity and Lipid Peroxidation in Young Women After an Intensive Resistance Exercise Session. Sport Biomot Sci, 2014, vol. 6 (11), pp. 16–26.
3. Altznauer F., Conus S., Cavalli A. et al. Calpain-1 Regulates Bax and Subsequent Smac-Dependent Caspase-3 Activation in Neutrophil Apoptosis. J Biol Chem, 2004, vol. 279 (7), pp. 5947–5957. DOI: 10.1074/jbc.M308576200
4. Cheng D., Zhu C., Cao J., Jiang W. The Protective Effects of Polyphenols from Jujube Peel (Ziziphus Jujube Mill) on Isoproterenol-Induced Myocardial Ischemia and Aluminum-Induced Oxidative Damage in Rats. Food Chem Toxicol, 2012, vol. 50 (5), pp. 1302–1308. DOI: 10.1016/j.fct.2012.01.026
5. Choi S.H., Ahn J.B., Kozukue N. et al. Distribution of Free Amino Acids, Flavonoids, Total Phenolics, and Antioxidative Activities of Jujube (Ziziphus Jujuba) Fruits and Seeds Harvested from Plants Grown in Korea. J Agric Food Chem, 2011, vol. 59 (12), pp. 6594–6604. DOI: 10.1021/jf200371r
6. Curi T.C., De Melo M.P., De Azeve-do R.B. et al. Glutamine Utilization by Rat Neutrophils: Presence of Phosphate-Dependent Glutaminase. Am J Physiol, 1997, vol. 273 (4 Pt 1), pp. 1124–1129. DOI: 10.1152/ajpcell.1997.273. 4.C1124
7. Cury-Boaventura M.F., Levada-Pires A.C., Folador A. et al. Effects of Exercise on Leukocyte Death: Prevention by Hydrolyzed whey Protein Enriched with Glutamine Dipeptide. Eur J Appl Physiol, 2008, vol. 103 (3), pp. 289–294. DOI: 10.1007/s00421-008-0702-1
8. Gao Q.-H., Wu P.-T., Liu J.-R. et al. Physico-Chemical Properties and Antioxidant Capacity of Different Jujube (Ziziphus jujuba Mill.) Cultivars Grown in Loess Plateau of China. Sci Hortic, 2011, vol. 130 (1), pp. 67–72. DOI: 10.1016/j.scienta.2011.06.005
9. Geering B., Simon H.U. Peculiarities of Сell Death Mechanisms in Neutrophils. Cell Death Differ, 2011, vol. 18 (9), pp. 1457–1469. DOI: 10.1038/cdd.2011.75
10. Ghanbari Niaki A., Mohammadi Joojadeh F., Zare Kookandeh N. et al. Liver and Plasma Nesfatin-1 Responses to 6 Weeks of Treadmill Running with or without Zizyphus Jujuba Liquid Extract in Female Rat. Int J Endocrinol Metab, 2013, vol. 11 (2), pp. 95–101. DOI: 10.5812/ijem.8438
11. Guo S., Duan J.-A., Tang Y. et al. High-Performance Liquid Chromatography – Two Wavelength Detection of Triterpenoid Acids from the Fruits of Ziziphus Jujuba Containing Various Cultivars in Different Regions and Classification Using Chemometric Analysis. J Pharm Biomed Anal, 2009, vol. 49 (5), pp. 1296–1302. DOI: 10.1016/j.jpba.2009.03.006
12. Hamedi S., Arian A.A., Farzaei M.H. Gastroprotective Effect of Aqueous Stem Bark Extract of Ziziphus Jujuba L. Against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. J Tradit Chin Med, 2015, vol. 35 (6), pp. 666–670. DOI: 10.1016/S0254-6272(15)30157-6
13. Huang Y.L., Yen G.C., Sheu F., Chau C.F. Effects of Water-Soluble Carbohydrate Concentrate from Chinese Jujube on Different Intestinal and Fecal Indices. J Agric Food Chem, 2008, vol. 56 (5), pp. 1734–1739. DOI: 10.1021/ jf072664z
14. Kroemer G., Dallaporta B., Resche-Rigon M. The Mitochondrial Death/Life Regulator in Apoptosis and Necrosis. Annu Rev Physiol, 1998, vol. 60, pp. 619–642. DOI: 10.1146/ annurev.physiol.60.1.619
15. Lagranha C.J., deLima T.M., Senna S.M. et al. The Effect of Glutamine Supplementation on the Function of Neutrophils From Exercised Rats. Cell Biochem Funct, 2005, vol. 23 (2), pp. 101–107. DOI: 10.1002/cbf.1192
16. Lagranha C.J., Hirabara S.M., Curi R., Pithon-Curi T.C. Glutamine Supplementation Prevents Exercise-Induced Neutrophil Apoptosis and Reduces p38 MAPK and JNK Phosphorylation and p53 and Caspase 3 Expression. Cell Biochem Funct, 2007, vol. 25 (5), pp. 563–569. DOI: 10.1002/cbf.1421
17. Lagranha C.J., Levada-Pires A.C., Sellitti D.F. et al. The Effect of Glutamine Supplementation and Physical Exercise on Neutrophil Function. Amino Acids, 2008, vol. 34 (3), pp. 337–346. DOI: 10.1007/s00726-007-0560-x
18. Lagranha C.J., Senna S.M., De Lima T.M. et al. Beneficial Effect of Glutamine on Exercise-Induced Apoptosis of Rat Neutrophils. Med Sci Sports Exerc, 2004, vol. 36 (2), pp. 210–217. DOI: 10.1249/01.MSS.0000113490.98089.B1
19. Li J.-W., Fan L.-P., Ding S.-D., Ding X.-L. Nutritional Composition of Five Cultivars of Chinese Jujube. Food Chemistry, 2007, vol. 103 (2), pp. 454–460. DOI: 10.1016/j. foodchem.2006.08.016
20. Li J., Shan L., Liu Y., Fan L., Ai L. Screening of a Functional Polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its Property. Int J Biol Macromol, 2011, vol. 49 (3), pp. 255–259. DOI: 10.1016/j.ijbiomac.2011.04.006
21. Liang S., Juan J. Effect of Jujube Extract on Oxidative Injury in Heart Muscles of Exhausted Training Rats. Afr J Microbiol Res, 2011, vol. 5 (14), pp. 1896–1899. DOI: 10.5897/ AJMR11.447
22. Liu R., Fan W., Kruger K., et al. Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc, 2017, vol. 49 (1), pp. 29–39. DOI: 10.1249/mss.0000000000001080
23. Mooren F.C., Völker K., Klocke R., et al. Exercise Delays Neutrophil Apoptosis by a G-CSF-Dependent Mechanism. J Appl Physiol, 2012, vol. 113 (7), pp. 1082–1090. DOI: 10.1152/japplphysiol.00797.2012
24. Nieper A. Nutritional Supplement Practices in UK Junior National Track and Field Athletes. Br J Sports Med, 2005, vol. 39 (9), pp. 645–649. DOI: 10.1136/bjsm.2004.015842
25. Pawlowska A.M., Camangi F., Bader A., Braca A. Flavonoids of Zizyphus jujuba L. and Zizyphus spina-christi (L.) Willd (Rhamnaceae) fruits. Food Chem, 2009, vol. 112 (4), pp. 858–862. DOI: 10.1016/j.foodchem.2008.06.053
26. Plastina P., Bonofiglio D., Vizza D. et al. Identification of Bioactive Constituents of Ziziphus Jujube Fruit Extracts Exerting Anti-proliferative and Apoptotic Effects in Human Breast Cancer Cells. J Ethnopharmacol, 2012, vol. 140 (2), pp. 325–332. DOI: 10.1016/j.jep.2012.01.022
27. Rodríguez Villanueva J., Rodríguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phyto-therapy Res, 2017, n/a-n/a. DOI: 10.1002/ptr.5759
28. Sabzghabaee A.M., Khayam I., Keli-shadi R. et al. Effect of Zizyphus Jujuba Fruits on Dyslipidemia in Obese Adolescents: a Triple-Masked Randomized Controlled Clinical Trial. Med Arch, 2013, vol. 67 (3), pp. 156–159. DOI: 10.5455/medarh.2013.67.156-160
29. Shen X., Tang Y., Yang R. et al. The Protective Effect of Zizyphus Jujube Fruit on Carbon Tetrachloride-Induced Hepatic Injury in Mice by Anti-Oxidative Activities. J Ethnopharmacol, 2009, vol. 122 (3), pp. 555–560. DOI: 10.1016/j.jep.2009.01.027
30. Striegel H., Simon P., Wurster C. et al. The Use of Nutritional Supplements Among Master Athletes. Int J Sports Med, 2006, vol. 27 (3), pp. 236–241. DOI: 10.1055/s-2005-865648
31. Syu G.D., Chen H.I., Jen C.J. Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox Status. PLoS One, 2011, vol. 6 (9), e24385. DOI: 10.1371/journal.pone.0024385
32. Taati M., Alirezaei M., Meshkatalsadat M.H. et al. Antioxidant Effects of Aqueous Fruit Extract of Ziziphus Jujuba on Ethanol-Induced Oxidative Stress in the Rat Testes. Iran J Vet Res, 2011, vol. 12 (1), pp. 39–45.
33. Tayebi S.M., Saeidi A., Gharahcholo L. et al. Acute and Short-Term Effects of Oral Jujube Solution on White Blood Cell and its Differential count in Response to Circuit Re-sistance Exercise. International Journal of Applied Exercise Physiology, 2016, vol. 5 (2), pp. 1–10.
34. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Acute Effects of Jujube Ziziphus Solution Feeding before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Journal of Applied Exercise Physiology, 2017, vol. 13 (25), pp. 97–114. DOI: 10.22080/jaep.2017.1591
35. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Short-Term Effects of Oral Feeding Jujube Ziziphus Solution before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Ann Appl Sport Sci, 2014, vol. 2 (1), pp. 53–68. DOI: 10.18869/acadpub.aassjournal.2.1.53
36. Tayebi S.M., Saeidi A., Mahmoudi A.A. et al. Acute and Short-Term Effects of Oral Feeding of Jujube Solution on Blood Platelets and its Morphological Indices in Response to a Circuit Resistance Exercise. Annals of Applied Sport Science, 2015, vol. 3 (3), pp. 67–82. DOI: 10.18869/acadpub.aassjournal.3.3.67
37. Vahedi F., Fathi Najafi M., Bozari K. Evaluation of Inhibitory Effect and Apoptosis Induction of Zyzyphus Jujube on Tumor Cell Lines, an in Vitro Preliminary Study. Cytotechnol, 2008, vol. 56 (2), pp. 105–111. DOI: 10.1007/s10616-008-9131-6
38. van Raam B.J., Drewniak A., Groenewold V. et al. Granulocyte Colony-Stimulating Factor Delays Neutrophil Apoptosis by Inhibition of Calpains Upstream of Caspase-3. Blood, 2008, vol. 112 (5), pp. 2046–2054. DOI: 10.1182/blood-2008-04-149575
39. Xue Z., Feng W., Cao J. et al. Antioxidant Activity and Total Phenolic Contents in Peel and Pulp of Chinese Jujube (Ziziphus Jujuba Mill) Fruits. J Food Biochem, 2009, vol. 33 (5), pp. 613–629. DOI: 10.1111/j.1745-4514.2009.00241.x
40. Yoo K.Y., Li H., Hwang I.K. et al. Zizyphus Attenuates Ischemic Damage in the Gerbil Hippocampus via its Antioxidant Effect. J Med Food, 2010, vol. 13 (3), pp. 557–563. DOI: 10.1089/jmf.2009.1254
41. Yu L., Jiang B.P., Luo D. et al. Bioactive Components in the Fruits of Ziziphus Jujuba Mill. Against the Inflammatory Irritant Action of Euphorbia Plants. Phytomed, 2012, vol. 19 (3–4), pp. 239–244. DOI: 10.1016/j. phymed.2011.09.071
References
1. Afzalpour M.E., Abtahi Eivari H., Rezazadeh A., Soluki A. Effect of Ziziphus jujuba Supplementation before One Session of Acute Resistance Exercise on the Serum Glutathione Peroxidase and Superoxide Dismutase Activity. Q Horiz Med Sci, 2015, vol. 21 (2), pp. 97–104. DOI: 10.18869/acadpub.hms.21.2.972. Afzalpour M.E., Rezazadeh A., Abtahi S.H. Effects of Jujube Fruit on Total Antioxidant Capacity and Lipid Peroxidation in Young Women After an Intensive Resistance Exercise Session. Sport Biomot Sci, 2014, vol. 6 (11), pp. 16–26.
3. Altznauer F., Conus S., Cavalli A. et al. Calpain-1 Regulates Bax and Subsequent Smac-Dependent Caspase-3 Activation in Neutrophil Apoptosis. J Biol Chem, 2004, vol. 279 (7), pp. 5947–5957. DOI: 10.1074/jbc.M308576200
4. Cheng D., Zhu C., Cao J., Jiang W. The Protective Effects of Polyphenols from Jujube Peel (Ziziphus Jujube Mill) on Isoproterenol-Induced Myocardial Ischemia and Aluminum-Induced Oxidative Damage in Rats. Food Chem Toxicol, 2012, vol. 50 (5), pp. 1302–1308. DOI: 10.1016/j.fct.2012.01.026
5. Choi S.H., Ahn J.B., Kozukue N. et al. Distribution of Free Amino Acids, Flavonoids, Total Phenolics, and Antioxidative Activities of Jujube (Ziziphus Jujuba) Fruits and Seeds Harvested from Plants Grown in Korea. J Agric Food Chem, 2011, vol. 59 (12), pp. 6594–6604. DOI: 10.1021/jf200371r
6. Curi T.C., De Melo M.P., De Azeve-do R.B. et al. Glutamine Utilization by Rat Neutrophils: Presence of Phosphate-Dependent Glutaminase. Am J Physiol, 1997, vol. 273 (4 Pt 1), pp. 1124–1129. DOI: 10.1152/ajpcell.1997.273. 4.C1124
7. Cury-Boaventura M.F., Levada-Pires A.C., Folador A. et al. Effects of Exercise on Leukocyte Death: Prevention by Hydrolyzed whey Protein Enriched with Glutamine Dipeptide. Eur J Appl Physiol, 2008, vol. 103 (3), pp. 289–294. DOI: 10.1007/s00421-008-0702-1
8. Gao Q.-H., Wu P.-T., Liu J.-R. et al. Physico-Chemical Properties and Antioxidant Capacity of Different Jujube (Ziziphus jujuba Mill.) Cultivars Grown in Loess Plateau of China. Sci Hortic, 2011, vol. 130 (1), pp. 67–72. DOI: 10.1016/j.scienta.2011.06.005
9. Geering B., Simon H.U. Peculiarities of Сell Death Mechanisms in Neutrophils. Cell Death Differ, 2011, vol. 18 (9), pp. 1457–1469. DOI: 10.1038/cdd.2011.75
10. Ghanbari Niaki A., Mohammadi Joojadeh F., Zare Kookandeh N. et al. Liver and Plasma Nesfatin-1 Responses to 6 Weeks of Treadmill Running with or without Zizyphus Jujuba Liquid Extract in Female Rat. Int J Endocrinol Metab, 2013, vol. 11 (2), pp. 95–101. DOI: 10.5812/ijem.8438
11. Guo S., Duan J.-A., Tang Y. et al. High-Performance Liquid Chromatography – Two Wavelength Detection of Triterpenoid Acids from the Fruits of Ziziphus Jujuba Containing Various Cultivars in Different Regions and Classification Using Chemometric Analysis. J Pharm Biomed Anal, 2009, vol. 49 (5), pp. 1296–1302. DOI: 10.1016/j.jpba.2009.03.006
12. Hamedi S., Arian A.A., Farzaei M.H. Gastroprotective Effect of Aqueous Stem Bark Extract of Ziziphus Jujuba L. Against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats. J Tradit Chin Med, 2015, vol. 35 (6), pp. 666–670. DOI: 10.1016/S0254-6272(15)30157-6
13. Huang Y.L., Yen G.C., Sheu F., Chau C.F. Effects of Water-Soluble Carbohydrate Concentrate from Chinese Jujube on Different Intestinal and Fecal Indices. J Agric Food Chem, 2008, vol. 56 (5), pp. 1734–1739. DOI: 10.1021/ jf072664z
14. Kroemer G., Dallaporta B., Resche-Rigon M. The Mitochondrial Death/Life Regulator in Apoptosis and Necrosis. Annu Rev Physiol, 1998, vol. 60, pp. 619–642. DOI: 10.1146/ annurev.physiol.60.1.619
15. Lagranha C.J., deLima T.M., Senna S.M. et al. The Effect of Glutamine Supplementation on the Function of Neutrophils From Exercised Rats. Cell Biochem Funct, 2005, vol. 23 (2), pp. 101–107. DOI: 10.1002/cbf.1192
16. Lagranha C.J., Hirabara S.M., Curi R., Pithon-Curi T.C. Glutamine Supplementation Prevents Exercise-Induced Neutrophil Apoptosis and Reduces p38 MAPK and JNK Phosphorylation and p53 and Caspase 3 Expression. Cell Biochem Funct, 2007, vol. 25 (5), pp. 563–569. DOI: 10.1002/cbf.1421
17. Lagranha C.J., Levada-Pires A.C., Sellitti D.F. et al. The Effect of Glutamine Supplementation and Physical Exercise on Neutrophil Function. Amino Acids, 2008, vol. 34 (3), pp. 337–346. DOI: 10.1007/s00726-007-0560-x
18. Lagranha C.J., Senna S.M., De Lima T.M. et al. Beneficial Effect of Glutamine on Exercise-Induced Apoptosis of Rat Neutrophils. Med Sci Sports Exerc, 2004, vol. 36 (2), pp. 210–217. DOI: 10.1249/01.MSS.0000113490.98089.B1
19. Li J.-W., Fan L.-P., Ding S.-D., Ding X.-L. Nutritional Composition of Five Cultivars of Chinese Jujube. Food Chemistry, 2007, vol. 103 (2), pp. 454–460. DOI: 10.1016/j. foodchem.2006.08.016
20. Li J., Shan L., Liu Y., Fan L., Ai L. Screening of a Functional Polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its Property. Int J Biol Macromol, 2011, vol. 49 (3), pp. 255–259. DOI: 10.1016/j.ijbiomac.2011.04.006
21. Liang S., Juan J. Effect of Jujube Extract on Oxidative Injury in Heart Muscles of Exhausted Training Rats. Afr J Microbiol Res, 2011, vol. 5 (14), pp. 1896–1899. DOI: 10.5897/ AJMR11.447
22. Liu R., Fan W., Kruger K., et al. Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis. Med Sci Sports Exerc, 2017, vol. 49 (1), pp. 29–39. DOI: 10.1249/mss.0000000000001080
23. Mooren F.C., Völker K., Klocke R., et al. Exercise Delays Neutrophil Apoptosis by a G-CSF-Dependent Mechanism. J Appl Physiol, 2012, vol. 113 (7), pp. 1082–1090. DOI: 10.1152/japplphysiol.00797.2012
24. Nieper A. Nutritional Supplement Practices in UK Junior National Track and Field Athletes. Br J Sports Med, 2005, vol. 39 (9), pp. 645–649. DOI: 10.1136/bjsm.2004.015842
25. Pawlowska A.M., Camangi F., Bader A., Braca A. Flavonoids of Zizyphus jujuba L. and Zizyphus spina-christi (L.) Willd (Rhamnaceae) fruits. Food Chem, 2009, vol. 112 (4), pp. 858–862. DOI: 10.1016/j.foodchem.2008.06.053
26. Plastina P., Bonofiglio D., Vizza D. et al. Identification of Bioactive Constituents of Ziziphus Jujube Fruit Extracts Exerting Anti-proliferative and Apoptotic Effects in Human Breast Cancer Cells. J Ethnopharmacol, 2012, vol. 140 (2), pp. 325–332. DOI: 10.1016/j.jep.2012.01.022
27. Rodríguez Villanueva J., Rodríguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phyto-therapy Res, 2017, n/a-n/a. DOI: 10.1002/ptr.5759
28. Sabzghabaee A.M., Khayam I., Keli-shadi R. et al. Effect of Zizyphus Jujuba Fruits on Dyslipidemia in Obese Adolescents: a Triple-Masked Randomized Controlled Clinical Trial. Med Arch, 2013, vol. 67 (3), pp. 156–159. DOI: 10.5455/medarh.2013.67.156-160
29. Shen X., Tang Y., Yang R. et al. The Protective Effect of Zizyphus Jujube Fruit on Carbon Tetrachloride-Induced Hepatic Injury in Mice by Anti-Oxidative Activities. J Ethnopharmacol, 2009, vol. 122 (3), pp. 555–560. DOI: 10.1016/j.jep.2009.01.027
30. Striegel H., Simon P., Wurster C. et al. The Use of Nutritional Supplements Among Master Athletes. Int J Sports Med, 2006, vol. 27 (3), pp. 236–241. DOI: 10.1055/s-2005-865648
31. Syu G.D., Chen H.I., Jen C.J. Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox Status. PLoS One, 2011, vol. 6 (9), e24385. DOI: 10.1371/journal.pone.0024385
32. Taati M., Alirezaei M., Meshkatalsadat M.H. et al. Antioxidant Effects of Aqueous Fruit Extract of Ziziphus Jujuba on Ethanol-Induced Oxidative Stress in the Rat Testes. Iran J Vet Res, 2011, vol. 12 (1), pp. 39–45.
33. Tayebi S.M., Saeidi A., Gharahcholo L. et al. Acute and Short-Term Effects of Oral Jujube Solution on White Blood Cell and its Differential count in Response to Circuit Re-sistance Exercise. International Journal of Applied Exercise Physiology, 2016, vol. 5 (2), pp. 1–10.
34. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Acute Effects of Jujube Ziziphus Solution Feeding before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Journal of Applied Exercise Physiology, 2017, vol. 13 (25), pp. 97–114. DOI: 10.22080/jaep.2017.1591
35. Tayebi S.M., Agha-Alinejad H., Shafaee S. et al. Short-Term Effects of Oral Feeding Jujube Ziziphus Solution before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil. Ann Appl Sport Sci, 2014, vol. 2 (1), pp. 53–68. DOI: 10.18869/acadpub.aassjournal.2.1.53
36. Tayebi S.M., Saeidi A., Mahmoudi A.A. et al. Acute and Short-Term Effects of Oral Feeding of Jujube Solution on Blood Platelets and its Morphological Indices in Response to a Circuit Resistance Exercise. Annals of Applied Sport Science, 2015, vol. 3 (3), pp. 67–82. DOI: 10.18869/acadpub.aassjournal.3.3.67
37. Vahedi F., Fathi Najafi M., Bozari K. Evaluation of Inhibitory Effect and Apoptosis Induction of Zyzyphus Jujube on Tumor Cell Lines, an in Vitro Preliminary Study. Cytotechnol, 2008, vol. 56 (2), pp. 105–111. DOI: 10.1007/s10616-008-9131-6
38. van Raam B.J., Drewniak A., Groenewold V. et al. Granulocyte Colony-Stimulating Factor Delays Neutrophil Apoptosis by Inhibition of Calpains Upstream of Caspase-3. Blood, 2008, vol. 112 (5), pp. 2046–2054. DOI: 10.1182/blood-2008-04-149575
39. Xue Z., Feng W., Cao J. et al. Antioxidant Activity and Total Phenolic Contents in Peel and Pulp of Chinese Jujube (Ziziphus Jujuba Mill) Fruits. J Food Biochem, 2009, vol. 33 (5), pp. 613–629. DOI: 10.1111/j.1745-4514.2009.00241.x
40. Yoo K.Y., Li H., Hwang I.K. et al. Zizyphus Attenuates Ischemic Damage in the Gerbil Hippocampus via its Antioxidant Effect. J Med Food, 2010, vol. 13 (3), pp. 557–563. DOI: 10.1089/jmf.2009.1254
41. Yu L., Jiang B.P., Luo D. et al. Bioactive Components in the Fruits of Ziziphus Jujuba Mill. Against the Inflammatory Irritant Action of Euphorbia Plants. Phytomed, 2012, vol. 19 (3–4), pp. 239–244. DOI: 10.1016/j. phymed.2011.09.071
Опубликован
2020-11-05
Как цитировать
Тайеби, С., Крюгер, К., Сафакар, М., Бахрами, П., Тахмасб, Г., & Ненашева, А. (2020). ВЛИЯНИЕ УПОТРЕБЛЕНИЯ ЗИЗИФУСА НАСТОЯЩЕГО НА ПРО- И АНТИАПОПТОТИЧЕСКУЮ ЭКСПРЕССИЮ БЕЛКА В НЕЙТРОФИЛАХ ПОСЛЕ СИЛОВЫХ УПРАЖНЕНИЙ. Человек. Спорт. Медицина, 20(3), 5-14. https://doi.org/10.14529/hsm200301
Выпуск
Раздел
Физиология
Copyright (c) 2020 Человек. Спорт. Медицина
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.
