ВЛИЯНИЕ ПРИМЕНЕНИЯ ГИДРОЛИЗАТА КОЛЛАГЕНА В КОМБИНАЦИИ С ЭЛАСТИНОМ НА ФУНКЦИОНАЛЬНУЮ СТАБИЛЬНОСТЬ СУСТАВА СРЕДИ СПОРТСМЕНОВ С ХРОНИЧЕСКОЙ НЕСТАБИЛЬНОСТЬЮ ГОЛЕНОСТОПНОГО СУСТАВА
Ключевые слова:
коллаген, гидролизат коллагена, нестабильность голеностопного сустава, CAIT, Y-balance test
Аннотация
Цель: в рамках проспективного рандомизированного плацебо-контролируемого клинического исследования оценить последствия парентерального приема гидролизата коллагена в комбинации с эластином на функциональные параметры сустава среди спортсменов с хронической нестабильностью голеностопного сустава. Материалы и методы. В исследовании приняли участие 40 (100 %) действующих спортсменов-разрядников, представляющих командные виды спорта. Основную группу составили 20 (50,0 %) участников, которым было предложено использовать в качестве пищевой добавки гидролизат коллагена пищевого в комбинации с эластином под брендом «ПЕРВЫЙ ЖИВОЙ КОЛЛАГЕН» в дозе 10,0 г/сут на протяжении 90 дней, и группа-плацебо, состоящая из 20 (50,0 %) участников, принимающих мальтодекстрин в дозе 10,0 г/сут в течение 90 дней. Оценку функциональной нестабильности оценивали с помощью теста CAIT, теста на равновесие и стабильность Y-balance test, субъективную оценку интенсивности болевого синдрома приводили с помощью шкалы ВАШ. Тестирование выполняли в день начала исследования и через 1,5 и 3,0 мес. после начала приема пищевых добавок. Результаты. Результаты 3-месячного курса приема биокомплекса гидролизата коллагена показали, что его применение среди спортсменов с хронической нестабильностью голеностопного сустава способствует достоверному улучшению субъективной функциональной стабильности сустава, подтвержденному увеличением индекса CAIT на 18,9 % в основной группе (р < 0,001) по сравнению с группой плацебо, где рост составил 5,6 % (р = 0,021). Заключение. Полученные данные подтверждают существующие доказательства положительного эффекта длительного приема гидролизата коллагена в комбинации с эластином на функциональную стабильность суставно-связочного аппарата, однако дальнейшие исследования необходимы для уточнения его роли в снижении болевого синдрома и улучшении показателей баланса тела.
Литература
1. Дидур М.Д., Выходец И.Т., Хохлина Н.К., Журавлева А.И. Безопасный спорт? Реалии, понятийные и нормативные аспекты // Вестник РГМУ. 2017. Т. 6. С. 18–21. [Didur M.D., Vykhodets I.T., Khokhlina N.K., Zhuravleva A.I. Can Sports be Safe? Reality, Concepts and Regulations. Bulletin of Russian State Medical University, 2017, vol. 6, pp. 18–21. (in Russ.)] DOI: 10.24075/brsmu.2017-06-03
2. Anderson J.E. Key Concepts in Muscle Regeneration: Muscle “Cellular Ecology” Integrates a Gestalt of Cellular Cross-talk, Motility, and Activity to Remodel Structure and Restore Function. European Journal of Applied Physiology, 2022, vol. 122 (2), pp. 273–300. DOI: 10.1007/s00421-021-04865-4
3. Balshaw T.G., Funnell M.P., McDermott E.J., Maden-Wilkinson T.M. The Effect of Specific Bioactive Collagen Peptides on Tendon Remodeling During 15 wk of Lower Body Resistance Training. Medicine & Science in Sports and Exercise, 2023, vol. 55, pp. 2083–2095. DOI: 10.1249/MSS. 0000000000003242
4. Bischof K., Moitzi A.M., Stafilidis S., König D. Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis. Sports Medicine, 2024, vol. 54 (11), pp. 2865–2888. DOI: 10.1007/s40279-024-02079-0
5. Bischof K., Stafilidis S., Bundschuh L., Oesser S. Influence of Specific Collagen Peptides and 12-week Concurrent Training on Recovery-related Biomechanical Characteristics Following Exercise-induced Muscle Damage – a Randomized Controlled Trial. Frontiers Nutrition, 2023, vol. 10, 1266056. DOI: 10.3389/fnut.2023.1266056
6. Centner C., Jerger S., Mallard A., Herrmann A. Supplementation of Specific Collagen Peptides Following High-load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction. Frontiers Physiology, 2022, vol. 13, 838004. DOI: 10.3389/fphys.2022.838004
7. Donovan L., Hart J.M., Saliba S.A., Park J. Rehabilitation for Chronic Ankle Instability With or Without Destabilization Devices: A Randomized Controlled Trial. Journal of Athletic Training, 2016, vol. 51 (3), pp. 233–251. DOI: 10.4085/1062-6050-51.3.09
8. Gribble P.A., Bleakley C.M., Caulfield B.M., Docherty C.L. Consensus Statement of the International Ankle Consortium: Prevalence, Impact and Long-term Consequences of Lateral Ankle Sprains. British Journals Sports Medicine, 2016, vol. 50 (24), pp. 1493–1495. DOI: 10.1136/bjsports-2016-096188
9. Hertel J., Corbett R.O. An Updated Model of Chronic Ankle Instability. Journal of Athletic Training, 2019, vol. 54 (6), pp. 572–588. DOI: 10.4085/1062-6050-344-18
10. Hiller C.E., Refshauge K.M., Bundy A.C. et al. The Cumberland Ankle Instability Tool: a Report of Validity and Reliability Testing. Archives Physical Medicine Rehabilitation, 2006, vol. 87 (9), pp. 1235–1241. DOI: 10.1016/j.apmr.2006.05.022
11. Jelinek H.F., Khalaf K., Poilvet J., Khandoker A.H. The Effect of Ankle Support on Lower Limb Kinematics During the Y-Balance Test Using Non-linear Dynamic Measures. Frontiers in Physiology, 2019, vol. 10, p. 935. DOI: 10.3389/fphys.2019.00935
12. Jerger S., Centner C., Lauber B., Seynnes O. Effects of Specific Collagen Peptide Supplementation Combined with Resistance Training on Achilles Tendon Properties. Scandinavian Journal of Medicine Science in Sports, 2022, vol. 32, pp. 1131–1141. DOI: 10.1111/sms.14164
13. Kirmse M., Oertzen-Hagemann V., de Marées M., Koenig D. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 2019, vol. 11 (5), p. 1154. DOI: 10.3390/nu11051154
14. König D., Kohl J., Jerger S., Centner C. Potential Relevance of Bioactive Peptides in Sports Nutrition. Nutrients, 2021, vol. 13 (11), p. 3997. DOI: 10.3390/nu13113997
15. Lee J., Bridge J.E., Clark D.R., Stewart C.E. Collagen Supplementation Augments Changes in Patellar Tendon Properties in Female Soccer Players. Frontier Physiology, 2023, vol. 14, 1089971. DOI: 10.3389/fphys.2023.1089971
16. Lis D.M., Jordan M., Lipuma T., Smith T. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. International Journal of Sport Nutrition and Exercise Metabolism, 2022, vol. 32, pp. 65–73. DOI: 10.1123/ijsnem.2020-0313
17. Miklovic T.M., Donovan L., Protzuk O.A., Kang M.S. Acute Lateral Ankle Sprain to Chronic Ankle Instability: a Pathway of Sysfunction. The Physician and Sportsmedicine, 2018, vol. 46 (1), pp. 116–122. DOI: 10.1080/00913847.2018.1409604
18. Mobasheri A., Mahmoudian A., Kalvaityte U., Uzieliene I. White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? Current Rheumatology Reports, 2021, vol. 23 (11), p. 78. DOI: 10.1007/s11926-021-01042-6
19. Mohammad A.W., Suhimi N.M., Aziz A.G.K.A., Jamaliah Md.J. Process for Production of Hydrolysed Collagen from Agriculture Resources: Potential for Further Development. Journal of Applied Sciences, 2014, vol. 14 (12), pp. 1319–1323. DOI: 10.3923/jas.2014.1319.1323
20. Roos K.G., Kerr Z.Y., Mauntel T.C., Djoko A. The Epidemiology of Lateral Ligament Complex Ankle Sprains in National Collegiate Athletic Association Sports. The American Journal of Sports Medicine, 2017, vol. 45 (1), pp. 201–209. DOI: 10.1177/0363546516660980
21. Skov K., Oxfeldt M., Thøgersen R., Hansen M. Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate-A Randomized Controlled Trial. Nutrients, 2019, vol. 11 (5), p. 1064. DOI: 10.3390/nu11051064
22. Stüber J., Zech S., Bay R., Qazzaz A. Normative Data of the Visual Analogue Scale Foot and Ankle (VAS FA) for pathological conditions. Foot Ankle Surgery, 2011, vol. 17 (3), pp. 166–172. DOI: 10.1016/j.fas.2010.05.005
23. Tang F., Xiang M., Yin S., Gao P. Meta-analysis of the Dosage of Balance Training on Ankle Function and Dynamic Balance Ability in Patients with Chronic Ankle Instability. Bio Med Central, Musculoskeletal Disorders, 2024, vol. 25 (1), p. 689. DOI: 10.1186/s12891-024-07800-8
24. Thabane L., Hopewell S., Lancaster G.A., Bond C.M. Methods and Processes for Development of a CONSORT Extension for Reporting Pilot Randomized Controlled Trials. Bio Med Central, Pilot and Feasibility Studies, 2016, vol. 2, p. 25. DOI: 10.1186/s40814-016-0065-z
25. Walrand S., Chiotelli E., Noirt F., Mwewa S. Consumption of a Functional Fermented Milk Containing Collagen Hydrolysate Improves the Concentration of Collagen-specific Amino Acids in Plasma. Journal of Agricultural and Food Chemistry, 2008, vol. 56 (17), pp. 7790–7795. DOI: 10.1021/jf800691f
26. Zdzieblik D., Oesser S., Gollhofer A. Improvement of Activity-related knee Joint Discomfort Following Supplementation of Specific Collagen Peptides. Applied Physiology, Nutrition, and Metabolism, 2017, vol. 42 (11), p. 1237. DOI: 10.1139/apnm-2017-0693
2. Anderson J.E. Key Concepts in Muscle Regeneration: Muscle “Cellular Ecology” Integrates a Gestalt of Cellular Cross-talk, Motility, and Activity to Remodel Structure and Restore Function. European Journal of Applied Physiology, 2022, vol. 122 (2), pp. 273–300. DOI: 10.1007/s00421-021-04865-4
3. Balshaw T.G., Funnell M.P., McDermott E.J., Maden-Wilkinson T.M. The Effect of Specific Bioactive Collagen Peptides on Tendon Remodeling During 15 wk of Lower Body Resistance Training. Medicine & Science in Sports and Exercise, 2023, vol. 55, pp. 2083–2095. DOI: 10.1249/MSS. 0000000000003242
4. Bischof K., Moitzi A.M., Stafilidis S., König D. Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis. Sports Medicine, 2024, vol. 54 (11), pp. 2865–2888. DOI: 10.1007/s40279-024-02079-0
5. Bischof K., Stafilidis S., Bundschuh L., Oesser S. Influence of Specific Collagen Peptides and 12-week Concurrent Training on Recovery-related Biomechanical Characteristics Following Exercise-induced Muscle Damage – a Randomized Controlled Trial. Frontiers Nutrition, 2023, vol. 10, 1266056. DOI: 10.3389/fnut.2023.1266056
6. Centner C., Jerger S., Mallard A., Herrmann A. Supplementation of Specific Collagen Peptides Following High-load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction. Frontiers Physiology, 2022, vol. 13, 838004. DOI: 10.3389/fphys.2022.838004
7. Donovan L., Hart J.M., Saliba S.A., Park J. Rehabilitation for Chronic Ankle Instability With or Without Destabilization Devices: A Randomized Controlled Trial. Journal of Athletic Training, 2016, vol. 51 (3), pp. 233–251. DOI: 10.4085/1062-6050-51.3.09
8. Gribble P.A., Bleakley C.M., Caulfield B.M., Docherty C.L. Consensus Statement of the International Ankle Consortium: Prevalence, Impact and Long-term Consequences of Lateral Ankle Sprains. British Journals Sports Medicine, 2016, vol. 50 (24), pp. 1493–1495. DOI: 10.1136/bjsports-2016-096188
9. Hertel J., Corbett R.O. An Updated Model of Chronic Ankle Instability. Journal of Athletic Training, 2019, vol. 54 (6), pp. 572–588. DOI: 10.4085/1062-6050-344-18
10. Hiller C.E., Refshauge K.M., Bundy A.C. et al. The Cumberland Ankle Instability Tool: a Report of Validity and Reliability Testing. Archives Physical Medicine Rehabilitation, 2006, vol. 87 (9), pp. 1235–1241. DOI: 10.1016/j.apmr.2006.05.022
11. Jelinek H.F., Khalaf K., Poilvet J., Khandoker A.H. The Effect of Ankle Support on Lower Limb Kinematics During the Y-Balance Test Using Non-linear Dynamic Measures. Frontiers in Physiology, 2019, vol. 10, p. 935. DOI: 10.3389/fphys.2019.00935
12. Jerger S., Centner C., Lauber B., Seynnes O. Effects of Specific Collagen Peptide Supplementation Combined with Resistance Training on Achilles Tendon Properties. Scandinavian Journal of Medicine Science in Sports, 2022, vol. 32, pp. 1131–1141. DOI: 10.1111/sms.14164
13. Kirmse M., Oertzen-Hagemann V., de Marées M., Koenig D. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 2019, vol. 11 (5), p. 1154. DOI: 10.3390/nu11051154
14. König D., Kohl J., Jerger S., Centner C. Potential Relevance of Bioactive Peptides in Sports Nutrition. Nutrients, 2021, vol. 13 (11), p. 3997. DOI: 10.3390/nu13113997
15. Lee J., Bridge J.E., Clark D.R., Stewart C.E. Collagen Supplementation Augments Changes in Patellar Tendon Properties in Female Soccer Players. Frontier Physiology, 2023, vol. 14, 1089971. DOI: 10.3389/fphys.2023.1089971
16. Lis D.M., Jordan M., Lipuma T., Smith T. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. International Journal of Sport Nutrition and Exercise Metabolism, 2022, vol. 32, pp. 65–73. DOI: 10.1123/ijsnem.2020-0313
17. Miklovic T.M., Donovan L., Protzuk O.A., Kang M.S. Acute Lateral Ankle Sprain to Chronic Ankle Instability: a Pathway of Sysfunction. The Physician and Sportsmedicine, 2018, vol. 46 (1), pp. 116–122. DOI: 10.1080/00913847.2018.1409604
18. Mobasheri A., Mahmoudian A., Kalvaityte U., Uzieliene I. White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? Current Rheumatology Reports, 2021, vol. 23 (11), p. 78. DOI: 10.1007/s11926-021-01042-6
19. Mohammad A.W., Suhimi N.M., Aziz A.G.K.A., Jamaliah Md.J. Process for Production of Hydrolysed Collagen from Agriculture Resources: Potential for Further Development. Journal of Applied Sciences, 2014, vol. 14 (12), pp. 1319–1323. DOI: 10.3923/jas.2014.1319.1323
20. Roos K.G., Kerr Z.Y., Mauntel T.C., Djoko A. The Epidemiology of Lateral Ligament Complex Ankle Sprains in National Collegiate Athletic Association Sports. The American Journal of Sports Medicine, 2017, vol. 45 (1), pp. 201–209. DOI: 10.1177/0363546516660980
21. Skov K., Oxfeldt M., Thøgersen R., Hansen M. Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate-A Randomized Controlled Trial. Nutrients, 2019, vol. 11 (5), p. 1064. DOI: 10.3390/nu11051064
22. Stüber J., Zech S., Bay R., Qazzaz A. Normative Data of the Visual Analogue Scale Foot and Ankle (VAS FA) for pathological conditions. Foot Ankle Surgery, 2011, vol. 17 (3), pp. 166–172. DOI: 10.1016/j.fas.2010.05.005
23. Tang F., Xiang M., Yin S., Gao P. Meta-analysis of the Dosage of Balance Training on Ankle Function and Dynamic Balance Ability in Patients with Chronic Ankle Instability. Bio Med Central, Musculoskeletal Disorders, 2024, vol. 25 (1), p. 689. DOI: 10.1186/s12891-024-07800-8
24. Thabane L., Hopewell S., Lancaster G.A., Bond C.M. Methods and Processes for Development of a CONSORT Extension for Reporting Pilot Randomized Controlled Trials. Bio Med Central, Pilot and Feasibility Studies, 2016, vol. 2, p. 25. DOI: 10.1186/s40814-016-0065-z
25. Walrand S., Chiotelli E., Noirt F., Mwewa S. Consumption of a Functional Fermented Milk Containing Collagen Hydrolysate Improves the Concentration of Collagen-specific Amino Acids in Plasma. Journal of Agricultural and Food Chemistry, 2008, vol. 56 (17), pp. 7790–7795. DOI: 10.1021/jf800691f
26. Zdzieblik D., Oesser S., Gollhofer A. Improvement of Activity-related knee Joint Discomfort Following Supplementation of Specific Collagen Peptides. Applied Physiology, Nutrition, and Metabolism, 2017, vol. 42 (11), p. 1237. DOI: 10.1139/apnm-2017-0693
2. Anderson J.E. Key Concepts in Muscle Regeneration: Muscle “Cellular Ecology” Integrates a Gestalt of Cellular Cross-talk, Motility, and Activity to Remodel Structure and Restore Function. European Journal of Applied Physiology, 2022, vol. 122 (2), pp. 273–300. DOI: 10.1007/s00421-021-04865-4
3. Balshaw T.G., Funnell M.P., McDermott E.J., Maden-Wilkinson T.M. The Effect of Specific Bioactive Collagen Peptides on Tendon Remodeling During 15 wk of Lower Body Resistance Training. Medicine & Science in Sports and Exercise, 2023, vol. 55, pp. 2083–2095. DOI: 10.1249/MSS. 0000000000003242
4. Bischof K., Moitzi A.M., Stafilidis S., König D. Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis. Sports Medicine, 2024, vol. 54 (11), pp. 2865–2888. DOI: 10.1007/s40279-024-02079-0
5. Bischof K., Stafilidis S., Bundschuh L., Oesser S. Influence of Specific Collagen Peptides and 12-week Concurrent Training on Recovery-related Biomechanical Characteristics Following Exercise-induced Muscle Damage – a Randomized Controlled Trial. Frontiers Nutrition, 2023, vol. 10, 1266056. DOI: 10.3389/fnut.2023.1266056
6. Centner C., Jerger S., Mallard A., Herrmann A. Supplementation of Specific Collagen Peptides Following High-load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction. Frontiers Physiology, 2022, vol. 13, 838004. DOI: 10.3389/fphys.2022.838004
7. Donovan L., Hart J.M., Saliba S.A., Park J. Rehabilitation for Chronic Ankle Instability With or Without Destabilization Devices: A Randomized Controlled Trial. Journal of Athletic Training, 2016, vol. 51 (3), pp. 233–251. DOI: 10.4085/1062-6050-51.3.09
8. Gribble P.A., Bleakley C.M., Caulfield B.M., Docherty C.L. Consensus Statement of the International Ankle Consortium: Prevalence, Impact and Long-term Consequences of Lateral Ankle Sprains. British Journals Sports Medicine, 2016, vol. 50 (24), pp. 1493–1495. DOI: 10.1136/bjsports-2016-096188
9. Hertel J., Corbett R.O. An Updated Model of Chronic Ankle Instability. Journal of Athletic Training, 2019, vol. 54 (6), pp. 572–588. DOI: 10.4085/1062-6050-344-18
10. Hiller C.E., Refshauge K.M., Bundy A.C. et al. The Cumberland Ankle Instability Tool: a Report of Validity and Reliability Testing. Archives Physical Medicine Rehabilitation, 2006, vol. 87 (9), pp. 1235–1241. DOI: 10.1016/j.apmr.2006.05.022
11. Jelinek H.F., Khalaf K., Poilvet J., Khandoker A.H. The Effect of Ankle Support on Lower Limb Kinematics During the Y-Balance Test Using Non-linear Dynamic Measures. Frontiers in Physiology, 2019, vol. 10, p. 935. DOI: 10.3389/fphys.2019.00935
12. Jerger S., Centner C., Lauber B., Seynnes O. Effects of Specific Collagen Peptide Supplementation Combined with Resistance Training on Achilles Tendon Properties. Scandinavian Journal of Medicine Science in Sports, 2022, vol. 32, pp. 1131–1141. DOI: 10.1111/sms.14164
13. Kirmse M., Oertzen-Hagemann V., de Marées M., Koenig D. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 2019, vol. 11 (5), p. 1154. DOI: 10.3390/nu11051154
14. König D., Kohl J., Jerger S., Centner C. Potential Relevance of Bioactive Peptides in Sports Nutrition. Nutrients, 2021, vol. 13 (11), p. 3997. DOI: 10.3390/nu13113997
15. Lee J., Bridge J.E., Clark D.R., Stewart C.E. Collagen Supplementation Augments Changes in Patellar Tendon Properties in Female Soccer Players. Frontier Physiology, 2023, vol. 14, 1089971. DOI: 10.3389/fphys.2023.1089971
16. Lis D.M., Jordan M., Lipuma T., Smith T. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. International Journal of Sport Nutrition and Exercise Metabolism, 2022, vol. 32, pp. 65–73. DOI: 10.1123/ijsnem.2020-0313
17. Miklovic T.M., Donovan L., Protzuk O.A., Kang M.S. Acute Lateral Ankle Sprain to Chronic Ankle Instability: a Pathway of Sysfunction. The Physician and Sportsmedicine, 2018, vol. 46 (1), pp. 116–122. DOI: 10.1080/00913847.2018.1409604
18. Mobasheri A., Mahmoudian A., Kalvaityte U., Uzieliene I. White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? Current Rheumatology Reports, 2021, vol. 23 (11), p. 78. DOI: 10.1007/s11926-021-01042-6
19. Mohammad A.W., Suhimi N.M., Aziz A.G.K.A., Jamaliah Md.J. Process for Production of Hydrolysed Collagen from Agriculture Resources: Potential for Further Development. Journal of Applied Sciences, 2014, vol. 14 (12), pp. 1319–1323. DOI: 10.3923/jas.2014.1319.1323
20. Roos K.G., Kerr Z.Y., Mauntel T.C., Djoko A. The Epidemiology of Lateral Ligament Complex Ankle Sprains in National Collegiate Athletic Association Sports. The American Journal of Sports Medicine, 2017, vol. 45 (1), pp. 201–209. DOI: 10.1177/0363546516660980
21. Skov K., Oxfeldt M., Thøgersen R., Hansen M. Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate-A Randomized Controlled Trial. Nutrients, 2019, vol. 11 (5), p. 1064. DOI: 10.3390/nu11051064
22. Stüber J., Zech S., Bay R., Qazzaz A. Normative Data of the Visual Analogue Scale Foot and Ankle (VAS FA) for pathological conditions. Foot Ankle Surgery, 2011, vol. 17 (3), pp. 166–172. DOI: 10.1016/j.fas.2010.05.005
23. Tang F., Xiang M., Yin S., Gao P. Meta-analysis of the Dosage of Balance Training on Ankle Function and Dynamic Balance Ability in Patients with Chronic Ankle Instability. Bio Med Central, Musculoskeletal Disorders, 2024, vol. 25 (1), p. 689. DOI: 10.1186/s12891-024-07800-8
24. Thabane L., Hopewell S., Lancaster G.A., Bond C.M. Methods and Processes for Development of a CONSORT Extension for Reporting Pilot Randomized Controlled Trials. Bio Med Central, Pilot and Feasibility Studies, 2016, vol. 2, p. 25. DOI: 10.1186/s40814-016-0065-z
25. Walrand S., Chiotelli E., Noirt F., Mwewa S. Consumption of a Functional Fermented Milk Containing Collagen Hydrolysate Improves the Concentration of Collagen-specific Amino Acids in Plasma. Journal of Agricultural and Food Chemistry, 2008, vol. 56 (17), pp. 7790–7795. DOI: 10.1021/jf800691f
26. Zdzieblik D., Oesser S., Gollhofer A. Improvement of Activity-related knee Joint Discomfort Following Supplementation of Specific Collagen Peptides. Applied Physiology, Nutrition, and Metabolism, 2017, vol. 42 (11), p. 1237. DOI: 10.1139/apnm-2017-0693
References
1. Дидур М.Д., Выходец И.Т., Хохлина Н.К., Журавлева А.И. Безопасный спорт? Реалии, понятийные и нормативные аспекты // Вестник РГМУ. 2017. Т. 6. С. 18–21. [Didur M.D., Vykhodets I.T., Khokhlina N.K., Zhuravleva A.I. Can Sports be Safe? Reality, Concepts and Regulations. Bulletin of Russian State Medical University, 2017, vol. 6, pp. 18–21. (in Russ.)] DOI: 10.24075/brsmu.2017-06-032. Anderson J.E. Key Concepts in Muscle Regeneration: Muscle “Cellular Ecology” Integrates a Gestalt of Cellular Cross-talk, Motility, and Activity to Remodel Structure and Restore Function. European Journal of Applied Physiology, 2022, vol. 122 (2), pp. 273–300. DOI: 10.1007/s00421-021-04865-4
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Опубликован
2026-10-11
Как цитировать
Поляев, Б., Шишкин, А., Артемьев, С., Артемьева, И., & Демин, Н. (2026). ВЛИЯНИЕ ПРИМЕНЕНИЯ ГИДРОЛИЗАТА КОЛЛАГЕНА В КОМБИНАЦИИ С ЭЛАСТИНОМ НА ФУНКЦИОНАЛЬНУЮ СТАБИЛЬНОСТЬ СУСТАВА СРЕДИ СПОРТСМЕНОВ С ХРОНИЧЕСКОЙ НЕСТАБИЛЬНОСТЬЮ ГОЛЕНОСТОПНОГО СУСТАВА. Человек. Спорт. Медицина, 26(3), 190-197. https://doi.org/10.14529/hsm260323
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Восстановительная и спортивная медицина
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