EVIDENCE FOR EFFECTIVENESS AND FUNCTIONAL PROPERTIES OF SPECIALIZED PRODUCT IN CLINICAL TRIAL
Keywords:
BAA Energiya, clinical trials, effectiveness, functional properties
Abstract
Aim. To perform clinical trials aimed to test effectiveness and functional properties of Energiya biologically active additive (BAA) in people exposed to high psychophysiological loads. Materials and Methods. We conducted clinical trials of new formula of Energiya BAA which contains (mg per 1 tablet): peach leaf (extract) – 100; Rhodiola quadrifida (extract) – 75; zinc asparaginate – 45.5; zinc – 8.5; cystine – 30; ascorbic acid – 25; quercetin – 10; rutin – 10; grape seed (extract) – 5; copper asparaginate – 4.4; copper – 0.7; sodium selenite – 0.11; selenium - 0,05; cifrol-5 (antioxidant complex) – 200. Thirty five volunteers were recruited as participants among people regularly exposed to increased psychophysiological loads: physicians, nurses, teachers, and long-haul drivers. Subjects' diet was supplemented with two tablets of the specialized product per day. The control group comprising 35 participants of similar occupations did not receive any bioactive additives. Levels of lipid peroxidation products and free radical activity were assessed based on malondialdehyde concentration. Microcirculatory vascular disturbances were estimated by rheoencephalography. Quality of life was evaluated in accordance with a factor determining health-related restrictions of physical loads; patient-reported data were also used. Results. It was established that supplementing the volunteers' diet with specialized product reduced the levels of lipid peroxidation products and, thus, reversed the symptoms of microcirculatory disturbances with a simultaneous improvement of quality of life, which could be associated with stabilization of cell membranes and energy metabolism, prevention of oxygen deficiency, and elimination of unfavorable oxidative processes. In the control group such positive changes were not observed. Conclusion. Using BAA Energia as a dietary factor normalizes the microcirculatory function, contributes to overall rehabilitation, and improves the quality of life affected by high psychophysiological loads.References
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3. Poznyakovskiy V.M., Chugunova O.V., Tamova M.Yu. Pishchevye ingredienty i biologicheski aktivnye dobavki [Food Ingredients and Biologically Active Additives]. Moscow, INFRA-M Publ., 2017. 143 p.
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5. Order of the Government of the RF “Fundamentals of the State Policy of the Russian Federation in the Field of Healthy Nutrition of the Population until 2020” of October 25, 2010 № 559-R. (in Russ.)
6. RF Rederal Law “On the Strategy of Scientific and Technological Development of the Russian Federation” of December 1, 2016, № 642. (in Russ.)
7. Chereshnev V.A., Poznyakovskiy V.M. [Problems of Food Security. National and International Aspects]. Industriya pitaniya [The Food Industry], 2016, no. 1 (1), pp. 6–14. (in Russ.)
8. Kromhout D. Omega-3 Fatty Acids and Cardiovascular Events after Myocardial Infarction. N. Engl. J. Med., 2010, vol. 363 (21), pp. 2015–2026. DOI: 10.1056/NEJMoa1003603
9. Lazarus S., Garg M. Tomato Extract Inhibits Human Platelet Aggregation in Vitro Without Increasing Basal CAMP Levels. Int. J. Food Sci. Nutr., 2004, vol. 55, pp. 249–256. DOI: 10.1080/09637480410001734003
10. Lee J.H., O'Keefe H., Lavie C.J. Omega-3 Fatty Acids for Cardioprotection. Mayo Clin. Proc., 2008, vol. 83, pp. 324–332. DOI: 10.4065/83.3.324
11. Singh R.B., Neki N.S. Effect of Coenzyme Q10 on Risk of Atherosclerosis in Patients with Recent Myocardial Infarction. Mol. Cll. Biochem., 2003, vol. 264 (1–2), pp. 75–82. DOI: 10.1023/A:1023408031111
12. Yamamoto J. Tomatoes have Natural Antithrombotic Effects. Br. J. Nutr., 2003, vol. 90, pp. 1031–1038. DOI: 10.1079/BJN2003994
2. Bokeriya L.A. Zdorov'e Rossii: Atlas [Health of Russia. Atlas]. 8nd ed. Moscow, NCBK named after A.N. Bakulev of the Russian Academy of Medical Sciences Publ., 2012. 408 p.
3. Poznyakovskiy V.M., Chugunova O.V., Tamova M.Yu. Pishchevye ingredienty i biologicheski aktivnye dobavki [Food Ingredients and Biologically Active Additives]. Moscow, INFRA-M Publ., 2017. 143 p.
4. Pokrovskiy V.I., Romanenko G.A., Knyazhev V.A., Gerasemenko N.F., Onishchenko G.G., Tutel'yan V.A., Poznyakovskiy V.M. Politika zdorovogo pitaniya. Federal'nyy i regional'nyy urovni [The Policy of Healthy Eating. Federal and Regional Levels]. Novosibirsk, Siberian University Publ., 2002. 344 p.
5. Order of the Government of the RF “Fundamentals of the State Policy of the Russian Federation in the Field of Healthy Nutrition of the Population until 2020” of October 25, 2010 № 559-R. (in Russ.)
6. RF Rederal Law “On the Strategy of Scientific and Technological Development of the Russian Federation” of December 1, 2016, № 642. (in Russ.)
7. Chereshnev V.A., Poznyakovskiy V.M. [Problems of Food Security. National and International Aspects]. Industriya pitaniya [The Food Industry], 2016, no. 1 (1), pp. 6–14. (in Russ.)
8. Kromhout D. Omega-3 Fatty Acids and Cardiovascular Events after Myocardial Infarction. N. Engl. J. Med., 2010, vol. 363 (21), pp. 2015–2026. DOI: 10.1056/NEJMoa1003603
9. Lazarus S., Garg M. Tomato Extract Inhibits Human Platelet Aggregation in Vitro Without Increasing Basal CAMP Levels. Int. J. Food Sci. Nutr., 2004, vol. 55, pp. 249–256. DOI: 10.1080/09637480410001734003
10. Lee J.H., O'Keefe H., Lavie C.J. Omega-3 Fatty Acids for Cardioprotection. Mayo Clin. Proc., 2008, vol. 83, pp. 324–332. DOI: 10.4065/83.3.324
11. Singh R.B., Neki N.S. Effect of Coenzyme Q10 on Risk of Atherosclerosis in Patients with Recent Myocardial Infarction. Mol. Cll. Biochem., 2003, vol. 264 (1–2), pp. 75–82. DOI: 10.1023/A:1023408031111
12. Yamamoto J. Tomatoes have Natural Antithrombotic Effects. Br. J. Nutr., 2003, vol. 90, pp. 1031–1038. DOI: 10.1079/BJN2003994
References on translit
1. Gerasimenko N.F., Poznyakovskiy V.M., Chelnakova N.G. [Healthy Nutrition and Its Role in Ensuring the Quality of Life]. Tekhnologii pishchevoy i pererabatyvayushchey promyshlennosti APK – produkty zdorovogo pitaniya [Technologies of Food and Processing Industry of Agroindustrial Complex – Products of Healthy Food], 2016, no. 4 (12), pp. 52–57. (in Russ.)2. Bokeriya L.A. Zdorov'e Rossii: Atlas [Health of Russia. Atlas]. 8nd ed. Moscow, NCBK named after A.N. Bakulev of the Russian Academy of Medical Sciences Publ., 2012. 408 p.
3. Poznyakovskiy V.M., Chugunova O.V., Tamova M.Yu. Pishchevye ingredienty i biologicheski aktivnye dobavki [Food Ingredients and Biologically Active Additives]. Moscow, INFRA-M Publ., 2017. 143 p.
4. Pokrovskiy V.I., Romanenko G.A., Knyazhev V.A., Gerasemenko N.F., Onishchenko G.G., Tutel'yan V.A., Poznyakovskiy V.M. Politika zdorovogo pitaniya. Federal'nyy i regional'nyy urovni [The Policy of Healthy Eating. Federal and Regional Levels]. Novosibirsk, Siberian University Publ., 2002. 344 p.
5. Order of the Government of the RF “Fundamentals of the State Policy of the Russian Federation in the Field of Healthy Nutrition of the Population until 2020” of October 25, 2010 № 559-R. (in Russ.)
6. RF Rederal Law “On the Strategy of Scientific and Technological Development of the Russian Federation” of December 1, 2016, № 642. (in Russ.)
7. Chereshnev V.A., Poznyakovskiy V.M. [Problems of Food Security. National and International Aspects]. Industriya pitaniya [The Food Industry], 2016, no. 1 (1), pp. 6–14. (in Russ.)
8. Kromhout D. Omega-3 Fatty Acids and Cardiovascular Events after Myocardial Infarction. N. Engl. J. Med., 2010, vol. 363 (21), pp. 2015–2026. DOI: 10.1056/NEJMoa1003603
9. Lazarus S., Garg M. Tomato Extract Inhibits Human Platelet Aggregation in Vitro Without Increasing Basal CAMP Levels. Int. J. Food Sci. Nutr., 2004, vol. 55, pp. 249–256. DOI: 10.1080/09637480410001734003
10. Lee J.H., O'Keefe H., Lavie C.J. Omega-3 Fatty Acids for Cardioprotection. Mayo Clin. Proc., 2008, vol. 83, pp. 324–332. DOI: 10.4065/83.3.324
11. Singh R.B., Neki N.S. Effect of Coenzyme Q10 on Risk of Atherosclerosis in Patients with Recent Myocardial Infarction. Mol. Cll. Biochem., 2003, vol. 264 (1–2), pp. 75–82. DOI: 10.1023/A:1023408031111
12. Yamamoto J. Tomatoes have Natural Antithrombotic Effects. Br. J. Nutr., 2003, vol. 90, pp. 1031–1038. DOI: 10.1079/BJN2003994
Published
2017-09-01
How to Cite
Vekovtsev, A., Tokhiriyon, B., & Chelnakov, A. (2017). EVIDENCE FOR EFFECTIVENESS AND FUNCTIONAL PROPERTIES OF SPECIALIZED PRODUCT IN CLINICAL TRIAL. Human. Sport. Medicine, 17(3), 94-101. https://doi.org/10.14529/hsm170310
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Sports nutrition
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