PAGET – SCHROETTER SYNDROME IN A FOOTBALL PLAYER: GENETIC AND ENVIRONMENTAL RISK FACTORS

DOI: https://doi.org/10.14529/hsm250222
Keywords: Paget-Schrötter syndrome, venous thrombosis of the upper extremities, polymorphic markers for thrombophilia, unfavorable climatic conditions

Abstract

Aim. This paper aims to investigate the genetic predisposition factors of axillary-subclavian venous occlusion. Materials and methods: the diagnosis was confirmed via Doppler ultrasonography. The study investigated polymorphisms in coagulation factor genes using pyrosequencing with commercially available panels. Results. Right axillary-subclavian venous occlusion was associated with point mutations in coagulation factor VII (F7, rs6046), plasminogen activator inhibitor (SERPINE1, rs1799768), and the gene encoding platelet glycoprotein 1b (GP1BA, rs6065). These genetic variants were linked to increased factor production and enhanced platelet adhesion rates, which, combined with climatic conditions, contributed to thrombotic development. Conclusion. Early detection of such predispositions may reduce the risk of severe complications, including pulmonary artery or pericardial vessel thromboembolism.

Author Biographies

P. Postnikov , M.V. Lomonosov Moscow State University, Moscow, Russia

Candidate of Chemical Sciences, Head of the Doping Control Department, National Anti-Doping Laboratory (Institute), Lomonosov Moscow State University, Moscow, Russia.

V. Pavlov , Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia

Doctor of Medical Sciences, Leading Researcher, Head of the Functional Diagnostics Department, Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia.

I. Pronina , M.V. Lomonosov Moscow State University, Moscow, Russia; Emanuel Institute of Biochemical Physics of RAS, Moscow, Russia

Candidate of Biological Sciences, Chief Specialist, Doping Control Department, National Anti-Doping Laboratory (Institute), Lomonosov Moscow State University, Moscow, Russia; Senior Researcher, Laboratory of Chemical Physics of Bioanalytical Processes, Emanuel Institute of Biochemical Physics, Moscow, Russia.

Z. Ordzhonikidze , Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia

Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation, Chief Specialist in Sports Medicine, First Deputy Director, Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia.

V. Badtieva , Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of Moscow Healthcare Department, Moscow, Russia

Academician of the Russian Academy of Sciences (RAS), Doctor of Medical Sciences, Professor, Head of the Department of Sports Medicine and Clinical Pharmacology, Head of Branch No. 1, Moscow Center for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia.

References

References on translit

Published
2025-07-10
How to Cite
Postnikov, P., Pavlov, V., Pronina, I., Ordzhonikidze, Z., & Badtieva, V. (2025). PAGET – SCHROETTER SYNDROME IN A FOOTBALL PLAYER: GENETIC AND ENVIRONMENTAL RISK FACTORS. Human. Sport. Medicine, 25(2), 190-198. https://doi.org/10.14529/hsm250222
Issue
Vol 25 No 2 (2025)
Section
Rehabilitation and sports medicine

Copyright (c) 2025 Human. Sport. Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.