EFFECT OF SEROTONIN ON CARDIAC OUTPUT DURING EXERCISE OF DIFFERENT INTENSITY

Keywords: serotonin 5-HT2 receptor agonist, rat, heart rate, stroke volume, minute volume, swimming exercise

Abstract

Abstract. Aim. The paper aims to identify the effect of the serotonin 5-HT2 receptor agonist on cardiac output in rats during exercise of different intensity. Materials and methods. Two types of swimming training sessions were used (endurance training, speed training). Laboratory rats of different performance levels received the serotonin 5-HT2 receptor agonist, then changes in cardiac output were recorded. Results. There was a decrease in HR in older rats and in rats subjected to exercise, particularly that of endurance nature. The indices of stroke volume and minute volume increased with age and as a result of exercise. The results indicated that the younger the rat the more pronounced changes were found in cardiac output. Rats subjected to speed training had higher values of minute volume after the administration of the serotonin 5-HT2 receptor agonist. Conclusion. In rats, the chronotropic response of cardiac output to various doses of the serotonin 5-HT2 receptor agonist decreases with age, while inotropic response increases with age and as a result of exercise. Endurance training results in more pronounced changes in the cardiac pump function compared with speed training.

Author Biographies

R. Abzalov , Kazan (Volga region) Federal University, Kazan, Russia

Doctor of Biological Sciences, Associate Professor, Professor of the Department of Theory and Methods of Physical Education, Sport and Physical Therapy, Institute of Basic Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russia.

N. Abzalov , Kazan (Volga region) Federal University, Kazan, Russia

Doctor of Biological Sciences, Associate Professor, Head of the Department of Theory and Methods of Physical Education, Sport and Physical Therapy, Institute of Basic Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russia.

R. Abzalov , Kazan (Volga region) Federal University, Kazan, Russia

Doctor of Biological Sciences, Professor, Professor of the Department of Theory and Methods of Physical Education, Sport and Physical Therapy, Institute of Basic Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russia.

References

References on translit

Published
2022-04-12
How to Cite
Abzalov, R., Abzalov, N., & Abzalov, R. (2022). EFFECT OF SEROTONIN ON CARDIAC OUTPUT DURING EXERCISE OF DIFFERENT INTENSITY. Human. Sport. Medicine, 22(1), 50-55. https://doi.org/10.14529/hsm220107
Section
Physiology