DIAGNOSED BRONCHIAL ASTHMA IN CHILDREN WITH KNOWN EPISODES OF ACUTE BRONCHITIS AT AN EARLY AGE: EVIDENCE BASED ON TEN YEARS OF EXPERIENCE
Abstract
Though there is a specific national program, guidelines, and international consensus paper, diagnosis of bronchial asthma (BA) in preschoolers is still a challenge for practitioners. The main disease to be distinguished from BA is acute bronchitis (AB). Aim. To determine the age of diagnosis of bronchial asthma for children with known episodes of acute bronchitis at an early age and to find out clinical/laboratory features of bronchial asthma in such patients. Materials and Methods. The research involved 72 children with a history of AB who were divided into 2 groups. The average age of children was 3.2 ± 1.3, the number of known episodes of obstructive bronchitis in past medical history was – 2.0 [1.0–3.0] (Me; 25–75 %). Results. Out of 72 children with a history of AB, BA was diagnosed in 32 (44.4 %); 25 of them (78 %) were diagnosed with asthma at the age of 5 or earlier. The analysis of the inflammatory phenotype of induced sputum in children with BA revealed paucigranulocytic type in 4 children (13 %), mixed type in 2 (6 %), and eosinophilic type in 26 (81 %). It was found that children with a history of AB who had a dynamic increase of eosinophil levels in induced sputum by 5% or more, irrespective of the baseline levels of eosinophils in induced sputum, developed bronchial asthma in 95.2 % of cases.References
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2. Zhakov Ya.I., Rybakova O.G., Minina E.E., Medvedeva L.V. [Clinical and Medical History, and Laboratory Features in Children at Risk for the Formation of Asthma]. Sibirskiy meditsinskiy zhurnal (Irkutsk) [Siberian Journal of Medicine (Irkutsk)], 2015, no. 5, pp. 31–34. (in Russ.)
3. Mizernitskiy Yu.L. [Differential Diagnosis and Differentiated Treatment of Acute Bronchial Obstruction with SARS in Infants]. Prakticheskaya meditsina [Practical Medicine], 2014, no. 9 (85), pp. 82–88. (in Russ.)
4. Minina E.E., Medvedeva L.V., Zhakov Ya.I., Belov A.V., Potapov T., Chuprov L.F. [The Use of Non-Invasive Methods to Assess the Cyto-Immunological Parameters in Children with Mild Intermittent Asthma]. Mezhdunarodna nauchna shkola “Paradigma”. Lyato-2015: sbornik nauchnykh statii 7 tom [International Scientific School Paradigm. Lato 2015. Collection of Scientific Articles is 7], 2015, pp. 223–229.
5. Mitskevich S.E., Fedorov I.A. [Analysis of the Application Ribomunil Effectiveness in Children with Persistent Asthma]. Pediatriya. Zhurnal im G.N. Speranskogo [Pediatrics. They Magazine G.N. Speransky], 2015, vol. 94, no. 3, pp. 142–148. (in Russ.)
6. Natsional'naya programma “Bronkhial'naya astma u detey. Strategiya lecheniya i profilaktika” [The National Program Bronchial Asthma in Children. Treatment and Prevention Strategies]. 4nd ed. Moscow, Original Layout Publ., 2012. 184 p.
7. Kulichkov V.I., Mizernitskiy Yu.L., Rybakova O.G., Minina E.E., Zhakov Ya.I. Sposob polucheniya indutsirovannoy mokroty u detey dlya otsenki stepeni i kharaktera vospaleniya slizistoy bronkhov [Method for Producing Induced Sputum in Children to Assess the Extent and Nature of the Bronchial Mucosa Inflammation]. Patent RF, no. 2364341, 2009.
8. Fedorov I.A., Teplova S.N., Zhakov Ya.I. [The Nature of the Microflora of the Respiratory Tract, and Immunological Parameters in Severe Asthma in Children]. Zhurnal mikrobiologii, epidemiologii i immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology], 1999, no. 3, pp. 58–61. (in Russ.)
9. Brozek G., Lawson J., Shpakou A. Childhood Asthma Prevalence and Risk Factors in Three Eastern European Countries – the Belarus, Ukraine, Poland Asthma Study (BUPAS): An International Prevalence Study. BMC Pulm Med., 2016, vol. 16, no. 1, p. 11.
10. Fedorov I.A., Rybakova O.G., Kravets O.Ja. Analysis of Clinical, Anamnestic and Laboratory Data in Children with Asthma and Children with a Risk of Asthma Development. Selected Papers of the International Scientific School “Paradigma” Winter-2016 (Varna, Bulgaria). Yelm, 2016. pp. 24–31.
11. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Available at: http://www.ginasthma.com (accessed 17.06.2015).
12. Yoshihara S., Munkhbayarlakh S., Makino S. Prevalence of Childhood Asthma in Ulaanbaatar, Mongolia in 2009. Allergology International, 2016, vol. 65, no. 1, pp. 62–67. DOI: 10.1016/j.alit.2015.07.009
13. Schleich F.N., Manise M., Sele J. Distribution of Sputum Cellular Phenotype in a Large Asthma Cohort. Predicting Factors for Eosinophilic VS Neutrophilic Inflammation BMC. Pulmonary Medicine, 2013, vol. 13, p. 11.
14. Sha L., Shao M., Liu C. The Prevalence of Asthma in Children. A Comparison Between the Year of 2010 and 2000 in Urban China. Zhonghua Jie He He Hu Xi Za Zhi, 2015, vol. 38, no. 9, pp. 664–668.
15. Staticescu S., Chereches-Panta P., Ichim G. The Value of Induced Sputum in the Diagnosis and Management of Children with Bronchial Asthma. Clujul Medical, 2014, vol. 87(3), pp. 171–176. DOI: 10.15386/cjmed-284
References on translit
Published
2017-02-01
How to Cite
Fedorov, I., Rybakova, O., & Stepanov, O. (2017). DIAGNOSED BRONCHIAL ASTHMA IN CHILDREN WITH KNOWN EPISODES OF ACUTE BRONCHITIS AT AN EARLY AGE: EVIDENCE BASED ON TEN YEARS OF EXPERIENCE. Human. Sport. Medicine, 17(1), 28-35. https://doi.org/10.14529/hsm170103
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Clinical and Experimental Medicine
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