BREAST CANCER ASSOCIATED WITH PREGNANCY
Keywords:
breast cancer, pregnancy, chemotherapy, surgery
Abstract
Aim. To assess the influence of pregnancy on the long-term prognosis and clinical treatment of breast cancer (BC). Materials and Methods. We assessed hereditary and family history and studied the features of BC treatment against the background of pregnancy. All women received complex treatment. Treatment in women with BC associated with pregnancy was the following: in 100 % of cases there was polychemotherapy (PCT); surgical treatment – 44 (88 %) including adnexectomy in 12 (24 %); radiation therapy – 33 (66 %); hormonotherapy (HT) – 25 (50 %). Results. All women received complex treatment. All patients subjected to special treatment (surgery, chemotherapy) during pregnancy had healthy babies. There was no negative influence on the fetal development and condition of newborns (Apgar score – 7 to 9). Conclusion. The decision on special treatment for such patients is made individually. PCT during pregnancy does not affect physical development of newborns. It is necessary to perform further research, analyze BRCA mutations, and collect epidemiologic data in patients with BS associated with pregnancy.References
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2. Alexander A., Samlowski W.E., Grossman D. Metastatic Melanoma in Pregnancy: Risk of Transplacental Metastases in the Infant. J. Clin. Oncol., 2003, no. 21, pp. 2179–2186. DOI: 10.1200/JCO.2003.12.149
3. Amant F. Breast Cancer in Pregnanci. Recomendations of an Internacional Consensus Meeting. Eur I Cancer., 2010. 10 p.
4. Applewhite R.R., Smith L.R., Divencenti F. Carcinoma of the Breast Associated with Pregnancy and Lactation. Am Surg., 1973, vol. 39, pp. 101–104.
5. Gemignani M.L., Petrek J.A. Pregnancy after Breast Cancer. Cancer Control., 1999, no. 6, pp. 272–276.
6. Greskovich J.J., Macklis R. Radiation Therapy in Pregnancy: Risk Calculation and Risk Minimization. Semin. Oncol., 2000, vol. 27, pp. 633–645.
7. Kuerer H.M., Gwyn K., Ames F.C. Conservative Surgery and Chemotherapy for Breast Carcinoma During Pregnancy. Surgery, 2002, vol. 131, pp. 108–110. DOI: 10.1067/msy.2002.115357
8. NCCN / National Comprehensive Cancer Network. 2015, pp. 60–61.
9. Pavlidis N., Panteroudakis G. The Pregnant Mother with Breast Cancer: Diagnostic and Therapeutic Mana-Gement. Cancer Treat. Rev., 2005, no. 31, pp. 439–447. DOI: 10.1016/j.ctrv.2005.04.010
10. Protection ICoR. Biological Effects after Prenatal Irradiation (Embryo and Fetus). Ann. ICRP, 2003, no. 33, pp. 205–206.
11. Saber A., Dardik H., Ibrahim I.M. The Milk Rejection Sign: A Natural Tumor Marker. Am. Surg., 1996, vol. 62, pp. 998–999.
12. Vujovie O., Cherian A.Yu.E. The Effect of Timing of Radiotherapy after Breast-Conserving Surgery in Patients with Positive or Close Resection Margins, Young Age, and Node-Negative Disease, with Long-Terms Follow-Up. Int. J. Radiat. Oncol. Biol. Phys., 2006, no. 66, pp. 687–690. DOI: 10.1016/j.ijrobp.2006.05.051
13. Walshe J.M., Denduluri N., Swain S.M. Amenorrhea in Premenopausal Women after Adjuvant Chemotherapy for Breast Cancer. J. Clin. Oncol., 2006, no. 24, pp. 5769–5779. DOI: 10.1200/JCO.2006.07.2793
14. Whelan T., MacKenzie R., Julian J. Randomised Trial of Breast Irradiation Schedules after Lumpectomy for Women with Lymph Nodenagative Breast Cancer. J. Natl Cancer Inst., 2002, no. 94, pp. 1143–1150. DOI: 10.1093/jnci/94.15.1143
15. White T.T. Prognosis for Breast Cancer for Pregnant and Nursing Women: Analysis of 1413 Cases. Surg Gynecol Obstet., 1995, vol. 100, pp. 661–666.
References on translit
Published
2016-12-01
How to Cite
Nadvikova, A., Vazhenin, A., Tereshin, O., Bulynskiy, D., Udovichenko, I., & Maltseva, S. (2016). BREAST CANCER ASSOCIATED WITH PREGNANCY. Human. Sport. Medicine, 16(4), 27-31. https://doi.org/10.14529/hsm160403
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Section
Clinical and Experimental Medicine
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