LC/MS ANALYSIS OF CARNITINE METABOLISM IN YOUNG ATHLETES

DOI: https://doi.org/10.14529/hsm230305
Keywords: young athletes, free and bound carnitine, acylcarnitines, liquid chromatography-mass spectrometry

Abstract

Aim. The paper aims to compare the levels of carnitine metabolites depending on physical performance in young athletes. Materials and methods. The study involved 12 athletes and 7 young males who do not have any regular, intense physical activity as a control group. The levels of free carnitine (C0) and acylcarnitines in blood plasma were measured using liquid chromatography-mass spectrometry (LC/MS). Results. All parameters of carnitine metabolism in young athletes and untrained males are within the normal range. Analysis of the main metabolic parameters showed no significant intergroup differences in both free and bound carnitine and acylcarnitines. Significant differences were observed with respect to the acylcarnitine/carnitine ratio in the compared groups (p = 0.018). Positive correlations were found between bound carnitine and C14 (tetradecanoylcarnitine) (r = 0.65; p = 0.022), as well as between the AC/C0 ratio and C14 (r = 0.72; p = 0.007) in the blood plasma of athletes. Conclusion. Further study of carnitine metabolism in athletes will make it possible to predict their physical performance and prevent health deterioration due to intense physical exercise.

Author Biographies

A. Lyudinina , Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia

Candidate of Biological Sciences, Senior Researcher, Department of Ecological and Medical Physiology, Institute of Physiology, Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

Z. Ivankova , Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia

Candidate of Biological Sciences, Researcher, Department of Ecological and Medical Physiology, Institute of Physiology, Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

A. Samoylov , Russian State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia

Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, General Director, Russian State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia.

N. Rylova , Russian State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia

Doctor of Medical Sciences, Professor, Head of the Laboratory of Sports Nutrition, Center for Sports Medicine and Rehabilitation, Russian State Research Center − Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia.

E. Boyko , Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia

Doctor of Medical Sciences, Professor, Director of the Institute of Physiology, Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

References

References on translit

Published
2023-12-27
How to Cite
Lyudinina, A., Ivankova, Z., Samoylov, A., Rylova, N., & Boyko, E. (2023). LC/MS ANALYSIS OF CARNITINE METABOLISM IN YOUNG ATHLETES. Human. Sport. Medicine, 23(3), 39-46. https://doi.org/10.14529/hsm230305
Issue
Vol 23 No 3 (2023)
Section
Physiology

Copyright (c) 2023 Human. Sport. Medicine

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