AUTONOMIC REGULATION AND ITS IMPACT ON REPRODUCTIVE PROFILES IN WOMEN ACROSS DIFFERENT ADIPOSE TISSUE ACTIVITY LEVELS

Abstract

Aim. This study aims to investigate the role of autonomic and metabolic pathways in shaping the reproductive profiles of young women, with a particular focus on the influence of adipose tissue activity levels. Materials and methods. The study involved women aged 18 to 40 years, stratified into three groups based on adipose tissue activity: those with normal body weight, underweight, and overweight. Utilizing the “Varicard 2.51” device, distinct patterns of autonomic regulation have been identified within each group. The Baevsky index, indicative of the balance between sympathetic and parasympathetic systems, served as a key metric, alongside the measurement of SDNN and pNN50. Additionally, enzyme-linked immunosorbent assays (ELISAs) were employed to quantify gonadotropic and sex hormones. Blood samples were collected with respect to various phases of the menstrual cycle to account for hormonal fluctuations. Results. Women with normal body weight made up the main group, the smallest number of subjects was in the group of underweight women. Our findings reveal a predominance of normotonics among women with normal body weight, sympathetic regulation in the overweight group, and vagotonic regulation in the overweight group. Notably, variations in autonomic tone were correlated with the concentration of follicle-stimulating hormone (FSH), while the levels of luteinizing hormone (LH) remained relatively stable across groups. The dynamic nature of adipose tissue significantly influenced the secretion rates of sex hormones, with the baseline tone of the autonomic system contributing to the strongest correlations between gonadotropin concentrations and the SI. Less pronounced correlations were recorded between autonomic regulation and sex hormones. Conclusion. This study underscores the critical interplay between autonomic regulation, metabolic factors, and reproductive health, particularly highlighting the pivotal role of adipose tissue dynamics in modulating the production of sex hormones and the effect of the autonomic tone on the release of gonadotropins.