CLINICAL AND DEMOGRAPHIC FEATURES IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS
Keywords:
External genital endometriosis, past medical history, clinical features of external genital endometriosis, genital infection.
Abstract
Aim. To study the anamnesis and clinical features in women with endometriosis. Materials and Methods. 182 women with endometriosis aged 20 to 45 were examined. The diagnosis of endometriosis was established during laparoscopy. The control group comprised 44 women without endometriosis. The classification of the American Society for Reproductive Medicine R-AFS (1996) was used to assess the severity of endometriosis. All women underwent bacteriological examination of cervical mucus. The study of endometrium, peritoneal fluid, endometrioid heterotopia for the presence of pathogens of genital infection was performed using PCR (polymerase chain reaction) method. Results. The most frequent concomitant gynecological pathology in women with endometriosis was chronic inflammatory diseases. In 45 (24.7 %) women with endometriosis, aerobic and anaerobic Gram-variable rods and cocci were detected. Pathogens of genital infection were found in 47 (25.8 %) women with endometriosis in the endometrium, in 5 (2.7 %) in the peritoneal fluid and in 21 (13.3 %) in the foci of endometriosis. The frequency of detection of the causative agents of genital infection in the endometrium was 20 to 29 %, in peritoneal fluid – from 1 to 4 %, and in endometrioid heterotopia – from 11 to 15 %. Conclusion. Women with endometriosis often have chronic inflammatory diseases and genital infections. About 50% of women have concomitant somatic pathology. In the examination of women with endometriosis, genital infection pathogens were detected in light and severe stages of the disease in endocervix, endometrium, peritoneal fluid, endometrioid heterotopia.References
1. Baskakov V.P., Tsvelev Yu.V., Kira E.F. Endometrioidnaya bolezn' [Endometriosis Disease]. St. Petersburg, N-L Publ., 2002. 448 p.
2. Damirov M.M. Genital'nyy endometrioz – bolezn' aktivnykh i delovykh zhenshchin [Genital Endometriosis is a Disease of Active and Business Women]. Moscow, BINOM Publ., 2010. 191 p.
3. Ishchenko A.I., Kudrina E.A. Endometrioz. Sovremennye aspekty [Endometriosis. Modern Aspects]. Moscow, MIA Publ., 2008. 172 p.
4. Leskov V.P., Gavrilova E.F., Pishchulin A.A. [Changes in the Immune System with Internal Endometriosis]. Problemy reproduktsii [Problems of Reproduction], 1998, no. 4, pp. 26?30. (in Russ.)
5. Marchenko L.A., Lushkova I.P., Prilepskaya V.N. (Ed.) Patologiya sheyki matki i genital'nye infektsii [Pathology of the Cervix and Genital Infections]. Moscow, MED Press Information Publ., 2008. 172 p.
6. Oppelt P., Renner S.P., Strick R., Valletta D., Mehlhorn G., Fasching P.A., Beckmann M.W., Strissel P.L. Correlation of High ? Risk Human Papillomavirus es but not of Herpes Viruses or Chlamydia Trachomatis with Endometriosis Lesions. Fertility and Sterility, 2010, vol. 93, no. 6, pp. 1778?1786. DOI: 10.1016/j.fertnstert.2008.12.061
7. Hu L., Hornung D., Kurek R., Ostman H., Blomberg J., Bergqvist A. Expression of Human Endogenous Gamma Retroviral Sequences in Endometriosis and Ovarian Cancer. AIDS Research and Human Retroviruses, 2006, vol. 22, no. 6, pp. 551?557. DOI: 10.1089/aid.2006.22.551
8. Oppelt P., Strick R., Strissel P.L., Winzierl K., Beckmann M.W., Renner S.P. Expression of the Human Endogen Ous Retro Virus-Wenvelopegene Syncytin in Endometriosis Lesion. Gynecol Endocrinol., 2009, vol. 25, no. 11, pp. 741?747. DOI: 10.3109/09513590903184142
9. Vestergaard A.L., Knudsen U.B., Munk T., Rosbach H., Bialasiewicz S., Sloots T.P., Martensen P.M., Antonsson A. Low Prevalence of DNA Viruses in the Human Endometrium and Endometriosis. Arch Virol., 2010, vol. 155, no. 5, pp. 695?703. DOI: 10.1007/s00705-010-0643-y
10. Martensen P.M., Vestergaard A.L., Knudsen U.B. Virus Infection and Tipe I Interferon in Endometriosis. Endometriosis – Basic Concepts and Current Reserch Trends, 2012, 490 p. Available at: http:www.intechopen/com.
11. Nisolle M., Casanas-Roux F., Donnez J. Early ? Stage Endometriosis. Adhesion and Growth of Human Menstrual Endometrium in Nudemice. Fertil Steril., 2000, vol. 74(2), pp. 306?312. DOI: 10.1016/S0015-0282(00)00601-4
12. Kobayashi H., Higashiura Y., Shigetomi H., Kajihara H. Pathogenesis оf Endometriosis. The Role of Initial Infection and Subsequent Sterile Inflammation (Review). Mol Med Rep. 2014, no. 9(1), pp. 9?15. DOI: 10.3892/mmr.2013.1755
13. Kodati V.L., Govindan S., Movva S., Ponnala S., Hasan Q. Role of Shigella Infection in Endometriosis. Anovel Hypothesis. Med Hypotheses, 2008, no. 70 (2), pp. 239?243.
2. Damirov M.M. Genital'nyy endometrioz – bolezn' aktivnykh i delovykh zhenshchin [Genital Endometriosis is a Disease of Active and Business Women]. Moscow, BINOM Publ., 2010. 191 p.
3. Ishchenko A.I., Kudrina E.A. Endometrioz. Sovremennye aspekty [Endometriosis. Modern Aspects]. Moscow, MIA Publ., 2008. 172 p.
4. Leskov V.P., Gavrilova E.F., Pishchulin A.A. [Changes in the Immune System with Internal Endometriosis]. Problemy reproduktsii [Problems of Reproduction], 1998, no. 4, pp. 26?30. (in Russ.)
5. Marchenko L.A., Lushkova I.P., Prilepskaya V.N. (Ed.) Patologiya sheyki matki i genital'nye infektsii [Pathology of the Cervix and Genital Infections]. Moscow, MED Press Information Publ., 2008. 172 p.
6. Oppelt P., Renner S.P., Strick R., Valletta D., Mehlhorn G., Fasching P.A., Beckmann M.W., Strissel P.L. Correlation of High ? Risk Human Papillomavirus es but not of Herpes Viruses or Chlamydia Trachomatis with Endometriosis Lesions. Fertility and Sterility, 2010, vol. 93, no. 6, pp. 1778?1786. DOI: 10.1016/j.fertnstert.2008.12.061
7. Hu L., Hornung D., Kurek R., Ostman H., Blomberg J., Bergqvist A. Expression of Human Endogenous Gamma Retroviral Sequences in Endometriosis and Ovarian Cancer. AIDS Research and Human Retroviruses, 2006, vol. 22, no. 6, pp. 551?557. DOI: 10.1089/aid.2006.22.551
8. Oppelt P., Strick R., Strissel P.L., Winzierl K., Beckmann M.W., Renner S.P. Expression of the Human Endogen Ous Retro Virus-Wenvelopegene Syncytin in Endometriosis Lesion. Gynecol Endocrinol., 2009, vol. 25, no. 11, pp. 741?747. DOI: 10.3109/09513590903184142
9. Vestergaard A.L., Knudsen U.B., Munk T., Rosbach H., Bialasiewicz S., Sloots T.P., Martensen P.M., Antonsson A. Low Prevalence of DNA Viruses in the Human Endometrium and Endometriosis. Arch Virol., 2010, vol. 155, no. 5, pp. 695?703. DOI: 10.1007/s00705-010-0643-y
10. Martensen P.M., Vestergaard A.L., Knudsen U.B. Virus Infection and Tipe I Interferon in Endometriosis. Endometriosis – Basic Concepts and Current Reserch Trends, 2012, 490 p. Available at: http:www.intechopen/com.
11. Nisolle M., Casanas-Roux F., Donnez J. Early ? Stage Endometriosis. Adhesion and Growth of Human Menstrual Endometrium in Nudemice. Fertil Steril., 2000, vol. 74(2), pp. 306?312. DOI: 10.1016/S0015-0282(00)00601-4
12. Kobayashi H., Higashiura Y., Shigetomi H., Kajihara H. Pathogenesis оf Endometriosis. The Role of Initial Infection and Subsequent Sterile Inflammation (Review). Mol Med Rep. 2014, no. 9(1), pp. 9?15. DOI: 10.3892/mmr.2013.1755
13. Kodati V.L., Govindan S., Movva S., Ponnala S., Hasan Q. Role of Shigella Infection in Endometriosis. Anovel Hypothesis. Med Hypotheses, 2008, no. 70 (2), pp. 239?243.
References on translit
Published
2017-06-01
How to Cite
Zainetdinova, L., Telesheva, L., Shamaeva, T., & Koryaushkina, A. (2017). CLINICAL AND DEMOGRAPHIC FEATURES IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS. Human. Sport. Medicine, 17(2), 52-61. https://doi.org/10.14529/hsm170205
Issue
Section
Clinical and Experimental Medicine
Copyright (c) 2019 Human. Sport. Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
