ASSOCIATION OF CANDIDATE GENES REGULATING PROTEOLYTIC SYSTEMS WITH RUNNING PERFORMANCES AT DIFFERENT DISTANCES

DOI: https://doi.org/10.14529/hsm25s106
Keywords: renin-angiotensin system, kallikrein-kinin system, rs4340 ACE gene polymorphism, BDKRB2 rs5810761 gene polymorphism, cyclic sports, sports qualification

Abstract

Aim. This study aimed to investigate the association between polymorphisms in candidate genes involved in proteolytic regulation and running performances on different distances. Materials and methods. Genotyping was performed in 123 male athletes (speed skaters and track and field runners specializing in short-, middle-, or long-distance events) and 50 healthy non-athlete controls using real-time polymerase chain reaction (StepOne Real-Time PCR System, Applied Biosystems, USA). Results. The deletion allele (D) and homozygous genotype (DD) of the ACE rs4340 polymorphism were associated with enhanced sprint performance. The homozygous II genotype was linked to enhanced long-distance running performance. Conclusion. These findings suggest that genetic markers may serve as predictors for athletic performance at different running distances. Incorporating genetic profiling into sports selection could enable coaches and sports physicians to optimize athlete specialization, enhance performance, and mitigate risks of overtraining and maladaptation during competitive periods.

Author Biographies

E. Bykov , Ural State University of Physical Education, Chelyabinsk, Russia

Doctor of Medical Sciences, Professor, Vice-Rector for Research, Ural State University of Physical Education, Chelyabinsk, Russia.

O. Balberova , Ural State University of Physical Education, Chelyabinsk, Russia

Candidate of Biological Sciences, Senior Researcher at the Scientific Research Institute of Olympic Sports, Ural State University of Physical Education, Chelyabinsk, Russia.

I. Oreshkina , Ural State University of Physical Education, Chelyabinsk, Russia

Candidate of Pedagogical Sciences, Associate Professor, Head of the Department of Theory and Methodology of Speed Skating, Ural State University of Physical Education,  Chelyabinsk, Russia.

N. Makarova , Ural State University of Physical Education, Chelyabinsk, Russia

Candidate of Pedagogical Sciences, Associate Professor of the Department of Theory and Methodology of Athletics, Ural State University of Physical Education, Chelyabinsk, Russia.

References

References on translit

Published
2025-06-30
How to Cite
Bykov, E., Balberova, O., Oreshkina, I., & Makarova, N. (2025). ASSOCIATION OF CANDIDATE GENES REGULATING PROTEOLYTIC SYSTEMS WITH RUNNING PERFORMANCES AT DIFFERENT DISTANCES. Human. Sport. Medicine, 25(S1), 52-58. https://doi.org/10.14529/hsm25s106
Issue
Vol 25 No S1 (2025)
Section
Physiology

Copyright (c) 2025 Human. Sport. Medicine

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