CORRELATION BETWEEN OXIDATIVE METABOLISM AND MICRONUTRIENTS WITH ANTIOXIDANT ACTIVITY IN YAMALO-NENETS AUTONOMOUS DISTRICT ADULTS

Abstract

Aim. The paper aims to identify the correlations between oxidative metabolism and the concentrations of vitamins A, E, C, selenium and zinc in non-indigenous adults of the Yamalo-Nenets Autonomous District (YNAD). Materials and methods. 86 non-indigenous YNAD residents were examined (35 males and 51 females, 38.3 ± 9.6 years). Blood lipid peroxidation pro­ducts were identified with test kits: lipid hydroperoxides (LOOH), thiоbarbituric acid-reactive products (TBA-RP) and antioxidant system (AOS) profile, including total antioxidant activity (TAA), thiol status (TS), vitamin C levels. Serum vitamins A and E were measured by the fluorometric method. Se and Zn contents in hair were determined by the atomic emission spectroscopy and mass spectrometry methods. Results. Increased levels of LOOH and TBA-RP were found in almost a third of cases. The average values of AOS components were closer to the lower limit of normal, while the vitamin E level was below it. The deficiency of AOS components of varying severity was found in 7–49 % of cases. Significant direct correlations were identified between vitamins (A, E, C) and trace elements (Se, Zn), on the one hand, and TAA and TS, on the other hand (r = +0.711 … +0.523). Moreover, inverse relationships were found between these indicators with LOOH and TBA-RP levels (r = –0.659 …–0.458). Conclusion. Significant correlations between LOOH and AOS values indicate: 1) a direct dependence of antioxidant defense on antioxidant vitamins and trace elements; 2) the prospects for improving antioxidant reserves through nutrition and the use of vitamins and trace elements in the form of food supplements.