CORRELATION BETWEEN OXIDATIVE METABOLISM AND MICRONUTRIENTS WITH ANTIOXIDANT ACTIVITY IN YAMALO-NENETS AUTONOMOUS DISTRICT ADULTS

Keywords: northern region, oxidative metabolism, antioxidant vitamins, selenium, zinc

Abstract

Aim. The paper aims to identify the correlations between oxidative metabolism and the concentrations of vitamins A, E, C, selenium and zinc in non-indigenous adults of the Yamalo-Nenets Autonomous District (YNAD). Materials and methods. 86 non-indigenous YNAD residents were examined (35 males and 51 females, 38.3 ± 9.6 years). Blood lipid peroxidation pro­ducts were identified with test kits: lipid hydroperoxides (LOOH), thiоbarbituric acid-reactive products (TBA-RP) and antioxidant system (AOS) profile, including total antioxidant activity (TAA), thiol status (TS), vitamin C levels. Serum vitamins A and E were measured by the fluorometric method. Se and Zn contents in hair were determined by the atomic emission spectroscopy and mass spectrometry methods. Results. Increased levels of LOOH and TBA-RP were found in almost a third of cases. The average values of AOS components were closer to the lower limit of normal, while the vitamin E level was below it. The deficiency of AOS components of varying severity was found in 7–49 % of cases. Significant direct correlations were identified between vitamins (A, E, C) and trace elements (Se, Zn), on the one hand, and TAA and TS, on the other hand (r = +0.711 … +0.523). Moreover, inverse relationships were found between these indicators with LOOH and TBA-RP levels (r = –0.659 …–0.458). Conclusion. Significant correlations between LOOH and AOS values indicate: 1) a direct dependence of antioxidant defense on antioxidant vitamins and trace elements; 2) the prospects for improving antioxidant reserves through nutrition and the use of vitamins and trace elements in the form of food supplements.

Author Biographies

L. Bikbulatova , Salekhard Regional Clinical Hospital, Salekhard, Russian Federation

Head of Laboratory Department, Salekhard District Clinical Hospital. 629001, Salekhard

V. Korchin , Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation

Doctor of Medical Sciences, Professor, Head of the Department of Normal and Pathological Physiology, Khanty-Mansiysk State Medical Academy. 628011, Khanty-Mansiysk

T. Korchina , Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation

Doctor of Medical Sciences, Professor, Professor of the Department of Anesthesiology-Resuscitation, Emergency Medicine and Clinical Toxicology, Khanty-Mansiysk State Medical Academy, 628011, Khanty-Mansiysk

References

References on translit

Published
2022-02-02
How to Cite
Bikbulatova, L., Korchin, V., & Korchina, T. (2022). CORRELATION BETWEEN OXIDATIVE METABOLISM AND MICRONUTRIENTS WITH ANTIOXIDANT ACTIVITY IN YAMALO-NENETS AUTONOMOUS DISTRICT ADULTS. Human. Sport. Medicine, 21(4), 14-21. https://doi.org/10.14529/hsm210402
Section
Physiology