EFFECT OF COLLAGEN HYDROLYSATE COMBINED WITH ELASTIN ON FUNCTIONAL JOINT STABILITY IN ATHLETES WITH CHRONIC ANKLE INSTABILITY

Keywords: collagen, collagen hydrolysate, ankle instability, CAIT, Y-balance test

Abstract

Aim. This prospective randomized placebo-controlled clinical study aims to assess the effect of parenteral administration of collagen hydrolysate combined with elastin on joint function in athletes with chronic ankle instability. Materials and methods. The study involved 40 active ranked team sport athletes. The main group included 20 athletes who received collagen hydrolysate combined with elastin (Perviy Zhivoy Collagen – first living collagen) at a dose of 10 g/day for 90 days. The placebo group also included 20 participants who took maltodextrin at a dose of 10 g/day for 90 days. Functional instability was assessed using the CAIT test, the Y-balance test, and the Visual Analogue Scale (VAS) for pain intensity. Testing was performed at baseline and at 1.5 and 3 months after the start of supplementation. Results. A 3-month administration of collagen hydrolysate resulted in a significant improvement in subjective joint stability in athletes with chronic ankle instability, as evidenced by an 18.9% increase in CAIT scores in the main group (р < 0.001) compared to a 5.6% increase in the placebo group (р = 0.021). Conclusion. These findings support existing evidence on the positive effect of prolonged administration of collagen hydrolysate with elastin on joint and ligament stability. However, further research is needed to clarify its role in pain reduction and balance improvement.

Author Biographies

B. Polyaev , N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Natural Sciences, Head of the Department of Rehabilitation, Sports Medicine, and Physical Education, Z.P. Solovyov Institute of Preventive Medicine, N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

A. Shishkin , N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Candidate of Medical Sciences, Associate Professor of the Department of Rehabilitation, Sports Medicine, and Physical Education, Senior Researcher, Research Laboratory of the Newest Technologies for Health-Improving Physical Activity, Z.P. Solovyov Institute of Preventive Medicine, N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

S. Artemyev , Perviy zhivoy collagen (First Living Collagen), Moscow, Russia

General Director, Perviy zhivoy collagen (First Living Collagen), Moscow, Russia.

I. Artemyeva , Perviy zhivoy collagen (First Living Collagen), Moscow, Russia

Creative Director, Perviy zhivoy collagen (First Living Collagen), Moscow, Russia.

N. Demin , N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Assistant Professor, Department of Rehabilitation, Sports Medicine, and Physical Education; Researcher, Research Laboratory of the Newest Technologies for Health-Improving Phy­sical Activity, Z.P. Solovyov Institute of Preventive Medicine, N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

References

References on translit

Published
2026-10-11
How to Cite
Polyaev, B., Shishkin, A., Artemyev, S., Artemyeva, I., & Demin, N. (2026). EFFECT OF COLLAGEN HYDROLYSATE COMBINED WITH ELASTIN ON FUNCTIONAL JOINT STABILITY IN ATHLETES WITH CHRONIC ANKLE INSTABILITY. Human. Sport. Medicine, 26(3), 190-197. https://doi.org/10.14529/hsm260323
Section
Rehabilitation and sports medicine