ELECTROCARDIOGRAPHIC VALUES ASSOCIATED WITH SERPAIN (PAI-1) GENE MUTATION SENSITIVITY IN YOUNG ATHLETES FOR FORECASTING CARDIOVASCULAR DISORDERS
Keywords:
SERPINE1 PAI-1 gene polymorphism, ECG (electrocardiography), young athletes, cardiovascular disorders
Abstract
Aim. The article deals with establishing the peculiarities of ECG contour analysis in athletes with various SERPINE1 (PAI-1) genotypes depending on their gender. Materials and methods. We examined 200 athletes from national teams, including 107 boys aged 14.95 ± 1.57 and 93 girls aged 15.04 ± 1.67. ECG registration was performed in standard conditions using SENSITEG 1003 equipment. SERPINE1 PAI-1 gene mutation was assessed with the help of polymerase chain reaction using REALTIME DNA-technologies. We processed the results of the study using SPSS integrated statistical system. Results. We revealed that 44.1% and 55.1% of female and male athletes, respectively, possess SERPINE1 (PAI-1) gene heterozygous form. Dominant genotype was revealed in 23.7% and 33.6% of female and male athletes, respectively, while recessive genotype was found in 32.3% and 11.2% of female and male participants, respectively. Prolonged QRS, P intervals, associated with SERPINE1 (PAI-1) recessive genotype, are more typical for male participants (7–10%). Decreased HR and alpha angle values in persons with recessive genotype are 1.7 and 2.7 times more common for female athletes. Conclusion. We revealed electrocardiographic indicators, associated with SERPINE1 (PAI-1) gene mutation in young athletes. These indicators are significant for the assessment of cardiovascular disease risks. It was established that persons with SERPINE1 (PAI-1) 4G/4G genotype can practice professional sports only under the supervision of a cardiologist.References
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2. Komolyatova V.N., Makarov L.M., Fedina N.N., Kiseleva I.I., Bessportochnyj D.A. [Ventricular Arrhythmias in Young Elite Athletes]. Pediatriya. Zhurnal im. G.N. Speranskogo [Pediatrics. Journal Them. G.N. Speransky], 2015, no. 94 (2), pp. 105–109. (in Russ.)
3. Kurnikova M.V. [Physical Development and Morbidity of Highly Skilled Athletes of Adolescence]. Uchenye zapiski SPb GMU im. I.P. Pavlova [Scientific Notes SPbGMU Them. I.P. Pavlova], 2008, no. 15 (4), pp. 65–66. (in Russ.)
4. Levickij S.N., Pervuhina O.A., Bebyakova N.A. [Role of Polymorphism of Genes of the Renin-Angiotensin System in the Formation of Cardiovascular Pathology]. Vestnik Severnogo (Arkticheskogo) federal'nogo universiteta. Ser. Mediko-biologicheskie nauki [Bulletin of the Northern (Arctic) Federal University. Ser. Biomedical Sciences], 2016, no. 4, pp. 30–39. (in Russ.) DOI: 10.17238/issn2308-3174.2016.4.30
5. Makarova G.A., Gurevich T.S., Achkasov E.E., Yur'ev S.Yu. Elektrokardiogramma sportsmena: norma, patologiya i potentsial'no opasnaya zona [Electrocardiogram of the Athlete. Norm, Pathology and Potentially Dangerous Zone]. Moscow, SPORT Publ., 2018. 256 p.
6. Pushkarev V.P., Dyatlov D.A., Lekoncev E.V., Rahmanina L.V., Pushkarev E.D., Vishnev V.Yu., Kulikov L.M. [Study of the Influence of Genetic Variations Associated with Thrombophilia on Athletic Success]. Lechebnaya fizkul'tura i sportivnaya meditsina [Therapeutic Exercise and Sports Medicine], 2011, no. 12, pp. 23–28. (in Russ.)
7. Yarysheva V.B., Shibkova D.Z. [Genetic Predictors of Adapting the Cardiovascular System of Adolescents to Physical Activity]. Kazanskij medicinskij zhurnal [Kazan Medical Journal], 2011, no. 12, pp. 23–28. (in Russ.) DOI: 10.17750/KMJ2017-63
8. Dennis M., Elder A., Semsarian C., Orchard J., Puranik R. A 10-Year Review of Sudden Death During Sporting Activities. Heart Rhythm, 2018, vol. 15, iss. 10, pp. 1477–1483. DOI: 10.1016/j.hrthm.2018.04.019
9. Bollen L., Peetermans M., Peeters M., Steen K.V., Gils A. Active PAI-1 as Marker for Venous Thromboembolism: Case-Control Study Using a Comprehensive Panel of PAI-1 and TAFI Assays. Thrombosis Research, 2014, no. 134 (5), pp. 1097–1102.
10. Maron B.J., Murphy C.J., Haas T.S., Ahluwalia A., Garberich R.F. Strategies for Assessing the Prevalence of Cardiovascular Sudden Deaths in Young Competitive Athletes. International Journal of Cardiology, 2014, vol. 173, iss. 3, pp. 369–372. DOI: 10.1016/j.ijcard.2014.02.021
11. Flannery M.D., Gerche A.L. Sudden Death and Ventricular Arrhythmias in Athletes: Screening, De-Training and the Role of Catheter Ablation. Heart, Lung and Circulation, In press, uncorrected proof, Available online 19 Oct. 2018. DOI: 10.1016/j.hlc.2018.10.004
12. Liu Y., Cheng J., Guo X., Mo J., Li Z. The Roles of PAI-1 Gene Polymorphisms in Atherosclerotic Diseases: A Systematic Review and Meta-Analysis Involving 149,908 Subjects. Gene, 2018, no. 673, pp. 167–173. DOI: 10.1016/j.gene.2018.06.040
2. Komolyatova V.N., Makarov L.M., Fedina N.N., Kiseleva I.I., Bessportochnyj D.A. [Ventricular Arrhythmias in Young Elite Athletes]. Pediatriya. Zhurnal im. G.N. Speranskogo [Pediatrics. Journal Them. G.N. Speransky], 2015, no. 94 (2), pp. 105–109. (in Russ.)
3. Kurnikova M.V. [Physical Development and Morbidity of Highly Skilled Athletes of Adolescence]. Uchenye zapiski SPb GMU im. I.P. Pavlova [Scientific Notes SPbGMU Them. I.P. Pavlova], 2008, no. 15 (4), pp. 65–66. (in Russ.)
4. Levickij S.N., Pervuhina O.A., Bebyakova N.A. [Role of Polymorphism of Genes of the Renin-Angiotensin System in the Formation of Cardiovascular Pathology]. Vestnik Severnogo (Arkticheskogo) federal'nogo universiteta. Ser. Mediko-biologicheskie nauki [Bulletin of the Northern (Arctic) Federal University. Ser. Biomedical Sciences], 2016, no. 4, pp. 30–39. (in Russ.) DOI: 10.17238/issn2308-3174.2016.4.30
5. Makarova G.A., Gurevich T.S., Achkasov E.E., Yur'ev S.Yu. Elektrokardiogramma sportsmena: norma, patologiya i potentsial'no opasnaya zona [Electrocardiogram of the Athlete. Norm, Pathology and Potentially Dangerous Zone]. Moscow, SPORT Publ., 2018. 256 p.
6. Pushkarev V.P., Dyatlov D.A., Lekoncev E.V., Rahmanina L.V., Pushkarev E.D., Vishnev V.Yu., Kulikov L.M. [Study of the Influence of Genetic Variations Associated with Thrombophilia on Athletic Success]. Lechebnaya fizkul'tura i sportivnaya meditsina [Therapeutic Exercise and Sports Medicine], 2011, no. 12, pp. 23–28. (in Russ.)
7. Yarysheva V.B., Shibkova D.Z. [Genetic Predictors of Adapting the Cardiovascular System of Adolescents to Physical Activity]. Kazanskij medicinskij zhurnal [Kazan Medical Journal], 2011, no. 12, pp. 23–28. (in Russ.) DOI: 10.17750/KMJ2017-63
8. Dennis M., Elder A., Semsarian C., Orchard J., Puranik R. A 10-Year Review of Sudden Death During Sporting Activities. Heart Rhythm, 2018, vol. 15, iss. 10, pp. 1477–1483. DOI: 10.1016/j.hrthm.2018.04.019
9. Bollen L., Peetermans M., Peeters M., Steen K.V., Gils A. Active PAI-1 as Marker for Venous Thromboembolism: Case-Control Study Using a Comprehensive Panel of PAI-1 and TAFI Assays. Thrombosis Research, 2014, no. 134 (5), pp. 1097–1102.
10. Maron B.J., Murphy C.J., Haas T.S., Ahluwalia A., Garberich R.F. Strategies for Assessing the Prevalence of Cardiovascular Sudden Deaths in Young Competitive Athletes. International Journal of Cardiology, 2014, vol. 173, iss. 3, pp. 369–372. DOI: 10.1016/j.ijcard.2014.02.021
11. Flannery M.D., Gerche A.L. Sudden Death and Ventricular Arrhythmias in Athletes: Screening, De-Training and the Role of Catheter Ablation. Heart, Lung and Circulation, In press, uncorrected proof, Available online 19 Oct. 2018. DOI: 10.1016/j.hlc.2018.10.004
12. Liu Y., Cheng J., Guo X., Mo J., Li Z. The Roles of PAI-1 Gene Polymorphisms in Atherosclerotic Diseases: A Systematic Review and Meta-Analysis Involving 149,908 Subjects. Gene, 2018, no. 673, pp. 167–173. DOI: 10.1016/j.gene.2018.06.040
References on translit
1. Degtyaryova E.A., Kantemirova M.G., Zhdanova O.I., Trosheva O.N. [Myocarditis in Young Athletes]. Kazanskij meditsinskij zhurnal [Kazan Medical Journal], 2015, no. 96 (4), pp. 669–674. (in Russ.)2. Komolyatova V.N., Makarov L.M., Fedina N.N., Kiseleva I.I., Bessportochnyj D.A. [Ventricular Arrhythmias in Young Elite Athletes]. Pediatriya. Zhurnal im. G.N. Speranskogo [Pediatrics. Journal Them. G.N. Speransky], 2015, no. 94 (2), pp. 105–109. (in Russ.)
3. Kurnikova M.V. [Physical Development and Morbidity of Highly Skilled Athletes of Adolescence]. Uchenye zapiski SPb GMU im. I.P. Pavlova [Scientific Notes SPbGMU Them. I.P. Pavlova], 2008, no. 15 (4), pp. 65–66. (in Russ.)
4. Levickij S.N., Pervuhina O.A., Bebyakova N.A. [Role of Polymorphism of Genes of the Renin-Angiotensin System in the Formation of Cardiovascular Pathology]. Vestnik Severnogo (Arkticheskogo) federal'nogo universiteta. Ser. Mediko-biologicheskie nauki [Bulletin of the Northern (Arctic) Federal University. Ser. Biomedical Sciences], 2016, no. 4, pp. 30–39. (in Russ.) DOI: 10.17238/issn2308-3174.2016.4.30
5. Makarova G.A., Gurevich T.S., Achkasov E.E., Yur'ev S.Yu. Elektrokardiogramma sportsmena: norma, patologiya i potentsial'no opasnaya zona [Electrocardiogram of the Athlete. Norm, Pathology and Potentially Dangerous Zone]. Moscow, SPORT Publ., 2018. 256 p.
6. Pushkarev V.P., Dyatlov D.A., Lekoncev E.V., Rahmanina L.V., Pushkarev E.D., Vishnev V.Yu., Kulikov L.M. [Study of the Influence of Genetic Variations Associated with Thrombophilia on Athletic Success]. Lechebnaya fizkul'tura i sportivnaya meditsina [Therapeutic Exercise and Sports Medicine], 2011, no. 12, pp. 23–28. (in Russ.)
7. Yarysheva V.B., Shibkova D.Z. [Genetic Predictors of Adapting the Cardiovascular System of Adolescents to Physical Activity]. Kazanskij medicinskij zhurnal [Kazan Medical Journal], 2011, no. 12, pp. 23–28. (in Russ.) DOI: 10.17750/KMJ2017-63
8. Dennis M., Elder A., Semsarian C., Orchard J., Puranik R. A 10-Year Review of Sudden Death During Sporting Activities. Heart Rhythm, 2018, vol. 15, iss. 10, pp. 1477–1483. DOI: 10.1016/j.hrthm.2018.04.019
9. Bollen L., Peetermans M., Peeters M., Steen K.V., Gils A. Active PAI-1 as Marker for Venous Thromboembolism: Case-Control Study Using a Comprehensive Panel of PAI-1 and TAFI Assays. Thrombosis Research, 2014, no. 134 (5), pp. 1097–1102.
10. Maron B.J., Murphy C.J., Haas T.S., Ahluwalia A., Garberich R.F. Strategies for Assessing the Prevalence of Cardiovascular Sudden Deaths in Young Competitive Athletes. International Journal of Cardiology, 2014, vol. 173, iss. 3, pp. 369–372. DOI: 10.1016/j.ijcard.2014.02.021
11. Flannery M.D., Gerche A.L. Sudden Death and Ventricular Arrhythmias in Athletes: Screening, De-Training and the Role of Catheter Ablation. Heart, Lung and Circulation, In press, uncorrected proof, Available online 19 Oct. 2018. DOI: 10.1016/j.hlc.2018.10.004
12. Liu Y., Cheng J., Guo X., Mo J., Li Z. The Roles of PAI-1 Gene Polymorphisms in Atherosclerotic Diseases: A Systematic Review and Meta-Analysis Involving 149,908 Subjects. Gene, 2018, no. 673, pp. 167–173. DOI: 10.1016/j.gene.2018.06.040
Published
2018-11-01
How to Cite
Shibkova, D., Yarysheva, V., Baiguzhin, P., & Romanov, Y. (2018). ELECTROCARDIOGRAPHIC VALUES ASSOCIATED WITH SERPAIN (PAI-1) GENE MUTATION SENSITIVITY IN YOUNG ATHLETES FOR FORECASTING CARDIOVASCULAR DISORDERS. Human. Sport. Medicine, 18(S), 7-12. https://doi.org/10.14529/hsm18s01
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Section
Physiology
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