BLOOD AMINO ACID POOL AND SECRETORY FUNCTION OF THE STOMACH AT REST AND UNDER EXERCISE

Abstract

Aim: to study the effect of physical activity on the enzyme function of the stomach and the role of free blood amino acids in inhibiting secretory function of the stomach. Materials and methods. The secretory function of the stomach and the blood content of 15 free amino acids were investigated by fractional gastric intubation in 16 highly skilled male road bicycle racers (candidates for master of sports, master of sports, sports experience of 6.12 ± 0.8 years) ages 18–23. Pentagastrin (6 mcg per kg body weight subcutaneously) was used as a stimulant of gastric secretion. Bicycle ergometer load per hour was equal to 73.800 kgm. Results. Bicycle ergometer load reduces the content of enzymes that break down proteins (pepsinogen P < 0.01, total proteolytic activity P < 0.05, lipase P < 0.001) and causes an increase in the total pool of free amino acids to 125 ± 11.4 % (P < 0.05). A negative correlation r = –0.69 (P < 0.01) was found between pepsinogen content in gastric secretion stimulated by pentagastrin and glutamic acid, as well as between pepsinogen and aspartic acid r = –0.64 (P < 0.01). Conclusion. The inhibitory effect on gastric secretion and especially the enzyme function of the stomach under exercise is provided by an increase in aspartic and glutamic acids along with the nervous endocrine mechanisms.