STOMACH SECRETORY FUNCTION UNDER MUSCLE LOAD IN THE CONDITIONS OF PHARMACOLOGICAL BLOCADE OF M-CHOLINORECEPTORS AND β-ADRENOCEPTORS

Abstract

Aim. The article deals with establishing the effect of muscle load on the stomach secretory function in the conditions of partial pharmacological blockade of M-cholinoreceptors and β-adrenoceptors in patients with duodenal acidification. Materials and methods. 22 males aged 18–23 years participated in the study. The stomach secretory function at rest under a 30-minute cycle ergometer load of 36 900 kgm combined with a partial pharmacological blockade of M-cholinoreceptors (1.5 mg per kg of body mass) and β-adrenoceptors (0.6 mg obsidan per kg of body mass) was studied using gastric and gastroduodenal intubation. Results. The blockade of M-cholinoreceptors at muscle rest provoked a noticeable decrease in the total content of electrolytes (p < 0.01), enzymes (p < 0.001), HCL (p < 0.001), and proteolytic activity (p < 0.001) in gastric juice. The combined activity of atropine and physical load in the conditions of duodenal acidification inhibited the amount of secretion significantly to 49.9 ± 11.1%, HCl to 29.7 ± 9.4%, pepsinogen to 19.8 ± 7.4% (p ˂ 0.001). The blockade of β-adrenoceptors significantly decreased the stomach secretory function in the conditions of basal secretion and duodenal acidification. After using a 10% dried cabbage decoction as a stimulator we registered an increase in the amount of secretion up to 141.1 ± 12.2%, HCl discharge – to 186.3 ± 21.9%, and pepsinogen – to 188.5 ± 20.4%. The same tendency was registered for the cycle ergometer test in the conditions of the blockade of β-adrenoceptors. Conclusion. The effect of muscle load on the stomach secretory function contributes significantly to the role of the sympathetic nervous system. Duodenal acidification in the conditions of the blockade of β-adrenoceptors intensifies the inhibitory effect, while stimulation with a dry cabbage decoction improves the stomach secretory function.